ID A0A2R4ZNS7_9CREN Unreviewed; 690 AA.
AC A0A2R4ZNS7;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=ATG_04370 {ECO:0000313|EMBL:GAY25234.1};
OS Desulfurococcaceae archaeon AG1.
OC Archaea; Thermoproteota; Thermoprotei; Desulfurococcales;
OC Desulfurococcaceae.
OX NCBI_TaxID=2027460 {ECO:0000313|EMBL:GAY25234.1, ECO:0000313|Proteomes:UP000245022};
RN [1] {ECO:0000313|EMBL:GAY25234.1, ECO:0000313|Proteomes:UP000245022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AG1 {ECO:0000313|EMBL:GAY25234.1,
RC ECO:0000313|Proteomes:UP000245022};
RA Oinishi Y., Fujiwara S., Yumiya M., Fukuyama Y., Omae K., Takashi Y.,
RA Sako Y.;
RT "Draft Genome Sequence of Genus novel archaea, Isolated from Hot Spring in
RT Japan.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAY25234.1}.
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DR EMBL; BEWT01000004; GAY25234.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2R4ZNS7; -.
DR Proteomes; UP000245022; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR PANTHER; PTHR33841:SF4; ENDONUCLEASE-METHYLTRANSFERASE FUSION PROTEIN-RELATED; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000245022};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 99..217
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 690 AA; 78727 MW; CADF349EF05E2C79 CRC64;
MFLRTLNLDG YMHRFEAYEI FVRSLAHILL IKGVKVNTEN VKALLKSLGI GLGRAALSLL
VSDLKNHYKG FSKREIEDLQ YRFPRLMYRD YRRVTASYYS SPLAVELIAR LARDYISSRR
GRVVIADPFM GSGTLLRGVV KRVGIDNIAR IWGMEFDHVA CVFGYASLLD AVGGDIDVRI
ICGDSFKILW RSRAQTPGNK DDWEADVIVT NPPFTRWESL EKNYREYLLR LIRALGYSKY
IVRNQVNLQA LSLFLIDSIL RERGLLLSII PASTFYTIYG RGVKAMLREK YRVLGLFKGW
KPSFSLDSGF MELVIAAIKG EQGETAFVTL SDNCVESIGL SGSIVKGECA SSYTDLGRGS
GVLDMNWLLY FEESSLRPLL RVIEDLLEKD ILLSMREAYG KDLIMRGVEI YGPDFFTIPN
RFWRIVSRSG DVIVIEKIDS GEQLSIPRDY LVEALRRPGL YIDKILVEDP EHYMVSIPPK
DPKKLPQDVR KYIEWGSRSR VATTARRTFG RKWYSHVNRQ IASKNPFGKL FLPDKVDVRL
KGRGVFAIAS TRPISATKNF YILVLSDRIA PLLTLWFNSS VFLTLLIYGG RRIGETWTRL
LIEDYLELPV PNPKICEDHY EEAEDLLRSI GREPLPPIPN QIGRKQRVSI DTLVLEALGV
KGGEELRNHI YNTLSRFLEA SSTNKRYHGA
//
