ID   A0A2R2W7C6_9MICO        Unreviewed;      1075 AA.
AC   A0A2R2W7C6;
DT   20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT   20-JUN-2018, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN   Name=pcrA_1 {ECO:0000313|EMBL:ARC56327.1};
GN   ORFNames=AS850_04455 {ECO:0000313|EMBL:ARC56327.1};
OS   Frondihabitans sp. 762G35.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC   Frondihabitans.
OX   NCBI_TaxID=1446794 {ECO:0000313|EMBL:ARC56327.1, ECO:0000313|Proteomes:UP000264876};
RN   [1] {ECO:0000313|EMBL:ARC56327.1, ECO:0000313|Proteomes:UP000264876}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=762G35 {ECO:0000313|EMBL:ARC56327.1,
RC   ECO:0000313|Proteomes:UP000264876};
RA   Liu Y., Raaijmakers J.M., de Jager V.C.L.;
RT   "Frondihabitans sp. 762G35 genome sequence.";
RL   Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
CC   -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC       {ECO:0000256|ARBA:ARBA00009922}.
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DR   EMBL; CP014619; ARC56327.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2R2W7C6; -.
DR   OrthoDB; 5240387at2; -.
DR   Proteomes; UP000264876; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.160; -; 1.
DR   Gene3D; 3.90.320.10; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011604; PDDEXK-like_dom_sf.
DR   InterPro; IPR038726; PDDEXK_AddAB-type.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070:SF59; DNA HELICASE; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF12705; PDDEXK_1; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000264876}.
FT   DOMAIN          43..341
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   DOMAIN          346..646
FT                   /note="UvrD-like helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51217"
FT   REGION          1..42
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        7..21
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         64..71
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   1075 AA;  113702 MW;  055EB68885EC124B CRC64;
     MSEAPDSVVD VAQTASSPSS RPGFLPVPGR PGAHPGVRDS DAGLDPSQLR VLALADGECA
     AVIGAPGSGK TAALVEFVVD RVHREGWGPS SILALAPTRS TATRLRDVLA ARLDVPTPGP
     LARTVASLAF DVVGHAARVA LSGPPTLLTG GEQDSIIRAL LDGHVEEGTG PEWPEKLGPS
     VRALRGFRTE LRELLMRATE HGVDADGLRR LGRQTDRPEW VAAADFSDEY HRVVDDLGSR
     ALDAAELVDY AVAALDRGET APVVDGLRVV VVDDAQEATE STLSLLRALV RRGVAVVAFG
     DPDLATNAFR GGSPDVLGRL AQRLGIEAVT TIHLESVHRH APRVRALVSS ITDRIGTAGA
     GRQHAARSDV ADDPTVPPLW RIESDTPAHE IAAVGRALRE HHLFSGVPWS RMLVVVRNGA
     LVPSVARSLQ VHEVPTRTPV AGRAVRDEYG ARHLLLAASV ATGRQELAAD VVSELLSGPL
     AGFDALSLRR LRLAIRAEEL AAGGTRSADA LLVEALSGPG RFATIDSRFA ARAGRFATSL
     DSARAEAVAG GSIEEVLWGL WERSGLARDW SEQSRGHGIL AAEADRHLDG VVALFTAAKR
     FVERSPEADA RSFLDQMLGA DVPEDTLSPQ ALSDSVLVTT PSGAIGLEVD VVAVVRLQDG
     IWPNLRVRGG LLEPDGLVEA AQEAQEVLGS DGDTVTSVAD SVDRRAGVLS DELRMFALAT
     SRATRQVILS ATVNDDEAPS MFLRLLPADL PAADVRPPLS LRGLVGHLRH AAVADPSATR
     RDEAASALAR LATEEVAGAS PDEWYGLLAP STEEPLVDLT DPEARVAVSP SQIGSFEECP
     LHWFIDRFGG SAPSSAMGLG TVIHDAMEHA VDIDPVSLWA SVEARWGELE FESAWMSEAE
     RKRARTMTDA LASYLRDFVQ AQGELLGAES SFQVDVGQAL LRGTVDRVEG RADGAVVIVD
     LKTGKSVPTV AEGATNPQLA SYQLALAEGG LEAAPSDSAR GGAKLLFVAK GTRGKPYSER
     WQEAFGDDDL DAFRQRVRGD AAGMADRVFL ARVDDHCTGR FGGSCSIHVV GEVTQ
//