ID A0A2R6W5V6_MARPO Unreviewed; 637 AA.
AC A0A2R6W5V6;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Tyrosinase copper-binding domain-containing protein {ECO:0000259|PROSITE:PS00497, ECO:0000259|PROSITE:PS00498};
GN ORFNames=MARPO_0145s0009 {ECO:0000313|EMBL:PTQ29241.1};
OS Marchantia polymorpha (Common liverwort) (Marchantia aquatica).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Marchantiophyta;
OC Marchantiopsida; Marchantiidae; Marchantiales; Marchantiaceae; Marchantia.
OX NCBI_TaxID=3197 {ECO:0000313|EMBL:PTQ29241.1, ECO:0000313|Proteomes:UP000244005};
RN [1] {ECO:0000313|Proteomes:UP000244005}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Tak-1 {ECO:0000313|Proteomes:UP000244005};
RX PubMed=28985561; DOI=10.1016/j.cell.2017.09.030;
RA Bowman J.L., Kohchi T., Yamato K.T., Jenkins J., Shu S., Ishizaki K.,
RA Yamaoka S., Nishihama R., Nakamura Y., Berger F., Adam C., Aki S.S.,
RA Althoff F., Araki T., Arteaga-Vazquez M.A., Balasubrmanian S., Barry K.,
RA Bauer D., Boehm C.R., Briginshaw L., Caballero-Perez J., Catarino B.,
RA Chen F., Chiyoda S., Chovatia M., Davies K.M., Delmans M., Demura T.,
RA Dierschke T., Dolan L., Dorantes-Acosta A.E., Eklund D.M., Florent S.N.,
RA Flores-Sandoval E., Fujiyama A., Fukuzawa H., Galik B., Grimanelli D.,
RA Grimwood J., Grossniklaus U., Hamada T., Haseloff J., Hetherington A.J.,
RA Higo A., Hirakawa Y., Hundley H.N., Ikeda Y., Inoue K., Inoue S.I.,
RA Ishida S., Jia Q., Kakita M., Kanazawa T., Kawai Y., Kawashima T.,
RA Kennedy M., Kinose K., Kinoshita T., Kohara Y., Koide E., Komatsu K.,
RA Kopischke S., Kubo M., Kyozuka J., Lagercrantz U., Lin S.S., Lindquist E.,
RA Lipzen A.M., Lu C.W., De Luna E., Martienssen R.A., Minamino N.,
RA Mizutani M., Mizutani M., Mochizuki N., Monte I., Mosher R., Nagasaki H.,
RA Nakagami H., Naramoto S., Nishitani K., Ohtani M., Okamoto T., Okumura M.,
RA Phillips J., Pollak B., Reinders A., Rovekamp M., Sano R., Sawa S.,
RA Schmid M.W., Shirakawa M., Solano R., Spunde A., Suetsugu N., Sugano S.,
RA Sugiyama A., Sun R., Suzuki Y., Takenaka M., Takezawa D., Tomogane H.,
RA Tsuzuki M., Ueda T., Umeda M., Ward J.M., Watanabe Y., Yazaki K.,
RA Yokoyama R., Yoshitake Y., Yotsui I., Zachgo S., Schmutz J.;
RT "Insights into land plant evolution garnered from the Marchantia polymorpha
RT genome.";
RL Cell 171:287-304.e15(2017).
CC -!- COFACTOR:
CC Name=Cu(2+); Xref=ChEBI:CHEBI:29036;
CC Evidence={ECO:0000256|ARBA:ARBA00001973};
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DR EMBL; KZ772815; PTQ29241.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2R6W5V6; -.
DR EnsemblPlants; PTQ29241; PTQ29241; MARPO_0145s0009.
DR Gramene; PTQ29241; PTQ29241; MARPO_0145s0009.
DR Proteomes; UP000244005; Unassembled WGS sequence.
DR GO; GO:0004097; F:catechol oxidase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 1.10.1280.10; Di-copper center containing domain from catechol oxidase; 1.
DR InterPro; IPR008922; Di-copper_centre_dom_sf.
DR InterPro; IPR022740; Polyphenol_oxidase_C.
DR InterPro; IPR022739; Polyphenol_oxidase_cen.
DR InterPro; IPR002227; Tyrosinase_Cu-bd.
DR PANTHER; PTHR11474:SF76; TYROSINASE; 1.
DR PANTHER; PTHR11474; TYROSINASE FAMILY MEMBER; 1.
DR Pfam; PF12142; PPO1_DWL; 1.
DR Pfam; PF12143; PPO1_KFDV; 1.
DR Pfam; PF00264; Tyrosinase; 1.
DR PRINTS; PR00092; TYROSINASE.
DR SUPFAM; SSF48056; Di-copper centre-containing domain; 1.
DR PROSITE; PS00497; TYROSINASE_1; 1.
DR PROSITE; PS00498; TYROSINASE_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000244005};
KW Thioether bond {ECO:0000256|ARBA:ARBA00022784}.
FT DOMAIN 192..209
FT /note="Tyrosinase copper-binding"
FT /evidence="ECO:0000259|PROSITE:PS00497"
FT DOMAIN 375..386
FT /note="Tyrosinase copper-binding"
FT /evidence="ECO:0000259|PROSITE:PS00498"
SQ SEQUENCE 637 AA; 72740 MW; 0BF02C27D70740B3 CRC64;
MRHIHTMASG MSPSGSRVRK TEWIPQSLLH GRQGSGRNSA SKTHQQLKWA VYICAFVLCL
QALLGTVDAD PVLASSLGFC KNVTVLKGAP LHCCLPAPKR TPIRFRFPRI PRTFLGRPIL
RERKPAHIVQ RDPDYVRKYN LAYARMKALP DTDPRSFLNQ WRVHCSFCNE AFKQRRTPGP
LGPETGVVLQ VHYSWTFLPW HRIYLYYHER ILASLINDPT FALPFWNWDN QLDQDAAMMP
AMFFPNFGVQ NSALFDQFRN PNHLPPKILY LGYNSKLEAE GKQNLTDKQI RYENLCVMYN
QVTTKISARD FLGGPYVVGT DNSAATVNVS AGEVPGESGG MESVHNVAHE WTGLINDPEH
PDNEDMGNFI YAARDPIFYS HHSNVDRLWD VWKTIPDKVT RSGNRKRMDY TSRDFLDSEF
TFFDENQDMV IVKIRDSLDS SKLGYKFTDV SESDNMWIYY EPMPAQEYPS NSSDYPAATP
SGYNYIGTDP VSFRLDRRAP TSEDAREKGV KNVDQLQEDV VLERVKIPHL QYARFDVFIN
YPAANRQTRL YMSEFVGTFT HLPSGMVDMS RSVSESSSES EDNFRIVTIR YSVNAALKRL
GITDYNTDIV VTIVSKGARN SSPKTGFTFS NLIQDFQ
//
