ID A0A2R2MKD1_LINUN Unreviewed; 3606 AA.
AC A0A2R2MKD1;
DT 23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT 23-MAY-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=WD repeat and FYVE domain-containing protein 3 {ECO:0000313|RefSeq:XP_023930684.1};
GN Name=LOC106164305 {ECO:0000313|RefSeq:XP_023930684.1};
OS Lingula unguis.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_023930684.1};
RN [1] {ECO:0000313|RefSeq:XP_023930684.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26383154;
RA Luo Y.J., Takeuchi T., Koyanagi R., Yamada L., Kanda M., Khalturina M.,
RA Fujie M., Yamasaki S.I., Endo K., Satoh N.;
RT "The Lingula genome provides insights into brachiopod evolution and the
RT origin of phosphate biomineralization.";
RL Nat. Commun. 6:8301-8301(2015).
RN [2] {ECO:0000313|RefSeq:XP_023930684.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_023930684.1; XM_024074916.1.
DR STRING; 7574.A0A2R2MKD1; -.
DR EnsemblMetazoa; XM_024074916.1; XP_023930684.1; LOC106164305.
DR KEGG; lak:106164305; -.
DR InParanoid; A0A2R2MKD1; -.
DR OrthoDB; 47483at2759; -.
DR Proteomes; UP000085678; Unplaced.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd06071; Beach; 1.
DR CDD; cd15719; FYVE_WDFY3; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR031570; NBEA/BDCP_DUF4704.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46108; BLUE CHEESE; 1.
DR PANTHER; PTHR46108:SF4; BLUE CHEESE; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF15787; DUF4704; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 2504..2628
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 2656..2949
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 3093..3134
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 3534..3594
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REGION 792..826
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 950..982
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1885..1904
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2430..2474
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3238..3287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3302..3371
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 810..826
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 955..969
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2441..2465
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3238..3252
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3253..3270
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3340..3355
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3606 AA; 401856 MW; B9C10378F4CC6A7D CRC64;
MNLMRKLVGQ SARPGMEVSQ SNSDNSLGLT HLRKLFAEFR HPSTSYTSKD QEEKLYNMLP
LFCKVFGGSP SNDMTEKFGD ILQFCSHVSK LMVTEIRRRA SNQSTEAASC AIVKFLEIDT
TEESSNGWML LSTLNLLSTG AHSLIDCMTA ASLPSTLVKC LYLFFDLPGA KIEDRSHSEF
TSEERRILLQ KVFVQVLVRL CSHTAPAEEL ARKDDLTLLF SAITSWCPAH NVPWRKSAAE
VLMTLSRHGL TPNVVQYIHS KGCVALCIEN MKRNQDLTPL EIVEMFVTVF CFLKDSSEVS
QILLDDFRSC QGYIFLSDFL LRLEQDEDEE TRQALRNLVL LMGSLTTCGY IELKPTQAST
GSLYQMPGFT LPQPAGKGVS VRNIQAFQVL QSVFQRASSS HLCSIILDVI SSIYHQDSAN
YFILEPQHTL SQFAEKVHLK PVDIQQKFFE IMEFICFNLN FVPCKELISI SILLKTQNSI
QCSVLCMKSL LKILRYHKVY KDVFREVGLL EVVVTCLHRY AALLKDSPDS TAKDKISDSQ
KELGFLSMEA LSVLLSGNSN NAGVFRECGG ARCAHNMVPY PECRQQALGI VQQLVLSSGG
DDDMGTLLGL MHTAPVIALE LKTHILKSLL SVLRESHRTR TVFRKVGGFV YVMSVLVSME
GCLAEPPKSP WETAERKDVL TLLKLVFSVL TVAMRYEPAN AKFFATDVQY SSLTNAVRLL
GCFSSQKFLE KPAANMTPSE VQPFEEFFNT LSEEKCPTIP RILQSACLMI RFMHDMVLDA
FDRYRFDSSG GGVAGNESPK SVKKVPSLKE STAPPSQLSS SPKRASTGSV NVSLSLAEIK
PDPVIVHSGA VISMLHLLPA VSFEDDAQLV LDLQVHVASV LKSLLRSERN QQVMCEADMP
HELLSKCTVA LEDESHPLHP PLQYMFERLA AQSLTPKDLR DFMRLGNPLS CAPIEEPDSK
EDPDSPDHTE DSSSSSTAAI GVKRGKHEGK LVPLTRVKCL VSMTTPRDVR FHGSLVTPPF
VQFDMNVEGF GCLYLPSIAP QGPPTPSVVG MGMGSTGDSA VLGGIGAGER VFPPQAGLTY
STWICVDKFS TNSSSEAHPV RLLTVVRNVQ GREESSVCLS ILLHPRDRAL IVSTRETIMT
ASSEAELKAH SRKSGATFDR DPQLGDNTVR IWCPELTQEG QWHHLVLLFN KAGMLKNSNV
SVFVDGEPVN TSKLHYISPN IGVGGTASPS AITSVFAYIG TPPVIRKQSR LVWRQGPCHL
FEDVISQSAV QTIYQLGPNY VGCFQAPSFD DSEIGQPLVS EDRVIFGVYV QPVSNLTIAK
IRKVYNKNDA KTIAKQLSMS AHDSVTPIRI LHNAAGHLSG PARSFGAILM GYIGVRTFCP
KPVAKTLENI GSVSLLMGLI AMADDVEGLY AAVKALVCVV KSNDSIMREM DRTRGYQTLA
MLFKKKRHLL NSHILHLTFS LVGTVDSGRE TTVIPNKTAF EDVLCDLQVW HEAPGDLQRS
LYEHFYELLT ESSEQKTNFK LMHEVGLVQK LLYILPDPNL SDATLQTIAS VFTVLLRGAQ
ESKALLKFGQ FAVSTLPPVN TKEGDLSLEE KVGDEVLEGE AELHSVGSDL PDNSEKVLVY
RIKLRNHLLQ IILKLLYLPN PRMVNQQVSD EIQRVLGFDW LMLFLQGNLH PTTVVLAFKI
LVVMLGNATS LQRFREGLLA GGWLHDTEAV LENRLGVLLG FNVGSGKMKT EKREINTDVC
HIHGFTLLQG LLPKHCYIPE LYLMLMSLLL GQPVKELPLD IQFDIDSVWT YIFGVPASQP
AASLKNHKTE FCPEAAFCIL AMVRAIFNQS WQEADESSWE RVYPVTLLQF LLFLYHNQPD
FVPVCMSSEF LGALASTMFP IKSTSGSRSD VTTPTEEYKP LPGSEPMLVV NSPDNSPSSA
HLCGHPAKKF VTDFMRQIVV DSLSHTNQGK SQPVIDLLLE TAPEQSTRRQ QKEFQTALLK
SLMDHLLAAD ALMGEQAALP ISSSGNYNNV ANNVFYFASR VVDKLWQGMY VRDSKDVFEF
VSKLIAQAKR RASGVSLDPI YKCLNRTILY HLSRPTYAVP AQMSVLDALH RLTSNRSLVF
GPGNYDQEFI GCLCYCLLQL TDDSGIPTVN EETISQNTTW HVAPVHDSDD DLEKEDKKTK
NEEGQILVAA AAKRVWEELY VCKKPAIEEV FKVSLNGGDV GGASRIHTPE LSSVRLQIQE
AASRVWHQFL ENEKRTSLRD SEKLTMQLQS RIQRVGSGAL RLVSRRSRKE IPVKAISLTK
QESITWTMAH IAVVQDLVQL QRNQYMLAQQ HMEKYLLDEW SQVESELMRE RGVWGPPVGS
SLDKWILDMT EGPCRMRKKM LKNDMFYIQY PYIKQDENKP VKYKTAVSRD SAKYYKRFRS
HSLVGDENIP QLQADGSDTP TSVDMETIEE NREGLFNPPS LLRRANSNKS MNSVSSSSVG
GASSAGGGSV DNMMEEDQDT DLLSAEPGAE GNKPDNETLL RLLDEGEKIT HMFRCARIQG
LDTCEGLLLF GKEHFYVVDG FTLLSTREIA DIDSVPPEYH DPIIPTKGTG GTTQKRLCSK
FNYEDIKEVL KRRYLLQPIA IEVFSADGRN FLLSFPKKIR NKVYARFMAV ASSLTDNAQQ
SVAGQKQNAK IEPGTGIISS LIGEKSVTQR WERGEITNFQ YLMYLNTLAG RSYNDLMQYP
VFPWIVADYD SEELDLTQPE TFRDLSKPMG VQTPNRLKQF IKRYKDWDDP TGETPPYHYG
THYSSAMIVA SYLVRMEPFT QHFLRLQGGH FDLADRMFHS VKEMWLSASQ NNMADVKELI
PELFYLPDFL LNSNNFDLGL KQSGVPLGDV ILPPWAKGDP REFIRAHREA LECDYVSAHL
HEWIDLIFGY KQQGPAAVEA VNVFHHLFYE GNVDIYTIDD PLKKNATIGF INNFGQIPKQ
LFKKPHPSKK LNIKQLEPVP VNSPPNSMAD KLFFHNVDNL RPSMQPIKEL KNPVGQILHT
EKAVLAVEQN KVLIPTIFNR YLAWGFADLS LRIGAYDSDK AISVFENLDS NEILCASCPS
ARVLVTGGTS TVVNVWKLGD GKDKRQLSLR RPLYGHTEPV TCIAASAAYN LIVSGSRDRT
CILWDLSRLN FVRQLRGHVA PVAAVAINEL TGDIATCAGT YLYVWNINGE EIAHVNTATS
RNQQILCVEF SQMMEWDSRN VILTGSSDGV VRMYSVEYVQ VPTEEYYRKQ EQAKLRLQVE
KDEEEESKNL SVPKSIPDDN LSACSSTEKL DMQDGDQDSI DYSSSVDEGS NLERYYSREF
STASTATTDG EDGLTRDGSG RGLSDEGGAD TLTRNDSGRN LSDEGGDDTL KRNSGAHIIS
DDSGDGTLKR NSGLHLISDE ALSEASVPSD QAENNSEDVM DGNILTRHNG IEAPKISEPG
VNPSPSISDY VIIDDQDVKS APPSPAHSLL KYSTKGTVKL RDGFKWQRQL VFRSKLTMHT
AYERKDNRDP AAVTALAVSK CHKTVFVGDA KGRVFSWSVT DQPGRVIADH WVRDETSDVC
VACGVKFSFS ERRHHCRNCG QLFCSKCSKF EIEIPRLRIH KPVRVCLACH NILRAQEASD
ALTSKA
//
