ID   A0A2R8AJY6_9RHOB        Unreviewed;       446 AA.
AC   A0A2R8AJY6;
DT   20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT   20-JUN-2018, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   RecName: Full=Zinc metalloprotease {ECO:0000256|RuleBase:RU362031};
DE            EC=3.4.24.- {ECO:0000256|RuleBase:RU362031};
GN   Name=rseP {ECO:0000313|EMBL:SPF76372.1};
GN   ORFNames=ALP8811_01376 {ECO:0000313|EMBL:SPF76372.1};
OS   Aliiroseovarius pelagivivens.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC   Paracoccaceae; Aliiroseovarius.
OX   NCBI_TaxID=1639690 {ECO:0000313|EMBL:SPF76372.1, ECO:0000313|Proteomes:UP000244911};
RN   [1] {ECO:0000313|EMBL:SPF76372.1, ECO:0000313|Proteomes:UP000244911}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CECT 8811 {ECO:0000313|EMBL:SPF76372.1,
RC   ECO:0000313|Proteomes:UP000244911};
RA   Keele B.F.;
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947,
CC         ECO:0000256|RuleBase:RU362031};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the peptidase M50B family.
CC       {ECO:0000256|ARBA:ARBA00007931, ECO:0000256|RuleBase:RU362031}.
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DR   EMBL; OMOI01000001; SPF76372.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2R8AJY6; -.
DR   OrthoDB; 9782003at2; -.
DR   Proteomes; UP000244911; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd00989; PDZ_metalloprotease; 1.
DR   CDD; cd06163; S2P-M50_PDZ_RseP-like; 1.
DR   Gene3D; 2.30.42.10; -; 2.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR041489; PDZ_6.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR004387; Pept_M50_Zn.
DR   InterPro; IPR008915; Peptidase_M50.
DR   NCBIfam; TIGR00054; RIP metalloprotease RseP; 1.
DR   PANTHER; PTHR42837:SF2; MEMBRANE METALLOPROTEASE ARASP2, CHLOROPLASTIC-RELATED; 1.
DR   PANTHER; PTHR42837; REGULATOR OF SIGMA-E PROTEASE RSEP; 1.
DR   Pfam; PF17820; PDZ_6; 1.
DR   Pfam; PF02163; Peptidase_M50; 1.
DR   SMART; SM00228; PDZ; 2.
DR   SUPFAM; SSF50156; PDZ domain-like; 2.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU362031};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362031};
KW   Metal-binding {ECO:0000256|RuleBase:RU362031};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049,
KW   ECO:0000256|RuleBase:RU362031};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000313|EMBL:SPF76372.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000244911};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362031};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362031};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU362031}.
FT   TRANSMEM        12..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362031"
FT   TRANSMEM        114..141
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362031"
FT   TRANSMEM        372..392
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362031"
FT   TRANSMEM        422..440
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362031"
FT   DOMAIN          138..206
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|SMART:SM00228"
FT   DOMAIN          207..275
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|SMART:SM00228"
SQ   SEQUENCE   446 AA;  47190 MW;  8EC6A0DFE6550BD8 CRC64;
     MDLISFLPDF GNLAFTILAF VAALTVIVAV HEYGHYIVGR WSGIKADVFS IGMGPVLFAR
     TDKHGTQWQI AAFPVGGYVK FRGDANAASG GADDAVMAEL SDEDRRHTMH GAPLWARTAT
     VAAGPIFNFI LSILIFAALM MNTGVARDPL AVKTVLDVPG MEQGLREGDK ILSIAGFETP
     PLSEFYEVIE KLPDTARVDY QVERDGQVLT LSATHPYPAL IGSVSPQSAA MAAGLREGDF
     IQSVDGVSVP TFSALREIVV NGDGAELSLG ILRDGTPLDV TLTPRRQDIP AADGGFETRW
     LIGITSGLVF EPATRPAGVW ESLSSGVDRV IFIIQSSLSG LWHMITGAIS SCNLSGPIGI
     AQVSGQVASQ GAVSFVAFIA MLSTAIGMLN LFPIPVLDGG HLVFYAWEAV TGKPPSDKVM
     NVLLAIGLAV VLTVMALGFT NDLFCP
//