ID   A0A2R4T7T1_9ACTN        Unreviewed;       107 AA.
AC   A0A2R4T7T1;
DT   20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT   20-JUN-2018, sequence version 1.
DT   24-JAN-2024, entry version 17.
DE   SubName: Full=QacE family quaternary ammonium compound efflux SMR transporter {ECO:0000313|EMBL:AVZ75203.1};
GN   ORFNames=SLUN_26425 {ECO:0000313|EMBL:AVZ75203.1};
OS   Streptomyces lunaelactis.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1535768 {ECO:0000313|EMBL:AVZ75203.1, ECO:0000313|Proteomes:UP000244201};
RN   [1] {ECO:0000313|EMBL:AVZ75203.1, ECO:0000313|Proteomes:UP000244201}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MM109 {ECO:0000313|EMBL:AVZ75203.1,
RC   ECO:0000313|Proteomes:UP000244201};
RA   Naome A., Martinet L., Maciejewska M., Anderssen S., Adam D., Tenconi E.,
RA   Deflandre B., Arguelles-Arias A., Calusinska M., Copieters W., Karim L.,
RA   Hanikenne M., Baurain D., van Wezel G., Smargiasso N., de Pauw E.,
RA   Delfosse P., Rigali S.;
RT   "Complete genome sequence of Streptomyces lunaelactis MM109T, a Ferroverdin
RT   A producer isolated from cave moonmilk deposits.";
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU003942};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003942}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC       superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
CC       {ECO:0000256|RuleBase:RU003942}.
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DR   EMBL; CP026304; AVZ75203.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2R4T7T1; -.
DR   KEGG; slk:SLUN_26425; -.
DR   OrthoDB; 21828at2; -.
DR   Proteomes; UP000244201; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.10.3730.20; -; 1.
DR   InterPro; IPR000390; Small_drug/metabolite_transptr.
DR   InterPro; IPR045324; Small_multidrug_res.
DR   PANTHER; PTHR30561:SF21; MOLECULAR CHAPERONE-RELATED; 1.
DR   PANTHER; PTHR30561; SMR FAMILY PROTON-DEPENDENT DRUG EFFLUX TRANSPORTER SUGE; 1.
DR   Pfam; PF00893; Multi_Drug_Res; 1.
DR   SUPFAM; SSF103481; Multidrug resistance efflux transporter EmrE; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000244201};
KW   Transmembrane {ECO:0000256|RuleBase:RU003942, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        33..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        57..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        84..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   107 AA;  11123 MW;  53BD32829C58B729 CRC64;
     MAWLLVVVAG LLETGFAVCL KLSHGFTRLW PTIAFASFAL GSFGLLTLAL KKLDVGPAYA
     VWTGIGAAGT AIYGMVFLDD LVSTLKIVSI SLVIIGVIGL QLSGSSH
//