ID   A0A2R8B1A3_9RHOB        Unreviewed;      1695 AA.
AC   A0A2R8B1A3;
DT   20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT   20-JUN-2018, sequence version 1.
DT   24-JAN-2024, entry version 17.
DE   SubName: Full=Bifunctional hemolysin/adenylate cyclase {ECO:0000313|EMBL:SPF81954.1};
GN   Name=cya_21 {ECO:0000313|EMBL:SPF81954.1};
GN   ORFNames=PRI8871_03782 {ECO:0000313|EMBL:SPF81954.1};
OS   Pseudoprimorskyibacter insulae.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC   Paracoccaceae; Pseudoprimorskyibacter.
OX   NCBI_TaxID=1695997 {ECO:0000313|EMBL:SPF81954.1, ECO:0000313|Proteomes:UP000244904};
RN   [1] {ECO:0000313|Proteomes:UP000244904}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CECT 8871 {ECO:0000313|Proteomes:UP000244904};
RA   Rodrigo-Torres L., Arahal R. D., Lucena T.;
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR   EMBL; OMOJ01000017; SPF81954.1; -; Genomic_DNA.
DR   OrthoDB; 9773411at2; -.
DR   Proteomes; UP000244904; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   CDD; cd00198; vWFA; 1.
DR   Gene3D; 2.60.120.380; -; 1.
DR   Gene3D; 2.60.40.2700; -; 5.
DR   Gene3D; 2.150.10.10; Serralysin-like metalloprotease, C-terminal; 4.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR018511; Hemolysin-typ_Ca-bd_CS.
DR   InterPro; IPR001343; Hemolysn_Ca-bd.
DR   InterPro; IPR003995; RTX_toxin_determinant-A.
DR   InterPro; IPR011049; Serralysin-like_metalloprot_C.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR38340; S-LAYER PROTEIN; 1.
DR   PANTHER; PTHR38340:SF1; S-LAYER PROTEIN; 1.
DR   Pfam; PF00353; HemolysinCabind; 5.
DR   Pfam; PF13519; VWA_2; 1.
DR   PRINTS; PR00313; CABNDNGRPT.
DR   PRINTS; PR01488; RTXTOXINA.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF51120; beta-Roll; 2.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS00330; HEMOLYSIN_CALCIUM; 5.
DR   PROSITE; PS50234; VWFA; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000244904};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Toxin {ECO:0000256|ARBA:ARBA00022656};
KW   Virulence {ECO:0000256|ARBA:ARBA00023026}.
FT   DOMAIN          1098..1293
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
SQ   SEQUENCE   1695 AA;  177863 MW;  02F00BF01A18B017 CRC64;
     MADDIGETPE TAGAIKVGES ILETLERSGD DDWFAVDLVA GRQYQIDMEG SSSQKGTLFN
     PMIYGVYDAA SDRLPNITYD DDGGYLRDSQ LTFEAQDTGT FYIWARTSNN VSTSQRTGTY
     LLTISNTANL PPLGDVDLIG NAVIGGTLVA ETTGLSDLDG MGALSYQWLR NGAAIEGATT
     DSFTLTDADF GSEVAVAVSY TDGQDNYERI VSAETATVLS TGQMGRLKPT TAGFDIDRTY
     YTADQNVTAL AGGGYVAVYE RYQSVWMRLY DSADNPVGQA VEIDFDGQPD VAALKDGGFV
     VVGTKAFSGE AYAEIVAQRY DNTGAAIGDR FVVNSVSQGN QDRASIVTLK DGGYVVVWQS
     SPYNNIAENG QDGSKDGIFG QRFDSAGNAA GGEFQVNTYT ENAQLAPRLT ALNDGGFMVV
     WMSYAQTGSV NGVYAQRYDA SGAAAGAEMK VGTTGTYGQV YPDIAVLKDG STVVVWYSGA
     GVKAAMGQIF DPSGAAVGEE FQISTGTLYN TNGGPSVVAN SDGGFTVVYG DVYAQRFDRF
     GGRVGDEFQA NVDRDGQEIA FSTLYEPTVD VIDDGKLIVS WSNDNFLKAQ IFSDNAYATG
     AVAITGDAAE NQVLTADTSG LRDADGLGAF TYQWLRDGAE IYQETAATYT PDQEDVGTRL
     SVVVSYVDGA GVAETVTSGE TAKVQNVNSA PTGGAALRST IVKSRDGGVL YTDEGAVITV
     ELNSYNNELA DEDGLGEFSY QWLRDGVAID GATNDRLWAQ QVDVGTKISV AVSYVDGQGT
     LETVESNVFV VENVNDTPRG TVLISGTAAE KGELTADASS LSDEDGLGTF HYQWINNGVG
     GTGTPFDIVG ATSETYSPTQ DEVGSQLSVR VTYTDAYGTE ESVTSGKTAE VTNANNLPTG
     GIAIVGRAIQ GQVLTMIPTD LADEDGLNSF TSYQWFRDGI AVTGETGATY TVTTNDFDAF
     LTVQASYVDG FGTTETLTSD RVGFEAFVEM TTTPNSVGMT HLGGGLNEKF SGYDQGDMLA
     GGNGADTILG GDGNDTILGY DATVQIDGAP DQYTHGSAIL DDYSPISVSM TSVSETSAGT
     VTISGFVAPE VFTTEGADIV VVLDVSGSTS SGFSGSISVP DANRDGTSGT ILDAEIVAFD
     SLMKSITNDA RMGDSDVKLI RFSSGANVHA TGTAGADQNN DGLADIVRTS QSLRSTGGTE
     FLPPLDLAIA HFQQSQSDQR ILYFLSDGEA DTAGVPYRVQ QLQALGVDIR TYAVGNSASD
     ENMDIIDDGI RNGSATIVTD PSQLSARLIE STIDQSAIAG VQVLLNGQVV GNYDSSVLKP
     SPFGLRFDLD VDGLTSGDDK VEVRVTAADG KQTTVSVANT IYDAGPTDPD VLYGENGHDS
     IDGGPGQDVL YGGEGADSLI GNYGDDTLDG GVGVDTAIYD LKSDEVTVLR YGDEATVTSA
     FGTDVLRGVE LLQFTDKLVR FSSYSDRALI RDFDLTGTSA NDILRGEEGN DTLRGLDGSD
     TLVGNGGNDV LIGGASEDDI RDVIYGGDGN DSIDGSYGND ELRGDAGNDT ITGGFGVDNI
     IGGDGDDVLT GQAWSDLIFG GTGDDFINGG FGFDRVNGGT GADRFFHLGI FDHGSDWIQD
     YNAAEGDVLM FGQGGATKDQ FQVNFTETPS AGAAGVAEAF VIYRPTGQIL WALIDGEAQR
     EINLLVGGTT HDLLF
//