ID A0A2R8BYE3_9RHOB Unreviewed; 713 AA.
AC A0A2R8BYE3;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=GTP pyrophosphokinase rsh {ECO:0000256|ARBA:ARBA00014315};
DE AltName: Full=(p)ppGpp synthase {ECO:0000256|ARBA:ARBA00032407};
DE AltName: Full=ATP:GTP 3'-pyrophosphotransferase {ECO:0000256|ARBA:ARBA00029754};
GN Name=rsh {ECO:0000313|EMBL:SPJ25195.1};
GN ORFNames=PAA8504_03044 {ECO:0000313|EMBL:SPJ25195.1};
OS Palleronia abyssalis.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Palleronia.
OX NCBI_TaxID=1501240 {ECO:0000313|EMBL:SPJ25195.1, ECO:0000313|Proteomes:UP000244912};
RN [1] {ECO:0000313|EMBL:SPJ25195.1, ECO:0000313|Proteomes:UP000244912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CECT 8504 {ECO:0000313|EMBL:SPJ25195.1,
RC ECO:0000313|Proteomes:UP000244912};
RA Keele B.F.;
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate)
CC is a mediator of the stringent response that coordinates a variety of
CC cellular activities in response to changes in nutritional abundance.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- SIMILARITY: Belongs to the relA/spoT family.
CC {ECO:0000256|RuleBase:RU003847}.
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DR EMBL; ONZF01000007; SPJ25195.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2R8BYE3; -.
DR Proteomes; UP000244912; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00077; HDc; 1.
DR CDD; cd05399; NT_Rel-Spo_like; 1.
DR CDD; cd01668; TGS_RSH; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR004811; RelA/Spo_fam.
DR InterPro; IPR045600; RelA/SpoT_AH_RIS.
DR InterPro; IPR007685; RelA_SpoT.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR012676; TGS-like.
DR InterPro; IPR033655; TGS_RelA/SpoT.
DR NCBIfam; TIGR00691; spoT_relA; 1.
DR PANTHER; PTHR21262:SF31; BIFUNCTIONAL (P)PPGPP SYNTHASE_HYDROLASE SPOT; 1.
DR PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR Pfam; PF13291; ACT_4; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF19296; RelA_AH_RIS; 2.
DR Pfam; PF04607; RelA_SpoT; 1.
DR Pfam; PF02824; TGS; 1.
DR SMART; SM00471; HDc; 1.
DR SMART; SM00954; RelA_SpoT; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81271; TGS-like; 1.
DR PROSITE; PS51671; ACT; 1.
DR PROSITE; PS51831; HD; 1.
DR PROSITE; PS51880; TGS; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000313|EMBL:SPJ25195.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000244912};
KW Transferase {ECO:0000313|EMBL:SPJ25195.1}.
FT DOMAIN 52..151
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
FT DOMAIN 389..454
FT /note="TGS"
FT /evidence="ECO:0000259|PROSITE:PS51880"
FT DOMAIN 634..708
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
SQ SEQUENCE 713 AA; 80225 MW; 62D439AC0AB9CBE7 CRC64;
MDDGAIWLED AERLIARVRS YNPRADIDRI RRAYAYGAAM HEGQFRHSGE PYITHPLAVA
MILAEQQLDD ATLITALLHD TIEDTKSTFG DVADQFGFEI AELVDGVTKL TKLQLTSTET
KQAENFRKLF MAMSRDMRVI LVKLADRLHN MRTIKAMRPD KQAQKARETM DIYAPLAGRM
GMQWMREELE DHAFSVLNPE GRRSIIHRFA TLRREAGDVV DKITRDIRIE LDKAGIKGEV
YGRAKRPFSI WRKMEEKNVG FSRLSDIYGF RVVVASEAEC YSVMGAIHQR WRAVPGRFKD
YISQPKSNGY RSIHTTVSGR DAKRVEVQIR TRAMHEVAET GVAAHWSYRD GERVENPFAV
DPATWVRALT EQFDAADDHA EFLEAVKLEM YSDQVFCFTP KGEVVKLPKG ATPLDFAYAI
HTRIGERAVG AKVDTVRVPL WQKLRNGQSV EILTAEGQTP QASWLDLVTT GRAKSAIRKS
LREADRDRFV RLGTELMRVA FDHVEKRMTD KAIGIAARAL GVPSGEELLA RVGSAELETR
QVIAALFPGV TPRPADEIDA RSAVVGLEPN QPFGRARCCQ PLPGERIVGI SYRGEGVQIH
AIDCEALAQV EDQPERWIDL AWQSGNHPAV HAVTFDMTIS NDAGVLGRIC TLIGSQKANI
SDLKFLERRQ DFYQVLIDVD LRSIEHFHAV RMALEAEANV AMIERVRDPA LSP
//
