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Database: UniProt
Entry: A0A2R6S504_9APHY
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ID   A0A2R6S504_9APHY        Unreviewed;       730 AA.
AC   A0A2R6S504;
DT   20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT   20-JUN-2018, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   RecName: Full=ATP-dependent DNA helicase {ECO:0000256|RuleBase:RU367027};
DE            EC=3.6.4.12 {ECO:0000256|RuleBase:RU367027};
DE   Flags: Fragment;
GN   ORFNames=PHLCEN_2v776 {ECO:0000313|EMBL:PSS37374.1};
OS   Hermanssonia centrifuga.
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Polyporales; Meruliaceae; Hermanssonia.
OX   NCBI_TaxID=98765 {ECO:0000313|EMBL:PSS37374.1, ECO:0000313|Proteomes:UP000186601};
RN   [1] {ECO:0000313|EMBL:PSS37374.1, ECO:0000313|Proteomes:UP000186601}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FBCC195 {ECO:0000313|EMBL:PSS37374.1,
RC   ECO:0000313|Proteomes:UP000186601};
RA   Granchi Z., Peng M., de Vries R.P., Hilden K., Makela M.R., Grigoriev I.,
RA   Riley R.;
RT   "Genome sequence of the basidiomycete white-rot fungus Phlebia
RT   centrifuga.";
RL   Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: ATP-dependent DNA helicase involved in DNA damage repair by
CC       homologous recombination and in genome maintenance. Capable of
CC       unwinding D-loops. Plays a role in limiting crossover recombinants
CC       during mitotic DNA double-strand break (DSB) repair. Component of a
CC       FANCM-MHF complex which promotes gene conversion at blocked replication
CC       forks, probably by reversal of the stalled fork.
CC       {ECO:0000256|RuleBase:RU367027}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC         Evidence={ECO:0000256|RuleBase:RU367027};
CC   -!- SUBUNIT: Interacts with the MHF histone-fold complex to form the FANCM-
CC       MHF complex. {ECO:0000256|RuleBase:RU367027}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|RuleBase:RU367027}.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC       FANCM sub-subfamily. {ECO:0000256|ARBA:ARBA00009889,
CC       ECO:0000256|RuleBase:RU367027}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PSS37374.1}.
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DR   EMBL; MLYV02000051; PSS37374.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2R6S504; -.
DR   STRING; 98765.A0A2R6S504; -.
DR   Proteomes; UP000186601; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0043138; F:3'-5' DNA helicase activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   CDD; cd18033; DEXDc_FANCM; 1.
DR   CDD; cd12091; FANCM_ID; 1.
DR   CDD; cd18801; SF2_C_FANCM_Hef; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR039686; FANCM/Mph1-like_ID.
DR   InterPro; IPR044749; FANCM_DEXDc.
DR   InterPro; IPR006935; Helicase/UvrB_N.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR14025; FANCONI ANEMIA GROUP M FANCM FAMILY MEMBER; 1.
DR   PANTHER; PTHR14025:SF20; FANCONI ANEMIA GROUP M PROTEIN; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF04851; ResIII; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000186601}.
FT   DOMAIN          28..196
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          378..559
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
FT   REGION          566..600
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          626..712
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        652..680
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        681..695
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         730
FT                   /evidence="ECO:0000313|EMBL:PSS37374.1"
SQ   SEQUENCE   730 AA;  82309 MW;  40BC6FA08E68D0E9 CRC64;
     MKLHPNLLAA QRWLYPLNQQ RRDYQFNIVK RCLFENTLVA LPTGLGKTFI AGVVMLNFYT
     WFPEGKVVFV APTKPLVAQQ IEACHKTCGI PGSHAAELTG QNSRAVRSRT WQEKRVVYMT
     PQTLMNDLKT DNCDPQDIVL LVIDEAHKGT GDYAYAQVIR YMMAKNPHFR VLALTATPGG
     KPDTVQAIVD ALHISHIEIR DEGSLDLKPY LHKKHIKQHI IEMSDDVRKV RDILSEAMAP
     HIKKLVSAKI LHSHPSPVML HPFSCNMAMQ GLHAGRNGAA WAFSALQKLS GLARAMGYLL
     ESTTNQCYIC LTALVTGDNG TTKQGKQKQN LFKSDPQVQA VIKELEAQKS RLGGFSTHPK
     MDRVKTLLVE HFAQKRYDKE DADANGGSEE LTGDSHVMIF VSFRQCVDEI VEFLNLESPL
     IRAIPFIGQG ADKAGKRGYA QKEQLEVIQK FKSGQFNVLV STSIGEEGLD IGEIDMIICY
     DAQKTPIRML QRVGRTGRKR DGYVHVLLSE VREERNWDKA HVNYEDVQRF IIRAEQLELY
     EDVERLLPEN MKPECIEMEM EIEEYTREEP KAKKGPLPKR PPAKRQPRND DAMRKVPTGA
     SSAFVSVKDL TLKGTKKRKK KGSALIEFDP HAGEDDSDDE EIEAGIFGPR RTQSMPESSK
     QPRQKKLRQS TTMATKEQEK SQATKISHKK KAASIEDLTN NQLEHDGTDD IDDREIEMGL
     SSAHLELLSK
//
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