UniProt: A0A2R2MIP0

Database: UniProt
Entry: A0A2R2MIP0_LINUN

LinkDB:  A0A2R2MIP0_LINUN 
Original site:  A0A2R2MIP0_LINUN

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Ontology (5)   
   GO (5)   
Protein sequence (1)   
   RefSeq(pep) (1)   
Protein domain (20)   
   InterPro (9)   
   Pfam (4)   
   PROSITE (3)   
   SMART (4)   
All databases (26)   

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ID   A0A2R2MIP0_LINUN        Unreviewed;      2455 AA.
AC   A0A2R2MIP0;
DT   23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT   23-MAY-2018, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Spectrin alpha chain-like isoform X4 {ECO:0000313|RefSeq:XP_023929927.1};
GN   Name=LOC106175284 {ECO:0000313|RefSeq:XP_023929927.1};
OS   Lingula unguis.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC   Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX   NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_023929927.1};
RN   [1] {ECO:0000313|RefSeq:XP_023929927.1}
RP   IDENTIFICATION.
RC   TISSUE=Gonads {ECO:0000313|RefSeq:XP_023929927.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000256|ARBA:ARBA00004245}.
CC   -!- SIMILARITY: Belongs to the spectrin family.
CC       {ECO:0000256|ARBA:ARBA00006826}.
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DR   RefSeq; XP_023929927.1; XM_024074159.1.
DR   EnsemblMetazoa; XM_024074159.1; XP_023929927.1; LOC106175284.
DR   Proteomes; UP000085678; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR   GO; GO:0051693; P:actin filament capping; IEA:UniProtKB-KW.
DR   CDD; cd00051; EFh; 1.
DR   CDD; cd11808; SH3_Alpha_Spectrin; 1.
DR   CDD; cd00176; SPEC; 12.
DR   Gene3D; 1.20.58.60; -; 19.
DR   Gene3D; 1.10.238.10; EF-hand; 2.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR035825; Alpha_Spectrin_SH3.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR014837; EF-hand_Ca_insen.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   InterPro; IPR018159; Spectrin/alpha-actinin.
DR   InterPro; IPR002017; Spectrin_repeat.
DR   PANTHER; PTHR11915:SF422; PH_9 DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR   PANTHER; PTHR11915; SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN; 1.
DR   Pfam; PF13499; EF-hand_7; 1.
DR   Pfam; PF08726; EFhand_Ca_insen; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   Pfam; PF00435; Spectrin; 20.
DR   PRINTS; PR00452; SH3DOMAIN.
DR   PRINTS; PR01887; SPECTRNALPHA.
DR   SMART; SM00054; EFh; 2.
DR   SMART; SM01184; efhand_Ca_insen; 1.
DR   SMART; SM00326; SH3; 1.
DR   SMART; SM00150; SPEC; 20.
DR   SUPFAM; SSF47473; EF-hand; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   SUPFAM; SSF46966; Spectrin repeat; 16.
DR   PROSITE; PS00018; EF_HAND_1; 2.
DR   PROSITE; PS50222; EF_HAND_2; 2.
DR   PROSITE; PS50002; SH3; 1.
PE   3: Inferred from homology;
KW   Actin capping {ECO:0000256|ARBA:ARBA00022467};
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          977..1036
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          2306..2341
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
FT   DOMAIN          2349..2384
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
FT   COILED          295..354
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          612..675
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          935..969
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1118..1185
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1225..1252
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1718..1746
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1821..1852
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   2455 AA;  283950 MW;  EAA8E0895EB4AF76 CRC64;
     MTSAEVHPRE IKILETAEDI QERRAEVLGR YAAFKDATHQ RRLMLEDARN FQYFRRDADE
     LESWILEKLQ TASDESWKDT TNLQAKIQKH QAFEAEVQAH SNAIVELDNR GMEMINADHF
     ASDIIKARLE EIHRLWELLL SKLQDKGIKL QQALVLVQFF RECSEVMFWI TDKEAFVTSE
     EFGHDLEHVE VLQKKYDEFR KDLESHEYRV TEVNGMAEKL LSDGHPSEEQ IREKQIELNE
     AWQRLKQLAI LRQEKLSGAH EIQQFNRDAD ETIAWITEKD GLLSTDDYGR DLASVQGLQR
     KHEGAERDLA ALEERVTQLN AESGRLSAEY PDHADEVQTK QDEINQNWAR LQEKAEERKN
     RLDDSYHLQR FLADFRDLVS WIHEMMAIIS ADDLAKDVAG AESLLERHQE HKGEIDARED
     SFKTTADAGK QLLESDHYAT EEVKEKLVQL ANEKTTLLEL WEERRILYEQ CMDLQLFYRD
     TEQADAWMSK QEAFLQNEDL GDSLDSVEAL IKKHEDFEKS LAAQEEKIHA LDEFATKLIE
     NEHYAADDVA ARRDALLQRR NALYERSGAR RRMLEDSLRF QVFERDCDET KSWINEKLKT
     ASDESYLDPT NLQNKVQKHQ NFEQELAANQ SRIEAVNKQG QDLIDSNHFA SDITRERLEE
     IQELWQQLNE QTEKKSGRLN EASEQQAYNR NVEDVELWLT EIENFLMSED FGKIITKGDL
     TSVQNLQKKH ALLEADVAAH QDRVDSISQQ ADEFVDNGHF DADNIVAKKD AMVERYNALQ
     EPMNARKQKL IDALQLQQFI RDIEDEEDWI REKEPIAAST NRGRDLIGVQ NLMKKHQALL
     AELGGHEPRI GCVCEQGQEM INENHFASDE IQQRIAGLQE KWNNLKEKAF QRKQDLEDSL
     EAQQYFADAN EAESWMKEKV PIVSSTDYGK DEDSAEALLK KHEALMADLE AYKTNIDNLQ
     YQAKACRQQE APVIDDFGKE CVVALYDYTE KSPREVSMKK GDVLTLLNSS NKDWWKVEVN
     DRQGFVPAAY VKKVDQPLTA SQDNLARDFT VSIRQRQIED QYEALIDLAQ QRRDKLSESC
     QAYKLVREAG ELGQWMIEKE NAVVEEAIIP EQADLEQVEV QQKKFDDFQK DLKAHEERLV
     ELNQIADNLT RMGQTEAAAK IRIQIEELNR RWERLQNTAQ DKAKTLASSH EVQRYHRDVD
     ETKEWIDEKD QALNTDDYGS DLASVQRLQR KHEGVERDLA ALGEKVQQLD ETAGRLVETH
     PDVSDSVKAH QAEINEMWNS LTEKANARKA KLLDSYDYQR FLSDYRDLTS WINSMQALVS
     SDELAKDVTG AEALLERHQN LHTDIASRYV PYQVLENAEE EAEDEEHRTE IDARAGTFQA
     FEVFGYQLLQ AHHFASDDVQ DKLNELAKAR EKLEKAWIAR RMKLDQCLEL QLFLRDCEQA
     ENWMAAREAF LGGDSTDGAP DSVESLIKKH EDFDRAVSAQ EEKIASLEQF SEQLVNADHY
     DKDSIEEKKA EVLDRWANLK SALIENRSKL GEAQTLQQFC RDADEMEVWI TEKVALASDE
     SYKDPANVQA KHQKHQAFEA ELAANTDRLQ ATIAAGQNLI DEGKCQGQEE AVRKRIANLA
     EQWEYLVVKT TEKSVKLKEA SKQQQFNAAV KDIEFWLGEV EQLLQSQEYG KDLASVQNLL
     KKHQLLDADI TAHDDRIKDM NNQADQFIEG GGWDPESIRE KKNSINERYE KIKELSKDRR
     TKLEEANTLH QFFRDIDDEE AWIKEKKLLV GSDDYGRDLT GVQNLRKKHK RLEAELASHE
     PAIQAVQETA EKLMTETQIG SEEIANRLQQ LNENWEELKQ MASNRGQKLE ESLAYQQFSA
     NIEEEEAWIN EKQHLLSGED YGDTLAAVQG LLKKHDAFET DLRVHQDRCT EIKTNGDKLI
     DEGNHNADHI ASRCQALMNK MEDLGESAKH RKAKLIDNSA FLQFIWKTDV VESWIADKET
     QVKSEDYGRD LSSVQTLLTK QETFDAGLQA FEKEGIQTIT ALKDQLVAAN HAQTPAIQKR
     YDYVIQRWQK LLADSEARKQ RLLRLQEQYR QVEDLYLTFA KKASAFNSWF ENAEEDLTDP
     VRCNSVEEIK ALREAHDQFK ASLSAAQADF NQLAALDKQI KSFNVGPNPY TWFTMENLDD
     TWRNLQKIIK ERDAELAREQ QRQEENDVLR KQFAQAANAF HSWLTETRMW LLDPQAMMEG
     TGTLEDQLEA TKKKSAEVRA QKGQLKRIED LGAALEERLI LDNRYTEHST VGLAQQWDQL
     DQLGMRMQHN LEQQIQARNQ SGVSEDALRE FSMMFKHFDK DKSGKLDHHE FKSCLRALGY
     DLPMVEEGQV DPEFVAILDS VDPNRDGYVS LQEYMAFMIS RETENVQSSK DVEEAFRALT
     SGDKPYITAS ELYQNLTKEQ ADYCISRMKK YQDPKGREIM EAYDYAEFTQ SLFVN
//

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