ID A0A2R4SY76_9ACTN Unreviewed; 664 AA.
AC A0A2R4SY76;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Acetoacetate--CoA ligase {ECO:0000313|EMBL:AVZ71836.1};
GN ORFNames=SLUN_06150 {ECO:0000313|EMBL:AVZ71836.1};
OS Streptomyces lunaelactis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1535768 {ECO:0000313|EMBL:AVZ71836.1, ECO:0000313|Proteomes:UP000244201};
RN [1] {ECO:0000313|EMBL:AVZ71836.1, ECO:0000313|Proteomes:UP000244201}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MM109 {ECO:0000313|EMBL:AVZ71836.1,
RC ECO:0000313|Proteomes:UP000244201};
RA Naome A., Martinet L., Maciejewska M., Anderssen S., Adam D., Tenconi E.,
RA Deflandre B., Arguelles-Arias A., Calusinska M., Copieters W., Karim L.,
RA Hanikenne M., Baurain D., van Wezel G., Smargiasso N., de Pauw E.,
RA Delfosse P., Rigali S.;
RT "Complete genome sequence of Streptomyces lunaelactis MM109T, a Ferroverdin
RT A producer isolated from cave moonmilk deposits.";
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP026304; AVZ71836.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2R4SY76; -.
DR KEGG; slk:SLUN_06150; -.
DR OrthoDB; 9803968at2; -.
DR Proteomes; UP000244201; Chromosome.
DR GO; GO:0030729; F:acetoacetate-CoA ligase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR CDD; cd05943; AACS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR005914; Acac_CoA_synth.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR NCBIfam; TIGR01217; ac_ac_CoA_syn; 1.
DR PANTHER; PTHR42921; ACETOACETYL-COA SYNTHETASE; 1.
DR PANTHER; PTHR42921:SF1; ACETOACETYL-COA SYNTHETASE; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:AVZ71836.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000244201}.
FT DOMAIN 42..98
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 106..475
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 542..617
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 664 AA; 72980 MW; C44289BD7FF5AB63 CRC64;
MTSAASPAPL WQPDPDRIAA ARITRFQSWA AERYGAPVQG GYAALHRWSV DELETFWRAV
ADWFDVRFSA PYERVLADPA MPGAQWFPGA TLNYAEHALR TAEDPARTHD AALLHVDETH
ETTPISWSEL RRQVGALAAE LRALGVRPGD RVSGYLPNIP QAVTALLATA AVGAVWTSCA
PDFGARSVLD RFQQVEPVIL FTVDGYRYGG KEHDRTETVA ELRSELPTLR AVIHIPLLGT
EAPAGALDWS AVTSGDTEPV FEQVPFDHPL WVLYSSGTTG LPKAIVQSQG GILLEHFKQL
GLHCDLGPED RFFWYTSTGW MMWNFLVSGL LTGTTVVLYD GSPGYPDTGA QWRIAERTEA
TLFGTSAAYV MACRKAEVHP GRDHDLSRIK CVATTGSPLP PDGFRWLHDE VAEDLWIASV
SGGTDVCSCF AGAVPTLPVH IGELQAACLG TDLQSWDPQG KPLIGEVGEL VVTNPMPSMP
IRFWNDPDGS RYRDSYFEMF PGVWRHGDWI TITDRGSVII HGRSDSTLNR QGVRMGSADI
YEAVERLPEI KESLVIGLEE PDGGYWMPLF VHLVDGACLD DGLRARIKQT IREELSPRHV
PDDIIEVPGV PHTLTGKRIE VPVKRLLQGT ALAKAVNPGS VDNLELLRFY EELARTRKAG
PTGD
//
