ID   A0A2R6NKI7_9APHY        Unreviewed;       372 AA.
AC   A0A2R6NKI7;
DT   20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT   20-JUN-2018, sequence version 1.
DT   24-JAN-2024, entry version 17.
DE   RecName: Full=Nep1-domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=PHLCEN_2v11240 {ECO:0000313|EMBL:PSR72873.1};
OS   Hermanssonia centrifuga.
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Polyporales; Meruliaceae; Hermanssonia.
OX   NCBI_TaxID=98765 {ECO:0000313|EMBL:PSR72873.1, ECO:0000313|Proteomes:UP000186601};
RN   [1] {ECO:0000313|EMBL:PSR72873.1, ECO:0000313|Proteomes:UP000186601}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FBCC195 {ECO:0000313|EMBL:PSR72873.1,
RC   ECO:0000313|Proteomes:UP000186601};
RA   Granchi Z., Peng M., de Vries R.P., Hilden K., Makela M.R., Grigoriev I.,
RA   Riley R.;
RT   "Genome sequence of the basidiomycete white-rot fungus Phlebia
RT   centrifuga.";
RL   Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the class IV-like SAM-binding methyltransferase
CC       superfamily. RNA methyltransferase NEP1 family.
CC       {ECO:0000256|ARBA:ARBA00008115}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PSR72873.1}.
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DR   EMBL; MLYV02001126; PSR72873.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2R6NKI7; -.
DR   STRING; 98765.A0A2R6NKI7; -.
DR   Proteomes; UP000186601; Unassembled WGS sequence.
DR   GO; GO:0070037; F:rRNA (pseudouridine) methyltransferase activity; IEA:InterPro.
DR   GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0070475; P:rRNA base methylation; IEA:InterPro.
DR   CDD; cd18088; Nep1-like; 1.
DR   Gene3D; 3.40.1280.10; -; 1.
DR   InterPro; IPR029028; Alpha/beta_knot_MTases.
DR   InterPro; IPR005304; Rbsml_bgen_MeTrfase_EMG1/NEP1.
DR   InterPro; IPR029026; tRNA_m1G_MTases_N.
DR   PANTHER; PTHR12636; NEP1/MRA1; 1.
DR   PANTHER; PTHR12636:SF5; RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE NEP1; 1.
DR   Pfam; PF03587; EMG1; 1.
DR   SUPFAM; SSF75217; alpha/beta knot; 1.
PE   3: Inferred from homology;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Reference proteome {ECO:0000313|Proteomes:UP000186601};
KW   Ribosome biogenesis {ECO:0000256|ARBA:ARBA00022517};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW   rRNA processing {ECO:0000256|ARBA:ARBA00022552};
KW   rRNA-binding {ECO:0000256|ARBA:ARBA00022730};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   REGION          1..120
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..26
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        74..107
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   372 AA;  40471 MW;  26BE57C1969D3BCA CRC64;
     MSGDNTLPTR RRRQSHSGNI ISPIAVPSGK NRTILSDAPP RPKSTPAHGR PQHRRKQVEG
     EEDETEKEAM QIDDALENSS SSSESSSPPS PVNVLSPSTN NLAADRPTRP LPTSKTRKMA
     VPASNNPLLI PANPHMLPVQ GHVPRNGIAS NQRRLFVILE QACLEAYRVS TGGRSKGGRE
     GDVKYALLNC DDHQGILAKT GRDIADARPD ITHQCLLTLL DSPLNKAGLL QVYIHTAKGV
     LIEVNPHVRI PRTFKRFSGL MVQLLHKLSI RGVNGPEKLL KVIKNPITDH LPANTIKLTL
     SGDAPTIRLS KYLPTLPETH SIAVFVGAMA RGRDDFADGL VDEKISISDY PLSASVACGK
     FCCALEELWD IV
//