ID A0A2R7Z0W8_9ACTN Unreviewed; 404 AA.
AC A0A2R7Z0W8;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE RecName: Full=Probable acetyl-CoA acetyltransferase {ECO:0000256|ARBA:ARBA00040529};
DE EC=2.3.1.9 {ECO:0000256|ARBA:ARBA00012705};
GN ORFNames=C7S10_00455 {ECO:0000313|EMBL:PUA82268.1};
OS Nocardioides currus.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Nocardioidaceae; Nocardioides.
OX NCBI_TaxID=2133958 {ECO:0000313|EMBL:PUA82268.1, ECO:0000313|Proteomes:UP000244867};
RN [1] {ECO:0000313|EMBL:PUA82268.1, ECO:0000313|Proteomes:UP000244867}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IB-3 {ECO:0000313|EMBL:PUA82268.1,
RC ECO:0000313|Proteomes:UP000244867};
RA Keele B.F.;
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PUA82268.1}.
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DR EMBL; PYXZ01000001; PUA82268.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2R7Z0W8; -.
DR OrthoDB; 4440515at2; -.
DR Proteomes; UP000244867; Unassembled WGS sequence.
DR GO; GO:0003985; F:acetyl-CoA C-acetyltransferase activity; IEA:UniProtKB-EC.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR18919; ACETYL-COA C-ACYLTRANSFERASE; 1.
DR PANTHER; PTHR18919:SF153; TRIFUNCTIONAL ENZYME SUBUNIT BETA, MITOCHONDRIAL; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557,
KW ECO:0000313|EMBL:PUA82268.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000244867};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:PUA82268.1}.
FT DOMAIN 4..270
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 279..402
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 88
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 359
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 389
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 404 AA; 42350 MW; 8FBD2E29A0D7672C CRC64;
MPDIVICEPI RTPVGRYGGA FASLSAVDLA SHTLRELVTR TGLGEGDVDD VILGNCYPSG
ENPAIGRIAA LDAGLGTGVP GLQLDRRCGS GLQAVLYAAS QIASGAGSVI VAGGVESMSN
VEHYALGLRT GVRSGGVELM DRLVRARETA GGKDHPVPGG MLETAENLRR EYAITREEQD
EFSVRSQQRA GDAHEAGKFA DELVPVTVPG RRGKPDVVVD RDEHPRPETT LEQLAALTPV
RQKIDAESTV TAGNASGQND GAAMCVVTTR EEAERRGLTP LLALKSWAVA GVGPEVMGIG
PVPSTAAALE RAGLTLDEID LIELNEAFAA QVLACLREWK VDATDERLNP NGSGISLGHP
VGATGGRILA TLAHELKRRE ARYGLETMCI GGGQGLTAIF ERVS
//
