ID   A0A2R5FV47_NOSCO        Unreviewed;      1048 AA.
AC   A0A2R5FV47;
DT   20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT   20-JUN-2018, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE            EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN   ORFNames=NIES4072_63480 {ECO:0000313|EMBL:GBG22636.1};
OS   Nostoc commune NIES-4072.
OC   Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales; Nostocaceae; Nostoc.
OX   NCBI_TaxID=2005467 {ECO:0000313|EMBL:GBG22636.1, ECO:0000313|Proteomes:UP000245124};
RN   [1] {ECO:0000313|EMBL:GBG22636.1, ECO:0000313|Proteomes:UP000245124}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NIES-4072 {ECO:0000313|EMBL:GBG22636.1,
RC   ECO:0000313|Proteomes:UP000245124};
RA   Hirose Y., Shimura Y., Fujisawa T., Nakamura Y., Kawachi M.;
RT   "Genome sequencing of cyanobaciteial culture collection at National
RT   Institute for Environmental Studies (NIES).";
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC         N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC         COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC         Evidence={ECO:0000256|ARBA:ARBA00001279};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GBG22636.1}.
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DR   EMBL; BDUD01000001; GBG22636.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2R5FV47; -.
DR   OrthoDB; 467945at2; -.
DR   Proteomes; UP000245124; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR   GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   CDD; cd16961; RMtype1_S_TRD-CR_like; 1.
DR   Gene3D; 3.90.220.20; DNA methylase specificity domains; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR003356; DNA_methylase_A-5.
DR   InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR   InterPro; IPR044946; Restrct_endonuc_typeI_TRD_sf.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR42998:SF1; TYPE I RESTRICTION ENZYME HINDI METHYLASE SUBUNIT; 1.
DR   PANTHER; PTHR42998; TYPE I RESTRICTION ENZYME HINDVIIP M PROTEIN-RELATED; 1.
DR   Pfam; PF02384; N6_Mtase; 1.
DR   PRINTS; PR00507; N12N6MTFRASE.
DR   SUPFAM; SSF116734; DNA methylase specificity domain; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS00092; N6_MTASE; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Methyltransferase {ECO:0000313|EMBL:GBG22636.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000245124};
KW   Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW   Transferase {ECO:0000313|EMBL:GBG22636.1}.
FT   DOMAIN          156..399
FT                   /note="DNA methylase adenine-specific"
FT                   /evidence="ECO:0000259|Pfam:PF02384"
SQ   SEQUENCE   1048 AA;  119024 MW;  30E3FB42AC74CC7F CRC64;
     MSKFLSNKPL HDVNSVETAS SKELQQQLKL FSEKTGFMSS DVFDLRSIRL LVSRLHDIFR
     DNDSQSNIIS RFDEITKLVF AKIVSDKTYN SGASTPFSPS DLPLNPCVVR KYYQHLSHQH
     SNLIPKRFSE LHCSDSAIMK CVLALQSFNF TSTQFDVKGL AYEEIVRNTF DKSDHQQFFT
     PPHIVDFIVS ACQPYLKGDI CDPASGTGGF LSSIARHQIN YSSLTSIEID ERLSWVSGIN
     MLLHGAKNIR TVFLPAGGTL GNQANQFFSC FDAIITNPPF GSDFTESDVL ETFELGIGKS
     SRRRGILFIE RCHALLRKNG ILAIILDEGV LNLSHATDVR QFIIKNFDLK AVISLPETAF
     MPYATVNASI LIMSKKIFAE NSKLSVFFAK ADKVGRKTSG DEDIRYDEDG KSYLNSDLPS
     ILNAWHKYLK EGRVDESENI YVADVYSNFD KKTNGHRIDF QYHHPSRKKS QQLIATSIYP
     LKRLADICTE RNVSISPCKE LSGAIIRYTG LANIESNTGQ FEQVPTPSDS LKSSVKMYQP
     GDIIFAKMRP NLRKVALMSF AEPGFVSSEC SVFAANKASD GTYLIDPLIL SVLLRSDFVY
     GQIMHLVAGI GRPRINSKEL LQVMIPLPPK DVQEEIRRQY LSQHQKVENL KSDIGSFLDR
     SQLMLTSLVK ELVCSFIGSP KITSFMPIEN KEMALTAESL RTFLRGESNP LDTLSWLTDL
     FLPEVLKRLN ETDVRRRLGI YAGEKIPENE RNLTDVRNRV SLIIEYEVAR LATRILEDHQ
     IEDIFWSYVV ANRFPDLEVR TSSGSRGLRV EVKCLQTIAE EKSANFDTLR KDIHSLTDFV
     IVFAWDWRYD PEDVTWDRAP FIHHAYAFHA SSLALLRDWY WLNCPPNDLG NGLQGFDLRY
     AVNCKDGTYN EEEGNYGKLL RIWQEGFKYE PPESDLVHRT IADYLAFKNG VIKAGLDTLA
     HLFLPQLSEF NKVVAVLHEN ERVGWQSGEV CFLLSSAVST KKKQNLVLSQ LTVSKVYLFT
     DKYAWREFEY KKGKLTLKRT GKKPKRLI
//