ID A0A2P8VMN6_9ENTR Unreviewed; 410 AA.
AC A0A2P8VMN6;
DT 23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT 23-MAY-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Multifunctional transcriptional regulator/nicotinamide-nucleotide adenylyltransferase/ribosylnicotinamide kinase NadR {ECO:0000313|EMBL:PSN08819.1};
DE EC=2.7.7.1 {ECO:0000313|EMBL:PSN08819.1};
GN ORFNames=C7G83_05545 {ECO:0000313|EMBL:PSN08819.1};
OS Siccibacter turicensis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Siccibacter.
OX NCBI_TaxID=357233 {ECO:0000313|EMBL:PSN08819.1, ECO:0000313|Proteomes:UP000240212};
RN [1] {ECO:0000313|EMBL:PSN08819.1, ECO:0000313|Proteomes:UP000240212}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=6100069499-17 {ECO:0000313|EMBL:PSN08819.1,
RC ECO:0000313|Proteomes:UP000240212};
RA Lepuschitz S., Pekard-Amenitsch S., Haunold R., Schill S., Mach R.,
RA Allerberger F., Ruppitsch W., Forsythe S.J.;
RT "Draft genome sequence of the first documented clinical Siccibacter
RT turicensis isolate in Austria.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PSN08819.1}.
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DR EMBL; PYEP01000002; PSN08819.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2P8VMN6; -.
DR STRING; 1388748.GCA_000463155_03268; -.
DR OrthoDB; 3249147at2; -.
DR Proteomes; UP000240212; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0000309; F:nicotinamide-nucleotide adenylyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0050262; F:ribosylnicotinamide kinase activity; IEA:InterPro.
DR GO; GO:0009435; P:NAD biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00093; HTH_XRE; 1.
DR CDD; cd02167; NMNAT_NadR; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR001387; Cro/C1-type_HTH.
DR InterPro; IPR004821; Cyt_trans-like.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR InterPro; IPR016429; NAD_NadR.
DR InterPro; IPR038727; NadR/Ttd14_AAA_dom.
DR InterPro; IPR006417; NadR_NMN_Atrans.
DR InterPro; IPR041749; NMNAT_NadR.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR NCBIfam; TIGR00125; cyt_tran_rel; 1.
DR NCBIfam; TIGR01526; nadR_NMN_Atrans; 1.
DR PANTHER; PTHR37512:SF1; AAA_28 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR37512; TRIFUNCTIONAL NAD BIOSYNTHESIS/REGULATOR PROTEIN NADR; 1.
DR Pfam; PF13521; AAA_28; 1.
DR Pfam; PF01467; CTP_transf_like; 1.
DR Pfam; PF01381; HTH_3; 1.
DR PIRSF; PIRSF004776; NadR_NMNAT/RNK; 1.
DR SMART; SM00530; HTH_XRE; 1.
DR SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50943; HTH_CROC1; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:PSN08819.1};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR004776-1};
KW Nucleotidyltransferase {ECO:0000313|EMBL:PSN08819.1};
KW Transferase {ECO:0000313|EMBL:PSN08819.1}.
FT DOMAIN 7..62
FT /note="HTH cro/C1-type"
FT /evidence="ECO:0000259|PROSITE:PS50943"
FT BINDING 70..73
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR004776-1"
FT BINDING 77
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR004776-1"
FT BINDING 104
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR004776-1"
FT BINDING 144..157
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR004776-1"
FT BINDING 177..179
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR004776-1"
FT BINDING 204..206
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR004776-1"
FT BINDING 259..261
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR004776-1"
SQ SEQUENCE 410 AA; 47082 MW; E4446D8BB44184DE CRC64;
MSSFDYLKTA IRQQGCTLQQ VAAACGMTKG YLSQLLNAKI KSPSAQKLEA LHRFLGLEFP
RKQKNIGVVF GKFYPLHTGH IYLIQRACSQ VDELHIIMGY DDKRDRALFD ASAMSQQPTV
PDRLRWLLQT FKYQKNIRIH AFNEEGMEPY PHGWDVWSHG IKGFMEEKGI APDWIYTSEE
ADAAQYLEHL GIETVLIDPK RTFMNISGSQ IRENPFRYWE YIPTEVKPFF VRTVAVLGGE
SSGKSTLVNK LANIFNTTSA WEYGRDYVFS HLGGDEMALQ YSDYDKIALG HAQYIDFAVK
YANKVAFVDT DFVTTQAFCK KYEGREHPFV QALIDEYRFD LVILLENNTP WVADGLRSLG
SSVDRTEFQS MLIDMLDANH IDYVHVKESD YDTRFLRCVD LVKKLMGEQG
//
