ID A0A2R2MIK7_LINUN Unreviewed; 2093 AA.
AC A0A2R2MIK7;
DT 23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT 23-MAY-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Myotubularin-related protein 13 isoform X1 {ECO:0000313|RefSeq:XP_023930024.1};
GN Name=LOC106168468 {ECO:0000313|RefSeq:XP_023930024.1};
OS Lingula unguis.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_023930024.1};
RN [1] {ECO:0000313|RefSeq:XP_023930024.1}
RP IDENTIFICATION.
RC TISSUE=Gonads {ECO:0000313|RefSeq:XP_023930024.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
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DR RefSeq; XP_013402966.1; XM_013547512.1.
DR RefSeq; XP_023930024.1; XM_024074256.1.
DR STRING; 7574.A0A2R2MIK7; -.
DR EnsemblMetazoa; XM_024074256.1; XP_023930024.1; LOC106168468.
DR KEGG; lak:106168468; -.
DR InParanoid; A0A2R2MIK7; -.
DR OrthoDB; 3195274at2759; -.
DR Proteomes; UP000085678; Unplaced.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd20827; C1_Sbf-like; 1.
DR CDD; cd13208; PH-GRAM_MTMR5_MTMR13; 1.
DR CDD; cd01235; PH_Sbf1_hMTMR5; 1.
DR CDD; cd14534; PTP-MTMR5-like; 1.
DR Gene3D; 3.30.450.200; -; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR004182; GRAM.
DR InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR InterPro; IPR030564; Myotubularin_fam.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR022096; SBF1/SBF2.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR PANTHER; PTHR10807:SF109; SET DOMAIN BINDING FACTOR, ISOFORM A; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF02893; GRAM; 1.
DR Pfam; PF06602; Myotub-related; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF12335; SBF2; 1.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00568; GRAM; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00800; uDENN; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50211; DENN; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 6..425
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT DOMAIN 1172..1756
FT /note="Myotubularin phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51339"
FT DOMAIN 1890..1942
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 1989..2093
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 692..728
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1101..1151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 698..720
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1107..1140
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2093 AA; 235593 MW; 7318AC57635A9BC4 CRC64;
MSRLADYFVV VGYDQEKERS GTSQGKIIQR FPEKDWPGSP FTLGIELFCQ PTGWSLSTQR
HPPTFFVSVL TDIDADRHYC ACLTFHETVS MTSTKPDDED GDDGTPIRQS LMYAPKCLVL
VSKFPEFETF RNCLGLIYTV YLENMQFQIE TLVGNILGCV QVPPPGGPQI RFSIGAGDRQ
ALQPPVSSTI PTSGTSVAML FRQMGITNTI MLFCAAATDL KVLFHSQSYT RLTAASQALM
ALMYPLKYSY VYIPLLPSHL LEVLNTPTPF IAGVHSSLKD EVSDLLDVII ADLDGGSVHV
PECVTVPVLP NIVLSRTTEA LTMILNPELF TSDYAFPPNP AKLSSLTMQD KEIRAVFLRL
FAELFTGYRS CLTLIRIHPE PFITFHKASF LGHRAMVSED FLTRVLDGMS YSTFVSERGP
PFRVIDIFDE VYATLSDMIK HENGSQEKMM QSIKDLAQQL YINEHPNPQP YTQKIPKPPE
GAYSRIHQPQ FPILDWIMVQ EIIDDGLAKS GIKSKLSQIR PPQPRIVPMG PHITTVAEKM
QMLNNNARRL EVLRNCVSCI FENKISDARK VFPAVLRALK SKVSRLALCQ ELAYHVQSNR
AMLEHQQFDL VVRLLNCALQ NESSMDENGV AAAMLPLVTS FCRKLCTGVI QFAYTCVQEH
AVWANHQFWE ATFYQDVQRQ IRQLYAPQYE QEHSADKLSP PASPTTEGAE LSSSWGATGS
WKGSPMDPRR RSITNMKYLK PKEVNALEIA AEQMAKCYDP QLRKWPNLSE SEKEEMINNE
ESTVYSQAIH YANRMVYMRV PLDVTRGANL HFGADWESAS NSNITNSHVQ RKDHFYSSSI
AESDSVDAES GFDEQEISEV GANVVKFVSR FVDKVCTESG VTADHIRSLH QMIPGVVAMH
IETLEAVARE SKRLPPIQKP KILTPTLLPG EEIVMEGLRV YLLPDGREEA TGGSTGGPAL
IPAEGAIFLT TYRIIFKGTP CDPLACEQIV VRYFPVSTLT KEKKLSSQYL SYVDQYLQEI
IQMRANTFQL MKVGFDEEVS SEDVETFRKL TSKIRSPISV FSTFAFSGYQ FAQPAQLIKH
KEKHASLKGF AKKTLMKTAR KAGLAKPKSA STSQRKQKYI LPTPPPSRRS TASLDSMDSD
SRPASGVFDD ESLMDENEPV MSWTPDPKNL ERLGERAGYK DYQRLGLGSL NFNSAKSKTE
PFRITTVNAT YSVCRSYPAM LVVPQTVSDD SIRKFARSHR QYRFPVVSWY HPKTKALLLR
ASGFHSKGMM GMFKSHHNAP SGTSGEITST SVEQEKYFHA IVQCTPMGNL QHQQQSHNKS
LSDSLTSIDS LMLSTDTLAL PDTPSLSRKN PIARAVNSLR SSGGKVKLTD NCMANNSRES
ALAAGVAYSI STPTMSRRSP LLRRTIHGSL RANAGKGGKS LGRLGSVRDR RAVTSSGSLE
VGMRLAMKSN GSIDHSAELE SQTQGLNKAA LYVLGEKAQV KNIKVDSFPK CEFVPVDFYE
VRQVKTSFKK LLRACVPSAL LTDAEHSFYK LVQESEWLQQ LQSLMQLSGA VVDLIDLQGS
SVMVCLEDGW DITTQVVSLA QVCLDPYYRT IKGFQALVEK EWLSFGHRFT HRSNQTAANQ
ASGFAPVFLQ FLDAVHQVHR QFPLSFEYND FFLKFLAYHT VSNRFRTFML DNESERMEAG
WLLEEKPKTS KIDGAATGED GFTLRQTMGT SVWDYIDKHH RRSPVFYNFS YVSMDGTNVL
RPYSGIASLE LWDYYLTEDL SHGPPYDFET MYMDKKQNEE IEAIDGPLAP SSRRIVNGCY
DTIWHLEPEC FSLAFQDIHK TQTKLDHLPM KWKAVWEKLD HPQSETLQRQ MSLKTRLTRS
HGRTLHKRST LEILVRGKMA GDAIKSFGQP HRFEKFDFTT ASYCDHCGHL LWGLTQVKQG
MRCADCGYNC HEKCVSSVPK NCAKLIRTPS EQPDSSVNLA EAQPHAPGDV TIQASRDMYR
QFSARAQEHR THEGYLLKQG ALLKQWKQRW FVLDSMKHQL RWYDAMEDSH CKGYLDLSEV
TSVGTSKNFQ GAPKRAEDNS FFEMKTVKRS YVFCAPNVQA SQEWIDKLNS CIQ
//
