ID A0A2R2MSA4_LINUN Unreviewed; 627 AA.
AC A0A2R2MSA4;
DT 23-MAY-2018, integrated into UniProtKB/TrEMBL.
DT 23-MAY-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=RUN and FYVE domain-containing protein 2 isoform X3 {ECO:0000313|RefSeq:XP_023933145.1};
GN Name=LOC106161606 {ECO:0000313|RefSeq:XP_023933145.1};
OS Lingula unguis.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Brachiopoda; Linguliformea;
OC Lingulata; Lingulida; Linguloidea; Lingulidae; Lingula.
OX NCBI_TaxID=7574 {ECO:0000313|Proteomes:UP000085678, ECO:0000313|RefSeq:XP_023933145.1};
RN [1] {ECO:0000313|RefSeq:XP_023933145.1}
RP IDENTIFICATION.
RC TISSUE=Gonads {ECO:0000313|RefSeq:XP_023933145.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_023933145.1; XM_024077377.1.
DR AlphaFoldDB; A0A2R2MSA4; -.
DR EnsemblMetazoa; XM_024077377.1; XP_023933145.1; LOC106161606.
DR Proteomes; UP000085678; Unplaced.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15721; FYVE_RUFY1_like; 1.
DR CDD; cd17681; RUN_RUFY1_like; 1.
DR Gene3D; 1.20.58.900; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR047335; RUFY1-3.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45956; RUN AND FYVE DOMAIN-CONTAINING PROTEIN 2-LIKE PROTEIN; 1.
DR PANTHER; PTHR45956:SF6; RUN DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF02759; RUN; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00593; RUN; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF140741; RUN domain-like; 1.
DR PROSITE; PS50826; RUN; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000085678};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 96..229
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT DOMAIN 562..620
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 275..334
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 366..449
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 506..557
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 627 AA; 71534 MW; 69A8F26B01CB09B8 CRC64;
MAAPSVEGLP LTDTSSAGGD PGVAKPIATT QKDESSYWPS PVIAFIRGKD PGANKTKPKR
ERRDPMAIER SNLLHVAKLV IKELIDSSLS QGRMLDDDFV PLQQFFVVLE HVLRHGLKPK
KSILRDKREF FPVLEQIEKH VSEAEEITTS VRDMPNLKTP LGRARAFLRL ALMQKRLADY
FKVLIDKKDD VLVDFYEPGA FMLEEEGIVI SGLLVGLNVI DCNICIKEDD LDEPMGVIDF
SLYLKDNSFL GQNEEEDGSE GNAKMAAILD QKNYLEELNR HLNATVTNLQ QKMEAVQTSN
TLMREDLAIS KNNILALQEE NSQLRHEKEG LETSYQRKME GKHRKQDLEK ELELQIGMKT
EMEMAMRLLE KDVHEKQDTV VSLRKQLDEI KQINLELYNK LQACDGSLKH KTELVAKLEE
KTNQMQEAMR AMEARVKQCE SDKIAAEETA RKLGQQLAEK DSRRAALETD LRIEREWRGT
VQKTLEQERG KVSQLQSDLQ QMGKVKQEYS DLMKRHESMK QTCEEQEKAL TELGSHLSES
KLKMEDLREA QQALKEAQWA DDAEATNCKG CTKEFSLSRR KHHCRNCGDI YCSECSDNKM
PLPSSAKPVR VCDNCHTLLL QRYSANK
//
