ID A0A2R4TFN0_9ACTN Unreviewed; 444 AA.
AC A0A2R4TFN0;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=L-lysine N6-monooxygenase MbtG {ECO:0000256|ARBA:ARBA00016406};
DE EC=1.14.13.59 {ECO:0000256|ARBA:ARBA00013076};
DE AltName: Full=Lysine 6-N-hydroxylase {ECO:0000256|ARBA:ARBA00032738};
DE AltName: Full=Lysine N6-hydroxylase {ECO:0000256|ARBA:ARBA00032493};
DE AltName: Full=Lysine-N-oxygenase {ECO:0000256|ARBA:ARBA00029939};
DE AltName: Full=Mycobactin synthase protein G {ECO:0000256|ARBA:ARBA00031158};
GN ORFNames=SLUN_38425 {ECO:0000313|EMBL:AVZ77913.1};
OS Streptomyces lunaelactis.
OG Plasmid pslun1 {ECO:0000313|Proteomes:UP000244201}.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1535768 {ECO:0000313|EMBL:AVZ77913.1, ECO:0000313|Proteomes:UP000244201};
RN [1] {ECO:0000313|EMBL:AVZ77913.1, ECO:0000313|Proteomes:UP000244201}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MM109 {ECO:0000313|EMBL:AVZ77913.1,
RC ECO:0000313|Proteomes:UP000244201};
RC PLASMID=Plasmid pslun1 {ECO:0000313|Proteomes:UP000244201};
RA Naome A., Martinet L., Maciejewska M., Anderssen S., Adam D., Tenconi E.,
RA Deflandre B., Arguelles-Arias A., Calusinska M., Copieters W., Karim L.,
RA Hanikenne M., Baurain D., van Wezel G., Smargiasso N., de Pauw E.,
RA Delfosse P., Rigali S.;
RT "Complete genome sequence of Streptomyces lunaelactis MM109T, a Ferroverdin
RT A producer isolated from cave moonmilk deposits.";
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysine + NADPH + O2 = H2O + N(6)-hydroxy-L-lysine + NADP(+);
CC Xref=Rhea:RHEA:23228, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:32551, ChEBI:CHEBI:57783, ChEBI:CHEBI:57820,
CC ChEBI:CHEBI:58349; EC=1.14.13.59;
CC Evidence={ECO:0000256|ARBA:ARBA00000168};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- PATHWAY: Siderophore biosynthesis. {ECO:0000256|ARBA:ARBA00004924}.
CC -!- SIMILARITY: Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-
CC oxygenase family. {ECO:0000256|ARBA:ARBA00007588}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP026305; AVZ77913.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2R4TFN0; -.
DR KEGG; slk:SLUN_38425; -.
DR OrthoDB; 7527071at2; -.
DR Proteomes; UP000244201; Plasmid pslun1.
DR GO; GO:0047091; F:L-lysine 6-monooxygenase (NADPH) activity; IEA:UniProtKB-EC.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR025700; Lys/Orn_oxygenase.
DR PANTHER; PTHR42802:SF1; L-ORNITHINE N(5)-MONOOXYGENASE; 1.
DR PANTHER; PTHR42802; MONOOXYGENASE; 1.
DR Pfam; PF13434; Lys_Orn_oxgnase; 1.
DR PRINTS; PR00368; FADPNR.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 2.
PE 3: Inferred from homology;
KW Monooxygenase {ECO:0000313|EMBL:AVZ77913.1};
KW Oxidoreductase {ECO:0000313|EMBL:AVZ77913.1};
KW Plasmid {ECO:0000313|EMBL:AVZ77913.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000244201}.
SQ SEQUENCE 444 AA; 49780 MW; E9F7528DB5D391B9 CRC64;
MGTRAHEIYD VVGIGFGPSN LSLAISLEEH QENVPAHPTR AAFFERQSAF GWHRNMLLPS
ATMQISFLKD LATFRNPVSR FGYVSFLHES GRLARFVNNM DFFPTRLEFH QYLEWAASRF
TDRVSYGSDV TAIRLPQGAG AGSSEYLQVE ARDNATGSTR VVNARNVAIS TGLVPRMPDG
MERDERVWHS SEFLEKYRRM NPGDLKSVAV VGAGQSAAEI TRFLYDSLPH AEVSAIFPSY
GYSVADDTPF ANQIFDPDAV DDYYYGTDKA RESFWRYHKN TNYSVVDSDV IKDLYRRSYD
EDVQGTERLH FLNMTRVREV KRAGDETRVL LDTLLDGHTQ ELDVDAIVFA TGYDSMEPSR
LLGDLDRYCL RDAAGRHRVQ RDNRLVTTPE LSCGIYIQGG TEHTHGLSSA LLSNIAVRSG
EIADSIVGSR PARDRGQPLH AAAV
//
