ID A0A2R5G919_9STRA Unreviewed; 1592 AA.
AC A0A2R5G919;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Solute carrier family 12 member 3 {ECO:0000313|EMBL:GBG27552.1};
GN ORFNames=FCC1311_037752 {ECO:0000313|EMBL:GBG27552.1};
OS Hondaea fermentalgiana.
OC Eukaryota; Sar; Stramenopiles; Bigyra; Labyrinthulomycetes;
OC Thraustochytrida; Thraustochytriaceae; Hondaea.
OX NCBI_TaxID=2315210 {ECO:0000313|EMBL:GBG27552.1, ECO:0000313|Proteomes:UP000241890};
RN [1] {ECO:0000313|EMBL:GBG27552.1, ECO:0000313|Proteomes:UP000241890}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Sedici K., Godart F., Aiese Cigliano R., Sanseverino W., Barakat M.,
RA Ortet P., Marechal E., Cagnac O., Amato A.;
RT "Sequencing, de novo assembly and annotation of complete genome of a new
RT Thraustochytrid species, strain FCC1311.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GBG27552.1}.
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DR EMBL; BEYU01000032; GBG27552.1; -; Genomic_DNA.
DR EnsemblProtists; GBG27552; GBG27552; FCC1311_037752.
DR InParanoid; A0A2R5G919; -.
DR Proteomes; UP000241890; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR PANTHER; PTHR11827:SF103; SODIUM CHLORIDE COTRANSPORTER 69, ISOFORM E; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF03522; SLC12; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000241890};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 145..169
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 189..210
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 215..234
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 297..317
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 329..352
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 404..428
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 454..471
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 477..496
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 517..548
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 71..561
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 725..821
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 861..1215
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 604..693
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 826..861
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 919..975
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1071..1136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1225..1246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1325..1364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1434..1454
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 654..668
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 834..856
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 919..933
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1071..1085
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1086..1119
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1120..1136
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1229..1243
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1325..1343
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1592 AA; 171064 MW; DE9E5F2C79083CD5 CRC64;
MTAAVGSPTS LMWSAEGRPT DRVADYGEGI TAGGTMSRLR RGVFRKSRRK PERRFDDDEA
ASSGKLGMIE GVFFRVLTNL FGVILFLRLG WLTAYAGIGL AILVVLLSSS LTLVTALSLS
AICTNGKVAA GGAYYLISRA LGPEFGASIG VLFYVATAVS VSLYLLGFAE TVVSQIGTTL
VSSSWDLRLI AFFGLCFCQL VCLVGVSVVV KVEKFMLLIV IVAVVLFIIG VFIGPDQEPS
LFGFVGLESG LNVGSDFPGA STADPTDLSY LNIAGLTKST QCTVSSSDLL RSEYGNVNLG
IALSVFFPAV TGILAGANIS GDLKNPSSAI PTGTVMAILL GACIYILLVI IFGSSFNRVT
VASATFAQNV TAADGTYELQ YDCVFSGLFH DSTLIAQASV SPGFVYFGIY AASLSSGLAA
LLGAPRILQA LAKDRLFSSF DPLAKGYGRN DEPLRAYVVT FLIATLCILT GDINSVAPLI
TTFFLASYAM VNYACYSAEE SNSPGWRPTF RYFDKWLAFL GAIGCVSVML FLSAITGFIT
FTIGLGLYKY VEVSTREGLG SASSWGPHKE AAEYNTALSS ALLLEEQADP RALSNAVAAS
NIQSPSAGLK RRTSLRSRPS ADAQHTEIEL GGMQNSQREG DDLDGDFNVD VGVGADDELE
RELERNAQRA RNGSMSAREG PRDGGDEDDD DDTLAMAAAG SQFDTTHVKN YRPQCLVLSG
PPRARPALAL FVAGLRKARG VTIFGDVLVG DVSDPSLVRT RNMRASVSYV SQYGIRAFND
VIIAPSFRTG CRSLMQIAGL GRRMRVNTIV LGFLDEWRTP LGERLHSSRK AGADKSGSSR
SFDSRPGANV QEDSDFSPPP SVEDYVGVIG DAFDLGLGVA ILRGEIDLLR SEYLTQTVQT
EMDRVLSLGL ASAGPRFAAQ QGSYQNPNYT NASEYLDAPE HGQGSQRSLD LGGEADGGQA
RNEQGNGGET GASAGNARAP IVTAVGRKSA KRIDVWWFVD DGGLTIMLPH ILRQASSPPW
VGCHLRVMAI GATPEEARVE EAAMVKLLAK LRIPSQVSIV SMSELDTMLQ NSRTRSFSSS
RRPADHGSSG DPDDDDLRRD SLENVALEYD DDEGQQTRRG SAQDEQVGAA SEQGGGNIQR
QLFQAYHSGS SMDPNLNDAT SRQHTYFKVG QLIAAYSSDA LLVVVSLPVP PMSLDPDEYM
KWLDLLSKDA APPVLMSIVT KLRHGEGHGA PSSSTTDSET ELSGRSAAAA DADLEALQHI
MSLTASLDKD LEHMIDKLEK MKLGDFQTNL DKHDPQFVSL VLGRGLKDPD AKPILINAIR
YAPNDESQEE HLATQDAVED TKSDSPKVST SAKANDTGKA SEADEVISAQ AADNAGKAND
IAEADEMKNN VENDKINDAN KAGNGTVKAH ETSEATAANE ESASKVLLKE TEMKIPKEEE
KEENEEKEEK EEEEAPLFFA GEGAFQEMLD EVTSKEGTMK SKGFYERMAS GTLGSAANQN
FKTRNYKSAS VGNQNGPSWK VVSNALRKAG LTFRETPGKE FCQVRECPFC HDIKGDESNM
YKLNVHREHG HFNCFRCGTK GPYTKLQRLL QL
//
