ID A0A2R7Z1Y5_9ACTN Unreviewed; 816 AA.
AC A0A2R7Z1Y5;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=UvrABC system protein A {ECO:0000256|ARBA:ARBA00039316};
DE AltName: Full=Excinuclease ABC subunit A {ECO:0000256|ARBA:ARBA00042156};
GN Name=uvrA {ECO:0000313|EMBL:PUA82637.1};
GN ORFNames=C7S10_02585 {ECO:0000313|EMBL:PUA82637.1};
OS Nocardioides currus.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Nocardioidaceae; Nocardioides.
OX NCBI_TaxID=2133958 {ECO:0000313|EMBL:PUA82637.1, ECO:0000313|Proteomes:UP000244867};
RN [1] {ECO:0000313|EMBL:PUA82637.1, ECO:0000313|Proteomes:UP000244867}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IB-3 {ECO:0000313|EMBL:PUA82637.1,
RC ECO:0000313|Proteomes:UP000244867};
RA Keele B.F.;
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family.
CC {ECO:0000256|ARBA:ARBA00038000}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PUA82637.1}.
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DR EMBL; PYXZ01000001; PUA82637.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2R7Z1Y5; -.
DR OrthoDB; 9809851at2; -.
DR Proteomes; UP000244867; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR Gene3D; 1.10.8.280; ABC transporter ATPase domain-like; 1.
DR Gene3D; 1.20.1580.10; ABC transporter ATPase like domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004602; UvrA.
DR InterPro; IPR041552; UvrA_DNA-bd.
DR NCBIfam; TIGR00630; uvra; 1.
DR PANTHER; PTHR43152:SF2; DRUG RESISTANCE ABC TRANSPORTER-RELATED; 1.
DR PANTHER; PTHR43152; UVRABC SYSTEM PROTEIN A; 1.
DR Pfam; PF17755; UvrA_DNA-bind; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA excision {ECO:0000256|ARBA:ARBA00022769};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Excision nuclease {ECO:0000256|ARBA:ARBA00022881};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000244867};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 471..799
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 816 AA; 87261 MW; 44E8E3B74A716DE4 CRC64;
MTYDPSDTFV HVRGASEHNL RDVDVDIPRD AMVAFTGVSG SGKSSLAFGT LYAEAQRRYF
ESVAPYARRL LQQVGAPHVQ EITGLPPAVA LQQRRGAPSS RSTVGTITTL SNLLRMLYSR
AGTYPPGAAH LAAEAFSPNT AAGACLRCHG LGVVHDVAED LLVPDPSLSI REGAIAAWPG
AWQGANLRSI VSGLDIDIER PWSRLRKKDR DWLLFTDEQP SVLIKPQRDR IDHGYYGKFW
SARKHVMHVL ADSTSERMRE RALRFVRSVP CPECHGSGLR PEALAVTVAG LSIAEVNAMS
FADVVAVLRP VAELPAEANE VAVRICGDLV ARIDVLLVLG LGYLKLGRSS TTLSPGEAQR
LRIATQLRSG LFGVVYVLDE PSAGLHPADA EPLLDVLARL KASGNSLFVV EHDMDVVRRA
DWVVDIGPGA GEGGGRVLYS GPVAGLEDVE ESATGTYLFG RAEPLDHTPR AAHGHLHLRG
VSRHNLVDVS VDVPLGVLTA VTGVSGSGKS TLVTQVLAEL VRCHLGRAPD DPDQADLEVD
VEDVSGLEAF DRLVLVDQRP IGRTPRSNLA TYTGMFDAVR RLFAATDEAK ARGYGAGRFS
FNVADGRCET CQGEGFVAVE LLFLPGTYAA CPTCHGSRYN AETLEVTHEG RTVADVLAMT
VDDAATFLAD VPAASRSLET LREVGLGYLR LGQPATELSG GEAQRIKLAT ELQRARRGHA
LYLLDEPTAG LHPADIALLL RQLHLLVEAG NTVVLVEHDL DTIATADWVI DLGPGGGDAG
GRVVATGTPR DVASVEGSAT APYLARRLAQ RPRADA
//
