ID   A0A2R7Z2N9_9ACTN        Unreviewed;       503 AA.
AC   A0A2R7Z2N9;
DT   20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT   20-JUN-2018, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=Potassium/proton antiporter {ECO:0000313|EMBL:PUA82897.1};
GN   ORFNames=C7S10_04125 {ECO:0000313|EMBL:PUA82897.1};
OS   Nocardioides currus.
OC   Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC   Nocardioidaceae; Nocardioides.
OX   NCBI_TaxID=2133958 {ECO:0000313|EMBL:PUA82897.1, ECO:0000313|Proteomes:UP000244867};
RN   [1] {ECO:0000313|EMBL:PUA82897.1, ECO:0000313|Proteomes:UP000244867}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IB-3 {ECO:0000313|EMBL:PUA82897.1,
RC   ECO:0000313|Proteomes:UP000244867};
RA   Keele B.F.;
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PUA82897.1}.
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DR   EMBL; PYXZ01000001; PUA82897.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2R7Z2N9; -.
DR   OrthoDB; 9810759at2; -.
DR   Proteomes; UP000244867; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR   GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR   GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR   Gene3D; 1.20.1530.20; -; 1.
DR   Gene3D; 3.30.70.1450; Regulator of K+ conductance, C-terminal domain; 1.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR038770; Na+/solute_symporter_sf.
DR   InterPro; IPR006037; RCK_C.
DR   InterPro; IPR036721; RCK_C_sf.
DR   PANTHER; PTHR32507:SF7; K(+)_H(+) ANTIPORTER NHAP2; 1.
DR   PANTHER; PTHR32507; NA(+)/H(+) ANTIPORTER 1; 1.
DR   Pfam; PF00999; Na_H_Exchanger; 1.
DR   Pfam; PF02080; TrkA_C; 1.
DR   SUPFAM; SSF116726; TrkA C-terminal domain-like; 1.
DR   PROSITE; PS51202; RCK_C; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000244867};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        62..80
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        92..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        122..142
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        190..211
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        223..253
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        274..293
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        299..321
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        333..355
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        367..390
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          403..484
FT                   /note="RCK C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51202"
SQ   SEQUENCE   503 AA;  52499 MW;  D37D4C41D7CECE6B CRC64;
     MTFDVHQLDS FLLVGSLVTL AAILAVRLSA GVGLPSLLFY LLMGVLLGES GLGINFDDAQ
     LAHALGFGAL ALILAEGGLT TSWREMRPSI RLGVSLATLG VAISVAVVAV GAHYLLGLPW
     ELAILLGAVC SPTDAAAVFS VLRVVPLPKR LTGALEAESG LNDAPTVVLV SVISTGAAAE
     SGLVNVAGTI VFELVVGATI GVVAGVGGAW VMRRAALPSS GLYPLAVLCL TFIAYGGAAA
     LHASGFAAVY VAALILGNQE LPHRVATRSF AEGLAWLAQI GLFVMLGLLL SPSRITLEIV
     GYAVVTGLIL TVVARPLSVL VSSVVQPMPW RELGFISWAG LRGAVPIVLT TIPLAEGVEG
     SDRLFDIVFV MVVIYTMLTG PTLPLVARLL GVARRSEPRG LEVEAAPLER LAADLLQVTI
     ADSSRMHGVE VGELRLPPGA SVSLVIRQGQ ALVPERRTVL RHGDDLLVVT PRKAREATEE
     RLRQVSSGGR LAQWLGNGRK PKD
//