ID A0A2R2MRF9_LINUN Unreviewed; 2179 AA.
AC A0A2R2MRF9;
DT 23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT 23-MAY-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Helicase with zinc finger domain 2 {ECO:0000313|RefSeq:XP_023932839.1};
GN Name=LOC106154479 {ECO:0000313|RefSeq:XP_023932839.1};
OS Lingula unguis.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_023932839.1};
RN [1] {ECO:0000313|RefSeq:XP_023932839.1}
RP IDENTIFICATION.
RC TISSUE=Gonads {ECO:0000313|RefSeq:XP_023932839.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_023932839.1; XM_024077071.1.
DR STRING; 7574.A0A2R2MRF9; -.
DR EnsemblMetazoa; XM_024077071.1; XP_023932839.1; LOC106154479.
DR KEGG; lak:106154479; -.
DR InParanoid; A0A2R2MRF9; -.
DR OrthoDB; 5405202at2759; -.
DR Proteomes; UP000085678; Unplaced.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0004540; F:RNA nuclease activity; IEA:InterPro.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001900; RNase_II/R.
DR InterPro; IPR047187; SF1_C_Upf1.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR43788; DNA2/NAM7 HELICASE FAMILY MEMBER; 1.
DR PANTHER; PTHR43788:SF8; HELICASE WITH ZINC FINGER 2; 1.
DR Pfam; PF13086; AAA_11; 1.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF00773; RNB; 1.
DR SMART; SM00955; RNB; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000313|RefSeq:XP_023932839.1};
KW Hydrolase {ECO:0000313|RefSeq:XP_023932839.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000085678}.
FT DOMAIN 698..1058
FT /note="Ribonuclease II/R"
FT /evidence="ECO:0000259|SMART:SM00955"
FT REGION 371..392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1575..1594
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2154..2179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 374..392
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2154..2169
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2179 AA; 248743 MW; 247162952091AA2B CRC64;
MYVPDGLYRR EEALQLVKCQ CFTEANESFS ALIGDILRVA DTGVPTPQRL MVEFYHGRAI
CRFELDLLVE ALGDVHEALR WEKPARILSL PPEIPLIRDA TIRRLLEQLP YWRPRIPELI
KKLHSFGDDS FQQKEFVHAL LCYRDVLILS GVVRECQIMN KQTTARLLLG YSECCLEIAK
TDMDVLNQMF AKLCGDHCQK ALGLIESEQN EDECRALCAK AYDLKSRAFH NQGYIKKAIE
MAEEANSIFS SETREKQIRI LKRMQGEIEA KERRESPKYD PDWIAGLVPA SSGRVEKFAY
TKKSTKSNKT TTTHDRRNRQ ATTASNIMAA TETGRRFPET IASIEMDLGQ PMTEEDLADL
RRLFYEKTRK QFPSRVPEQS TGATQNEKAA CTPTTAVVEY EPLEESMIHV APPVFPDEEE
EKNTLDQEVM ETDFNDALYE DPFSESFEND DFGDHGNLYD FHSKFMLEKK LREDPSKYKL
CTLYIETNQK AHAIPIGTNE QIPRIELYGR IRSGLAFNES IVVVEVFNPP ENDPIPSHTY
RGKVIGVWLE PRVKKFSRFA CTIDDYRSNL AKPICRTAPK IELLGFPDNV REKDEADVPI
YSVEYDGQLK YKKKMKIEAK YKDDIILLVR YLKWKPFRVF PLGVAVGVLK GSASLEREMR
LLMIQHDLVK TFPTHVADRV KALSKKHKKI PVHEFKKRLD YRGVVTLTID PADTRDIDDA
LSVEDIGDYR TRIGVHIADV THFVKKDDFI DKEARARGVS FYPPSDQPRI FMLPDELTTS
MCSLVEGEDR LALSVFFDFD QNGNMLSEPT IKRTVVKSKQ KLSYEEAEMI LCGTGLENEI
SNALKQLHHI ASKCRAQRLK EGSAFNQFQD NGAPMAHVTV EEFMILANVT IGRSLGESFQ
HVLLRVQDPP MDLALQMWQK EFNQVAKHSA ALKKYRLKYG ANAPSGLKQV QQQGQLGTLY
VREAVWKKAL EVSRKGAGQE LLDIFSREHH VPLIYSAHWK INELQRPARM AACSSTAIPS
QDKGHHGLNM TDYTWFTSPI RRYVDIVVHR FVHAMLDKSV DTPPYSQKEL EDICKEMNAL
HRKAKKFHGA CELIQFCLQL KENKTSTILP VVTALDDSFI QLCLPCCKDI PSRHLRLRFG
SMGLNQRPSL DKGTGAVFQF CPLRWKKRLY DRVAVPKPPG GKRQKQRAQD WHDVNPNQFL
TPMPVGVWDG IIEAVSQQNA QALSTLIKMK HKTIANMAQR ENELFSANIN TDAYRKSDGT
IANKESKFQL KVTLGTVVRV LAQAKFHRGS LCPRLSLMSL SPNVHICLKH HDDPVACFCD
ISPVKPLDET YTDEKTYQST LIPLLQIEGA QAAVIDEVSL TVSNVRVSWM KKNANWYGSV
VLGDTFCEDR GIRLSSSQED DGDAAANPDR IVDTGEYRGY VCIVYRNLPP DSQCVSDSGA
TGDCPIDHQS THSEPSSRSI CLPQYNSDAE STWLGHGLIV HVRRRDKRVV FKLLDGIIPE
TIESKSNPKL ATVEFLDRIM PSIRMENAVR SLGEATILAR NIALGKADLR DVINDRDWKD
VEAFFYLHEE DPKKRMERER KKRREPSRVK PEDLLDRRTR YSKGRYLENY LPRANKRQRE
AVISAIMKPF SLIQGPPGTG KTLTGIRLAY LFVEWNRRNS PEERKHVLYC GPSNKSVDVV
ADFFKKKFTP QQYDPNDERP SICPKILRVY GKSLVNRDFP IPKEPDLLRG KDAVSTERHK
DIALHHLIRS KGTKISKDIL ELDAKFKSYF KDPVKNDVSL EIINHYKRLV AQAEEDEIKQ
HDVILCTCTT AGSKAVLRSG IIEQSIVDES GMCVEPDCLV PIVHSKAKQI VLIGDHKQLR
PIVLNQLARD MGLERSLFER YATQFPKQTI MLNKQYRMHP DICDFPSSEF YDGQLYSPPV
LRFASDPMFR DFTPAAEVLW PRIRQGPMLI EDKRFVMCHV EGEEESLVIS TPEGGEMSKK
NKAEIQEVER IYSILVSKTS LNLSKANIMV LSQYRAQVNG IEKALKERHG EGVQVSTVVA
SQGGEWDIVI FSTVRSIPEY QIVQRPTKGW CKVNLGFITD DHQINVALTR PRRFLIIIGN
KQLLKCDPTF KKLIAHYEEN GRVKDAGEFL PRGIKGTPFY KKLPPRLQRK LDAGEYYQEE
RQRSDDGDNE VKFEDEEGL
//
