ID   A0A2R6QEG6_9APHY        Unreviewed;       892 AA.
AC   A0A2R6QEG6;
DT   20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT   20-JUN-2018, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=Creatinase/aminopeptidase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=PHLCEN_2v3663 {ECO:0000313|EMBL:PSS06533.1};
OS   Hermanssonia centrifuga.
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Polyporales; Meruliaceae; Hermanssonia.
OX   NCBI_TaxID=98765 {ECO:0000313|EMBL:PSS06533.1, ECO:0000313|Proteomes:UP000186601};
RN   [1] {ECO:0000313|EMBL:PSS06533.1, ECO:0000313|Proteomes:UP000186601}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FBCC195 {ECO:0000313|EMBL:PSS06533.1,
RC   ECO:0000313|Proteomes:UP000186601};
RA   Granchi Z., Peng M., de Vries R.P., Hilden K., Makela M.R., Grigoriev I.,
RA   Riley R.;
RT   "Genome sequence of the basidiomycete white-rot fungus Phlebia
RT   centrifuga.";
RL   Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|ARBA:ARBA00001936};
CC   -!- SIMILARITY: Belongs to the peptidase M24B family.
CC       {ECO:0000256|ARBA:ARBA00008766}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PSS06533.1}.
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DR   EMBL; MLYV02000361; PSS06533.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2R6QEG6; -.
DR   STRING; 98765.A0A2R6QEG6; -.
DR   Proteomes; UP000186601; Unassembled WGS sequence.
DR   GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR   CDD; cd01085; APP; 1.
DR   Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR   Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 2.
DR   InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR   InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR   InterPro; IPR000587; Creatinase_N.
DR   InterPro; IPR000994; Pept_M24.
DR   InterPro; IPR033740; Pept_M24B.
DR   InterPro; IPR032416; Peptidase_M24_C.
DR   PANTHER; PTHR43763; XAA-PRO AMINOPEPTIDASE 1; 1.
DR   PANTHER; PTHR43763:SF6; XAA-PRO AMINOPEPTIDASE 1; 1.
DR   Pfam; PF01321; Creatinase_N; 1.
DR   Pfam; PF16189; Creatinase_N_2; 1.
DR   Pfam; PF00557; Peptidase_M24; 1.
DR   Pfam; PF16188; Peptidase_M24_C; 1.
DR   SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR   SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000186601}.
FT   DOMAIN          304..394
FT                   /note="Creatinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01321"
FT   DOMAIN          590..802
FT                   /note="Peptidase M24"
FT                   /evidence="ECO:0000259|Pfam:PF00557"
FT   DOMAIN          815..874
FT                   /note="Peptidase M24 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16188"
FT   REGION          71..272
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        82..100
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        125..143
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        153..177
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        189..204
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        213..272
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   892 AA;  100529 MW;  8D2AF57406BE8601 CRC64;
     MAPPPPPPPP PPLCIPFISK KKTRRLTYTE GNGTESFNSQ RSSIDRLERA GSYSPTATLT
     SRAEKLTFST DTESYYDAPR NFNQAREDRP VLKRANTTKE KPTPKAITNN GGGSRKWGYG
     YGWGIGKKDK EKERDRQMDV QQAREETLDL AMDSSQETRP PMYQSPRGSA DTYHSNPHSD
     HSSPRSHPRS HPRSNPTASP RSNPAGPESI HPRSASLSYT DAMPNNHSRS NHSRSNTTGS
     NATQTTANTK QSSKVSNNLA RRPTLYPSES SSTLVGSALE RKMNDVDSVI PSEDAHGSEY
     VAINDKRREW ISGFTGSAGV AVVSKTSAYL VTDSRYWLQA QRQIDRNWLL VAAGSVDGPK
     DWIEWLVDRA SECRIGIDAR MLSHEKAVLL NNQLAPKRSK LYYPPQNFVD LIWKDKPSRS
     REPVFVQPLK FTGMEAGAKI AQLRQWIQSQ PPTLPSYTKR DAIAGDKQVC TLLSSLSSIA
     WLLNLRGDDI PFNPVFHSYL FVSAEQAILF IEPAKVSAEV DDYLASIGVQ RQEYNAVWTF
     LRQKSWGEGR VIICPQTSYA ISLMLTSLRY TVLPPIIEEW KAVKNQTEVE GMKAAYIRDG
     VAYVRWLAWL EYKMSQGYDI TEYEAAWRLT EFRRMGKYYM GLAYENISAT GKNAALPHYT
     PHKSDEIMIR RDAPYLNDSG GQYRDGTCDT TRTIHFGRPT AEQCEAFTRV LQGHIAIDSA
     IFPEGTNGAQ LDILARKALW QDGLNYMHGT GHGFGSYLNV HEGPHGFSSQ VPLVPGHVIT
     NEPGYYKEDA WGMRIESALF VKRIKTKGEF NGDIWLGFER LTCVPIQTKM IKDSMLSKEE
     RQWLKDHNRR CLEKLEPYLR EDKRALKWLR REAERSIGLA SPGPGGISID WD
//