ID A0A2R2MKV0_LINUN Unreviewed; 1146 AA.
AC A0A2R2MKV0;
DT 23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT 23-MAY-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Potassium voltage-gated channel subfamily H member 8 {ECO:0000313|RefSeq:XP_023930846.1};
GN Name=LOC106158338 {ECO:0000313|RefSeq:XP_023930846.1};
OS Lingula unguis.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_023930846.1};
RN [1] {ECO:0000313|RefSeq:XP_023930846.1}
RP IDENTIFICATION.
RC TISSUE=Gonads {ECO:0000313|RefSeq:XP_023930846.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_023930846.1; XM_024075078.1.
DR AlphaFoldDB; A0A2R2MKV0; -.
DR STRING; 7574.A0A2R2MKV0; -.
DR EnsemblMetazoa; XM_024075078.1; XP_023930846.1; LOC106158338.
DR KEGG; lak:106158338; -.
DR InParanoid; A0A2R2MKV0; -.
DR OrthoDB; 74296at2759; -.
DR Proteomes; UP000085678; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.10.287.630; Helix hairpin bin; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR018488; cNMP-bd_CS.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR45638; CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A; 1.
DR PANTHER; PTHR45638:SF7; CYCLIC NUCLEOTIDE-GATED ION CHANNEL-LIKE, ISOFORM E; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS00888; CNMP_BINDING_1; 1.
DR PROSITE; PS00889; CNMP_BINDING_2; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 458..479
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 532..558
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 638..741
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 1..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 166..186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 253..309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 868..905
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1031..1054
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1087..1128
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 29..53
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 881..905
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1146 AA; 129516 MW; 31E9A5EFC3A5380C CRC64;
MEAVAIMAEN GESEVRKRKK KKRHRPPGTV QPINSNKGKP SESLEMLGNH DSNSHMYHTK
EVSPELEVNV TGTQVSVAAE GGMNDEEQSI SPVWLPQQPQ ESDTVNVAAV ENAHISRNVQ
DEYNTKLPLR TRETQPSIMS SKLDQDDYQD LNVQMLDQEL KAALNSPESD ETTCTLPNSN
NGNLIKSDEE EGMIKSEDSQ VISNQDNVLQ VGRQELAKAG MEKENLIEKT DQRVKEISGG
RPTARWKKLQ NTLKATNEVQ RPAGREFKRK SSGMNRQDSF LQRFSTRQRE TDENEDEEEG
QSKTQNKKNK RKWTFVVNPD GDTMFYWLGV QALCALYNLW TLIAREAFPD IQTGSPLAWF
ILDGFMDFMY LTDIAFQFRT GYLEQGLIVY DSKQLALHYV KSHYFKIDIL ALTPLDLLQL
TTGIHPMWRF PRFFKVYRVY QFYYMAESRT IYPNFWRVMN LIHILLLGSH WFAAFYFLIS
KSENFPANDW SYPPLQGEYA SVTRMYLKSL YWSTLTLTTI GDLPPPKNNW EYVFTILSYL
IGVFVFATIV GQVGNVIANR NASRLEFERL LDGAKAYMRN HNVPRDMQTR VQRWYDYAWS
RGRISGGGDI NSLGLLPDKL KTELALHVNL ETLRKVTIFQ ECEPEFLHDL VLKMKAYIFT
PGDLICRKGE VAREMFIIAD GVLEVLSESG EVVTQMVSGD FFGEIGILNL DGGVNRRTAD
VRSVGYSELF VLSREDVLSA LQDHPEAEAF MQEYGRKRLK EIEERRRKKM LQNQVHVAAS
LCQLTKPTWQ VASKKAKKNV KFKDKLTSSD GENEEDLVSP CRVLRASSRR RRFVKGKEYS
QINNLDADDQ AKPLVPCDIQ IKVEMCGSDA SSKEDSDGSE TSPDQNVLPP PAVNSVSVDN
SSSQAPVVHL TVKGTEENME DLPDVGSDEV FEPPEIKYVP TPILLRKKKM THHKLRKTLS
EEIDAIASKC EKKRDCSHYS DIGMPLIPAS PSQKGSMASL RSHSCDCVLS YRDNTPGGSG
GVDLQNLKSF DKSNLNQPQP SGPESTGLST TPAPLSSEAI PKVVVQGNEI GSQDPSSLLT
GLKSVLMQNM DAVMNQFQDK VNMLEDDNRK KAEVIKELES KVKSLQRALL WKSSKETGMT
VPSVDI
//
