ID A0A2R3MPZ4_9BACE Unreviewed; 125 AA.
AC A0A2R3MPZ4;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase {ECO:0000256|ARBA:ARBA00013253};
DE EC=2.7.6.3 {ECO:0000256|ARBA:ARBA00013253};
GN ORFNames=C3V43_04380 {ECO:0000313|EMBL:AVM57071.1}, EII33_08130
GN {ECO:0000313|EMBL:RRD90661.1}, EV202_10768
GN {ECO:0000313|EMBL:TCO93259.1}, NCTC7812_02884
GN {ECO:0000313|EMBL:VFB15296.1};
OS Bacteroides heparinolyticus.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=28113 {ECO:0000313|EMBL:AVM57071.1, ECO:0000313|Proteomes:UP000237636};
RN [1] {ECO:0000313|EMBL:AVM57071.1, ECO:0000313|Proteomes:UP000237636}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0111 {ECO:0000313|EMBL:AVM57071.1,
RC ECO:0000313|Proteomes:UP000237636};
RA Cohen D.B., Kent A.D.;
RL Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:RRD90661.1, ECO:0000313|Proteomes:UP000279562}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OH1047_COT-310 {ECO:0000313|EMBL:RRD90661.1,
RC ECO:0000313|Proteomes:UP000279562};
RA Coil D.A., Jospin G., Darling A.E., Wallis C., Davis I.J., Harris S.,
RA Eisen J.A., Holcombe L.J., O'Flynn C.;
RT "Genomes From Bacteria Associated with the Canine Oral Cavity: a Test Case
RT for Automated Genome-Based Taxonomic Assignment.";
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:VFB15296.1, ECO:0000313|Proteomes:UP000396835}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3012STDY7078512 {ECO:0000313|EMBL:VFB15296.1,
RC ECO:0000313|Proteomes:UP000396835};
RG Pathogen Informatics;
RL Submitted (FEB-2019) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:TCO93259.1, ECO:0000313|Proteomes:UP000295600}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 23917 {ECO:0000313|EMBL:TCO93259.1,
RC ECO:0000313|Proteomes:UP000295600};
RA Goeker M.;
RT "Genomic Encyclopedia of Type Strains, Phase IV (KMG-IV): sequencing the
RT most valuable type-strain genomes for metagenomic binning, comparative
RT biology and taxonomic classification.";
RL Submitted (MAR-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-
CC 4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-
CC dihydroneopterin triphosphate: step 4/4.
CC {ECO:0000256|ARBA:ARBA00005051}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP027234; AVM57071.1; -; Genomic_DNA.
DR EMBL; RQYF01000034; RRD90661.1; -; Genomic_DNA.
DR EMBL; SLXB01000007; TCO93259.1; -; Genomic_DNA.
DR EMBL; CAACYH010000007; VFB15296.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2R3MPZ4; -.
DR KEGG; bhf:C3V43_04380; -.
DR OrthoDB; 1122272at2; -.
DR UniPathway; UPA00077; UER00155.
DR Proteomes; UP000237636; Chromosome.
DR Proteomes; UP000279562; Unassembled WGS sequence.
DR Proteomes; UP000295600; Unassembled WGS sequence.
DR Proteomes; UP000396835; Unassembled WGS sequence.
DR GO; GO:0003848; F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046656; P:folic acid biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.30.70.560; 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK; 1.
DR InterPro; IPR000550; Hppk.
DR InterPro; IPR035907; Hppk_sf.
DR PANTHER; PTHR43071; 2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE; 1.
DR PANTHER; PTHR43071:SF1; 2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE PYROPHOSPHOKINASE; 1.
DR Pfam; PF01288; HPPK; 1.
DR SUPFAM; SSF55083; 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Folate biosynthesis {ECO:0000256|ARBA:ARBA00022909};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:AVM57071.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000279562};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 5..120
FT /note="7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase"
FT /evidence="ECO:0000259|Pfam:PF01288"
SQ SEQUENCE 125 AA; 14510 MW; 063D1D1CC1D0C839 CRC64;
MVYTISIGSN EQRKENMALA RRRLIELFPG ICFSKEEETS PLLFHRPALF SNQVARFSSE
QQPAEILLRL KAIEREAGRK PEEKKLEIIR LDIDLLSCDD TAYKPEDLKR DYIVHGLEQL
SSGRY
//