ID   A0A2R7YUY2_9ACTN        Unreviewed;       351 AA.
AC   A0A2R7YUY2;
DT   20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT   20-JUN-2018, sequence version 1.
DT   24-JAN-2024, entry version 15.
DE   SubName: Full=Type III polyketide synthase {ECO:0000313|EMBL:PUA80141.1};
GN   ORFNames=C7S10_16505 {ECO:0000313|EMBL:PUA80141.1};
OS   Nocardioides currus.
OC   Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC   Nocardioidaceae; Nocardioides.
OX   NCBI_TaxID=2133958 {ECO:0000313|EMBL:PUA80141.1, ECO:0000313|Proteomes:UP000244867};
RN   [1] {ECO:0000313|EMBL:PUA80141.1, ECO:0000313|Proteomes:UP000244867}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IB-3 {ECO:0000313|EMBL:PUA80141.1,
RC   ECO:0000313|Proteomes:UP000244867};
RA   Keele B.F.;
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC       synthases family. {ECO:0000256|ARBA:ARBA00005531}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PUA80141.1}.
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DR   EMBL; PYXZ01000007; PUA80141.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2R7YUY2; -.
DR   OrthoDB; 9786288at2; -.
DR   Proteomes; UP000244867; Unassembled WGS sequence.
DR   GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   CDD; cd00831; CHS_like; 1.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR012328; Chalcone/stilbene_synt_C.
DR   InterPro; IPR001099; Chalcone/stilbene_synt_N.
DR   InterPro; IPR011141; Polyketide_synthase_type-III.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR11877:SF99; 1,3,6,8-TETRAHYDROXYNAPHTHALENE SYNTHASE; 1.
DR   PANTHER; PTHR11877; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; 1.
DR   Pfam; PF02797; Chal_sti_synt_C; 1.
DR   Pfam; PF00195; Chal_sti_synt_N; 1.
DR   PIRSF; PIRSF000451; PKS_III; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000244867}.
FT   DOMAIN          9..197
FT                   /note="Chalcone/stilbene synthase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00195"
FT   DOMAIN          214..349
FT                   /note="Chalcone/stilbene synthase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02797"
FT   ACT_SITE        138
FT                   /note="Acyl-thioester intermediate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000451-1"
SQ   SEQUENCE   351 AA;  37019 MW;  22B282F819554114 CRC64;
     MRILSARGVL PRHSHPQSEI TEAFADVISQ RSLDRALLKR FHANAGVARR HTVLPLEDYA
     GLGDFGRAND LFIEHAVELG SRALVDALKA ADLTPSDVDL IVTATVTGLA VPSLDARIAA
     VVGLRPDVRR VPLVGLGCVA GAAGIARLND HLVGHPGHTA VLVAVELCSL TVQADDVSVP
     NLVASGLFGD GASAVVAVGD AGPDGPVEVL DSRSRLYPDT ERTMGFDVTG SGLRIVLDAE
     VPSLVEQHLR GDVDAFLADH DLTRDDIGWW VCHPGGPKVI EALEAALEVP REAVQLTWDS
     LARVGNLSSV SVLHVLEDTL RERPPEPGSH GVLMAMGPGF CSELVLLRAT S
//