ID A0A2R6PG27_9APHY Unreviewed; 613 AA.
AC A0A2R6PG27;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=Sorting nexin MVP1 {ECO:0000256|ARBA:ARBA00014268};
GN ORFNames=PHLCEN_2v4870 {ECO:0000313|EMBL:PSR90577.1};
OS Hermanssonia centrifuga.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Polyporales; Meruliaceae; Hermanssonia.
OX NCBI_TaxID=98765 {ECO:0000313|EMBL:PSR90577.1, ECO:0000313|Proteomes:UP000186601};
RN [1] {ECO:0000313|EMBL:PSR90577.1, ECO:0000313|Proteomes:UP000186601}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FBCC195 {ECO:0000313|EMBL:PSR90577.1,
RC ECO:0000313|Proteomes:UP000186601};
RA Granchi Z., Peng M., de Vries R.P., Hilden K., Makela M.R., Grigoriev I.,
RA Riley R.;
RT "Genome sequence of the basidiomycete white-rot fungus Phlebia
RT centrifuga.";
RL Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for vacuolar protein sorting.
CC {ECO:0000256|ARBA:ARBA00002474}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Membrane {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PSR90577.1}.
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DR EMBL; MLYV02000494; PSR90577.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2R6PG27; -.
DR STRING; 98765.A0A2R6PG27; -.
DR Proteomes; UP000186601; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IEA:InterPro.
DR CDD; cd07597; BAR_SNX8; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR028662; SNX8/Mvp1.
DR InterPro; IPR045734; Snx8_BAR_dom.
DR PANTHER; PTHR47554; SORTING NEXIN MVP1; 1.
DR PANTHER; PTHR47554:SF1; SORTING NEXIN MVP1; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF19566; Snx8_BAR_dom; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50195; PX; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000186601};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 242..348
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 179..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 613 AA; 67965 MW; 91D0827734B1B62B CRC64;
MFNAPRPVQP YGATSASSFG ASFVVDNPLA SSVYDSDGLD PWSSAPSPAP PTLPTSISTT
NASAGFASVI ADATVPEIYH RAFALVDITN TGETSVNGLS RVLGSSSLPA STVERIVSLV
SSRPRVSKLE FFVALALVAL AQSSRDLSIE RVAVLAQEDA LPVPQLDLES LAPSTSAYTP
YRSNAPEVHA PAPTRAFTSD DPWNVSKFPN APTEPPNGAA SMSNGAPSSI SGSGLPKDWW
KKLETVNVNI LGQQGFILNR YLVYEVATDR APPVPRRYSE FVILWDCLVK RYPFRLLPSL
PPKRIGPDDS FLEQRRRGLA RFINFAVNHP VIKEDGLLAV FLTEPSFESW RKHSPISYEE
ESASKRVDRV EEMSIPSDLE EKLAVVRGKI SVLIEQWQKI CILAERMIKR REAAAADSAR
LTNTLKALAE VNERCWRGDD CLLCAGVRQG VSNIAQHTQR HADAMEHRSR TLLYSTLEAL
KSQRDLYIAT RDLFIRHDRL SGDQVEKLKK RVETTSLKLE NVKQAQKDNW QVEADKLAVT
IEKDQAAISA ALNRRVFIRV CMWHELRVVL HNRENTLLTD AVKTFAREER DFSEGITANW
GSLADALETM PYE
//
