ID A0A2R3Z3Q2_9FLAO Unreviewed; 770 AA.
AC A0A2R3Z3Q2;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=peptidoglycan glycosyltransferase {ECO:0000256|ARBA:ARBA00012555};
DE EC=2.4.1.129 {ECO:0000256|ARBA:ARBA00012555};
GN ORFNames=C7S20_06205 {ECO:0000313|EMBL:AVR44891.1};
OS Christiangramia fulva.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Christiangramia.
OX NCBI_TaxID=2126553 {ECO:0000313|EMBL:AVR44891.1, ECO:0000313|Proteomes:UP000241507};
RN [1] {ECO:0000313|Proteomes:UP000241507}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SH35 {ECO:0000313|Proteomes:UP000241507};
RA Hwang S.H., Hwang W.M., Kang K., Ahn T.-Y.;
RT "Gramella fulva sp. nov., isolated from a dry surface of tidal flat.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-
CC Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-
CC (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-
CC cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-
CC D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl
CC diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+);
CC Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033,
CC ChEBI:CHEBI:78435; EC=2.4.1.129;
CC Evidence={ECO:0000256|ARBA:ARBA00023988};
CC -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004752}.
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DR EMBL; CP028136; AVR44891.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2R3Z3Q2; -.
DR KEGG; grs:C7S20_06205; -.
DR OrthoDB; 9766909at2; -.
DR Proteomes; UP000241507; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3810.10; Biosynthetic peptidoglycan transglycosylase-like; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 2.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001264; Glyco_trans_51.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR036950; PBP_transglycosylase.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR32282; BINDING PROTEIN TRANSPEPTIDASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR32282:SF11; PENICILLIN-BINDING PROTEIN 1B; 1.
DR Pfam; PF00912; Transgly; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF53955; Lysozyme-like; 1.
PE 4: Predicted;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000241507};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..45
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 70..245
FT /note="Glycosyl transferase family 51"
FT /evidence="ECO:0000259|Pfam:PF00912"
FT DOMAIN 429..687
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 770 AA; 87201 MW; 144CD62360F4DA06 CRC64;
MAQKSKKTKK STHSNRPYII GFWTLFGIGI LLAIFVFLLA GWGAFGKMPT FEELENPETN
LATEIFSSDG KTLGKYYNEN RTPVKYEDLP EHLVQALVAT EDERFYKHAG IDARGTLRAA
VFLGQRGGAS TITQQLAKQL FTENVSDSFT ERIFQKIKEW VIATRLERQY TKEEIITMYF
NKYDFVYQAV GIRSAAKIYF GKEAKDLNIQ ESAVLVGMLK NAALYNPVRR PDLVEARRNQ
VLEQMNRNGY ISENEMDSLQ KLPMKIEFTP EGHDEGMATY FRAYLQGFMK DWIEKNPKPD
GSHYSLYRDG LKIYTSIDSR MQGYAENAVK KHIAHLQEEF DRQNKNNPTA PFRDIDKSEE
ENIIQQAMRR SDRWYTMKAE GKSEKEILAS FKKPREMRIF SWKGDIDTTM TPRDSILYYK
SFLQAGLMSM EPQTGEVKAW VGGTNFKHFK YDHVKQGKRQ VGSTFKPFVY ATAIDQLKFS
PCDTLPMSRF TIEAGKYGNM KDWSPQNAGN EGYEGMVTLK EGLAKSINTV TARLIDKTGP
QPVIDLAQKL GVDVSNIPAV PAIALGVADI SLFEMVSAFS TFANQGVYVK PVVVNRIEDK
NGTVLYQHTP VTRDVLSKEA AYVTINLLEG VTEAGSGVRL RGTWGKDRID YKRAVTGYPY
DFKNPIAGKT GTTQNQSDGW FIGMVPDLAT GVWVGGEDRS VHFPTITYGQ GATMALPIWG
MYMKDVYADD KLEVSKEEFE KPEDLSIEIN CDNYGRKKTS QSSVPDELDF
//
