ID A0A2R5HKB7_9LACT Unreviewed; 305 AA.
AC A0A2R5HKB7;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE RecName: Full=UTP--glucose-1-phosphate uridylyltransferase {ECO:0000256|ARBA:ARBA00012415, ECO:0000256|RuleBase:RU361259};
DE EC=2.7.7.9 {ECO:0000256|ARBA:ARBA00012415, ECO:0000256|RuleBase:RU361259};
DE AltName: Full=UDP-glucose pyrophosphorylase {ECO:0000256|RuleBase:RU361259};
GN Name=galU {ECO:0000313|EMBL:GBG97250.1};
GN ORFNames=NtB2_01388 {ECO:0000313|EMBL:GBG97250.1};
OS Lactococcus termiticola.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Lactococcus.
OX NCBI_TaxID=2169526 {ECO:0000313|EMBL:GBG97250.1, ECO:0000313|Proteomes:UP000245021};
RN [1] {ECO:0000313|EMBL:GBG97250.1, ECO:0000313|Proteomes:UP000245021}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NtB2 {ECO:0000313|EMBL:GBG97250.1,
RC ECO:0000313|Proteomes:UP000245021};
RA Noda S., Aihara C., Yuki M., Ohkuma M.;
RT "Draft Genome Sequence of Lactococcus sp. Strain NtB2 (JCM 32569), Isolated
RT from the Gut of the Higher Termite Nasutitermes takasagoensis.";
RL Genome Announc. 6:e00445-18(2018).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-
CC alpha-D-glucose; Xref=Rhea:RHEA:19889, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:46398, ChEBI:CHEBI:58601,
CC ChEBI:CHEBI:58885; EC=2.7.7.9;
CC Evidence={ECO:0000256|ARBA:ARBA00000872,
CC ECO:0000256|RuleBase:RU361259};
CC -!- PATHWAY: Carbohydrate metabolism; nucleotide-sugar metabolism.
CC {ECO:0000256|ARBA:ARBA00005136}.
CC -!- SIMILARITY: Belongs to the UDPGP type 2 family.
CC {ECO:0000256|ARBA:ARBA00006890, ECO:0000256|RuleBase:RU361259}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GBG97250.1}.
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DR EMBL; BFFO01000008; GBG97250.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2R5HKB7; -.
DR OrthoDB; 9803871at2; -.
DR UniPathway; UPA00215; -.
DR Proteomes; UP000245021; Unassembled WGS sequence.
DR GO; GO:0003983; F:UTP:glucose-1-phosphate uridylyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR GO; GO:0006011; P:UDP-glucose metabolic process; IEA:InterPro.
DR CDD; cd02541; UGPase_prokaryotic; 1.
DR InterPro; IPR005771; GalU_uridylyltTrfase_bac/arc.
DR InterPro; IPR005835; NTP_transferase_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR NCBIfam; TIGR01099; galU; 1.
DR PANTHER; PTHR43197; UTP--GLUCOSE-1-PHOSPHATE URIDYLYLTRANSFERASE; 1.
DR PANTHER; PTHR43197:SF1; UTP--GLUCOSE-1-PHOSPHATE URIDYLYLTRANSFERASE; 1.
DR Pfam; PF00483; NTP_transferase; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
KW Nucleotidyltransferase {ECO:0000256|RuleBase:RU361259,
KW ECO:0000313|EMBL:GBG97250.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000245021};
KW Transferase {ECO:0000256|RuleBase:RU361259, ECO:0000313|EMBL:GBG97250.1}.
FT DOMAIN 12..274
FT /note="Nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF00483"
SQ SEQUENCE 305 AA; 33948 MW; 8EBDFC2D76D22DFD CRC64;
MPKVNETVKV RKAIIPAAGL GTRFLPATKA IAKEMLPIVD KPTIQFIVEE ALKSGIEDIL
IVTGKAKRNI EDHFDSNVEL EQNLMEKGKT ELLKLVEETT DINLHFIRQS HPKGLGHAVL
QAKAFVGDEP FVVMLGDDLM DIMGAKVPLT QQLISDYEKT HASTIAVMEV PHEEVDKYGV
IDPEGEVEKG LFNVSKFVEK PAVEDAPSDL AIIGRYLLTP EIFTILENQK PGAGNEIQLT
DAIETLNKTQ RVFARKFTGK RYDVGDKFGF VETSVEYGLN HPQIKDDLEA YIIRKGKELE
AAKKK
//
