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Entry: A0A2R4SZD6_9ACTN
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ID   A0A2R4SZD6_9ACTN        Unreviewed;       381 AA.
AC   A0A2R4SZD6;
DT   20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT   20-JUN-2018, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   RecName: Full=Oxygen sensor histidine kinase NreB {ECO:0000256|ARBA:ARBA00017322};
DE            EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
DE   AltName: Full=Nitrogen regulation protein B {ECO:0000256|ARBA:ARBA00030800};
GN   ORFNames=SLUN_08670 {ECO:0000313|EMBL:AVZ72253.1};
OS   Streptomyces lunaelactis.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1535768 {ECO:0000313|EMBL:AVZ72253.1, ECO:0000313|Proteomes:UP000244201};
RN   [1] {ECO:0000313|EMBL:AVZ72253.1, ECO:0000313|Proteomes:UP000244201}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MM109 {ECO:0000313|EMBL:AVZ72253.1,
RC   ECO:0000313|Proteomes:UP000244201};
RA   Naome A., Martinet L., Maciejewska M., Anderssen S., Adam D., Tenconi E.,
RA   Deflandre B., Arguelles-Arias A., Calusinska M., Copieters W., Karim L.,
RA   Hanikenne M., Baurain D., van Wezel G., Smargiasso N., de Pauw E.,
RA   Delfosse P., Rigali S.;
RT   "Complete genome sequence of Streptomyces lunaelactis MM109T, a Ferroverdin
RT   A producer isolated from cave moonmilk deposits.";
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Member of the two-component regulatory system NreB/NreC
CC       involved in the control of dissimilatory nitrate/nitrite reduction in
CC       response to oxygen. NreB functions as a direct oxygen sensor histidine
CC       kinase which is autophosphorylated, in the absence of oxygen, probably
CC       at the conserved histidine residue, and transfers its phosphate group
CC       probably to a conserved aspartate residue of NreC. NreB/NreC activates
CC       the expression of the nitrate (narGHJI) and nitrite (nir) reductase
CC       operons, as well as the putative nitrate transporter gene narT.
CC       {ECO:0000256|ARBA:ARBA00024827}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|ARBA:ARBA00001966};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR   EMBL; CP026304; AVZ72253.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2R4SZD6; -.
DR   KEGG; slk:SLUN_08670; -.
DR   OrthoDB; 144293at2; -.
DR   Proteomes; UP000244201; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   CDD; cd16917; HATPase_UhpB-NarQ-NarX-like; 1.
DR   Gene3D; 1.20.5.1930; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   InterPro; IPR003018; GAF.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   InterPro; IPR011712; Sig_transdc_His_kin_sub3_dim/P.
DR   PANTHER; PTHR24421; NITRATE/NITRITE SENSOR PROTEIN NARX-RELATED; 1.
DR   PANTHER; PTHR24421:SF61; NITROGEN REGULATION PROTEIN B; 1.
DR   Pfam; PF13185; GAF_2; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF07730; HisKA_3; 1.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00065; GAF; 1.
DR   SMART; SM00387; HATPase_c; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF55781; GAF domain-like; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
PE   4: Predicted;
KW   4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022485};
KW   Reference proteome {ECO:0000313|Proteomes:UP000244201};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT   DOMAIN          186..381
FT                   /note="Histidine kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50109"
SQ   SEQUENCE   381 AA;  40628 MW;  73ADE1EB7A4626BA CRC64;
     MSHRPSSGLA AVSTALLAMS RHLEVRDVLK TIVASARELL DAEYAALGVP DDHGGFAQFV
     VDGVSDAQWK AIGPLPRQHG ILASMLRDAK VERLADVRED SRFEGWPSAH PDMSDFLGLP
     VKDGDEVIGA LFLANKRCPK PDGGCGFTAE DEELLSILAQ HAAIALTNAR LYERSRELTI
     AEERSRLAHE LHDAVSQKLF SLRLTAQAAA ALVDRDPARA KGELQQVAGL AAEAADELRA
     AVVELRPAAL DEDGLVNTLR THIQVLDRAH SAKVTFDASG IRALPAAQEE ALLRVAQEAL
     HNALRHSGAD QVDVVLARRG QGAVLGVTDN GKGFEPRTVR RAGRHLGLVS MRDRASGVGG
     RLTVDSAPGK GTTIEMEVPG G
//
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