ID A0A2P8VP59_9ENTR Unreviewed; 1117 AA.
AC A0A2P8VP59;
DT 23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT 23-MAY-2018, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Mechanosensitive channel MscK {ECO:0000313|EMBL:PSN09343.1};
GN ORFNames=C7G83_00885 {ECO:0000313|EMBL:PSN09343.1};
OS Siccibacter turicensis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Siccibacter.
OX NCBI_TaxID=357233 {ECO:0000313|EMBL:PSN09343.1, ECO:0000313|Proteomes:UP000240212};
RN [1] {ECO:0000313|EMBL:PSN09343.1, ECO:0000313|Proteomes:UP000240212}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=6100069499-17 {ECO:0000313|EMBL:PSN09343.1,
RC ECO:0000313|Proteomes:UP000240212};
RA Lepuschitz S., Pekard-Amenitsch S., Haunold R., Schill S., Mach R.,
RA Allerberger F., Ruppitsch W., Forsythe S.J.;
RT "Draft genome sequence of the first documented clinical Siccibacter
RT turicensis isolate in Austria.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the MscS (TC 1.A.23) family.
CC {ECO:0000256|ARBA:ARBA00008017}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PSN09343.1}.
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DR EMBL; PYEP01000001; PSN09343.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2P8VP59; -.
DR STRING; 1388748.GCA_000463155_01747; -.
DR OrthoDB; 9799209at2; -.
DR Proteomes; UP000240212; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 1.10.287.1260; -; 1.
DR Gene3D; 2.30.30.60; -; 1.
DR Gene3D; 3.30.70.100; -; 1.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR049142; MS_channel_1st.
DR InterPro; IPR049278; MS_channel_C.
DR InterPro; IPR023408; MscS_beta-dom_sf.
DR InterPro; IPR006685; MscS_channel_2nd.
DR InterPro; IPR011066; MscS_channel_C_sf.
DR InterPro; IPR006686; MscS_channel_CS.
DR InterPro; IPR011014; MscS_channel_TM-2.
DR InterPro; IPR025692; MscS_IM_dom1.
DR InterPro; IPR024393; MscS_porin.
DR PANTHER; PTHR30347:SF8; MECHANOSENSITIVE CHANNEL MSCK; 1.
DR PANTHER; PTHR30347; POTASSIUM CHANNEL RELATED; 1.
DR Pfam; PF21088; MS_channel_1st; 1.
DR Pfam; PF00924; MS_channel_2nd; 1.
DR Pfam; PF21082; MS_channel_3rd; 1.
DR Pfam; PF12795; MscS_porin; 1.
DR Pfam; PF12794; MscS_TM; 1.
DR SUPFAM; SSF82689; Mechanosensitive channel protein MscS (YggB), C-terminal domain; 1.
DR SUPFAM; SSF82861; Mechanosensitive channel protein MscS (YggB), transmembrane region; 1.
DR SUPFAM; SSF50182; Sm-like ribonucleoproteins; 1.
DR PROSITE; PS01246; UPF0003; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 32..1117
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015175666"
FT TRANSMEM 495..516
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 548..574
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 580..602
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 622..642
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 654..675
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 687..712
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 724..743
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 792..816
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 836..856
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 877..898
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 910..938
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 46..285
FT /note="Mechanosensitive ion channel MscS porin"
FT /evidence="ECO:0000259|Pfam:PF12795"
FT DOMAIN 504..822
FT /note="Mechanosensitive ion channel inner membrane"
FT /evidence="ECO:0000259|Pfam:PF12794"
FT DOMAIN 883..924
FT /note="Mechanosensitive ion channel transmembrane helices
FT 2/3"
FT /evidence="ECO:0000259|Pfam:PF21088"
FT DOMAIN 926..991
FT /note="Mechanosensitive ion channel MscS"
FT /evidence="ECO:0000259|Pfam:PF00924"
FT DOMAIN 999..1082
FT /note="Mechanosensitive ion channel MscS C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21082"
FT REGION 1095..1117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 126..160
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1095..1111
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1117 AA; 126307 MW; A490524F2AA0630B CRC64;
MQHFTYIRHS AMAFVIAFLI AIFGAPHNAT AAQPGDVPSR TEIQNQLDAL NKQKSLSGEE
KLTQQDLTET LETLDKIDRV KQETEQLRQR IAQAPAKMAR ATADLNELSN QESDEALAKS
FNAMRLHDLE QRLATVLDKL QTSQNDLATL NSQLVSLQTQ PERVQNTMFA VSQQLQTIRS
RLNGTGPGEQ ALRPSQQTLL TAQQALLNAQ LEQQRKSLEG NTVLQDSLQK QRDYMTANIN
QLEHQVQLLQ TAVSNKRLTL TERTAQEATS PDDASRIQNN PLVRQELDIN HQLSERLITA
TQMGNGLVER NIKVKNWLDR ALQSERSLKE QIAVLKGSLL LSRILYQQQQ TLPSADELED
MTNRIADLRL EQFEINQQRD ALFQGDSWVD KLEEGHQNEV NPEVHDALLD IIDMRRALLD
QLNKQLGNQL MMAINLQINQ QQLVSVSKSL EQILTQQIFW VNSNKPMDWE WIKSFPGALH
DQIKAMKLTV NWDKAWPGVA LALLAGLPLV LLAGLIRWRF GWIRQYLARL ASEVGQLRND
SQLHTPKAIL LNLILALPVC LIILAVGLIL HVMQLSISEL LWAFSKKLAV FWLVFGLCWR
VLEKDGVAVN HFNMPAQLTS HWRRQIVRVS LALLPLLFWS VVAELSPLHL MDDVLGQSMI
FLNLLVIAAL VWPMCRESWH DKESHTMRLV TITILSIVPV ALLVLTASGY FYTTLRLSGR
WIDTVYLVII WNLLYQTVLR GLSVAARRIA YRRAVSRRQN QVKEGAEGAE PVQEPPLALD
QINQQTLRLT TLLMFALFGL MFWAIWSDLI TVFSYLDSVV LWHYNGNEAG AAVVKNVTMG
SLLFALVAFT VAWALIRNLP GLLEVLVLSR LKMRQGASYA ITTILNYVII AAGAMTVFAS
LGVSWDKLQW LAAALSVGLG FGLQEIFGNF VSGLIILFER PVRIGDTVTI GTFSGTVSKI
RIRATTITDF DRKEVIIPNK AFVTERLINW SLSDTITRVV IRIGVAYGSD LDKVKKILLK
AAMEHPKVMH DPEPSVFFTT FGPSTLDHEL RLYVRELRDR SYTVDELNRT IDRLCRENDI
NIAFNQLEVH LRNEKGEEHT EVKRDINKDE GDAPANA
//
