ID A0A2R2MNG0_LINUN Unreviewed; 849 AA.
AC A0A2R2MNG0;
DT 23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT 23-MAY-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=LOC106162742 {ECO:0000313|RefSeq:XP_023931750.1};
OS Lingula unguis.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_023931750.1};
RN [1] {ECO:0000313|RefSeq:XP_023931750.1}
RP IDENTIFICATION.
RC TISSUE=Gonads {ECO:0000313|RefSeq:XP_023931750.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class subfamily. {ECO:0000256|ARBA:ARBA00009649}.
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DR RefSeq; XP_023931750.1; XM_024075982.1.
DR AlphaFoldDB; A0A2R2MNG0; -.
DR EnsemblMetazoa; XM_024075982.1; XP_023931750.1; LOC106162742.
DR Proteomes; UP000085678; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13189; FERM_C_PTPN4_PTPN3_like; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd14541; PTPc-N3_4; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014847; FA.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR041783; PTPN3/4_FERM_C.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR45706; TYROSINE-PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR45706:SF4; TYROSINE-PROTEIN PHOSPHATASE; 1.
DR Pfam; PF08736; FA; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00295; B41; 1.
DR SMART; SM01195; FA; 1.
DR SMART; SM01196; FERM_C; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR PROSITE; PS00661; FERM_2; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Reference proteome {ECO:0000313|Proteomes:UP000085678}.
FT DOMAIN 1..249
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 431..517
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 579..835
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 752..826
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 320..387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 325..356
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 363..378
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 849 AA; 97655 MW; 100E160C3753B01A CRC64;
MCVHYCLHIL YLLFQFYFNF PLFLFPPVSV GPPYYFQFGV KFYVSDPSKL SEEYTRYHFF
LQLKKDILEG KLVCPPTTAA LLASYAVQSE LGDYNPEEHT DGYLSEFRFI PNQTENFERE
VSELHKQHKG QMPADAEYNY LDVVKRLDMY GVDVHLARDQ SNMDIQLGVA SAGLVVFQNS
VKINTFSWAK IVKISFKRKQ FFIQLRREIG TNNNDNIDNL IGFYMTSYRS CKNLWKSCVE
HHTFFRLHKP NPPIKKKLLS LGSKFRYSGR TEFQTLEDGK RRARIERTFS RSPSKRYARR
TVGGTTRDVI MDEKNVLDGY RNAPVNNGPV NNHVKQSRSM NSTINLTRNY DGYGRSPRSS
FQDYRRKSNT QWSDNQSEPD EGGFVPPVPA KMQDYYLDEN TSMSQQSFEL PDYHEFVPNG
NGFVDGQGLV VIRMRPDDQG RFGFNVKSVN CRGRDPARPH QGGADQGMPI IVSRVAPGSP
ADLCIPRLNE GDQVLQINRR DVSTHSHEQV VMFIRATREN HSGELELIVR PNVYVGDDPV
EEPEFQYIPD THHISTTTHG DVLAESLLLL QEGIESGAAV AQFEQLYRKK PGMTMNAARL
PENIPKNRYR DISPYDQTRV VIKNGPDYIN ANFVNMEIPG SGIVNRYIAA QGPLPNTVVD
YWEMIWEQQS TLVVMLTTKM ERGRVKCHQY WPNLYETEDL GALQLTCLKE QETPSFAFRE
FLLVNMDTNE ERHIVQMQYI AWPDHGVPDD SSDFLDFVIR VRQNRVGMVE PTVVHCSAGI
GRTGVLITME TAMCLIEANQ PVYPLDIVRQ MRDQRAMLIQ TASQYRFVCE AILRVYSEGI
VKPLDDYQR
//
