ID A0A2R8FDS8_9VIRU Unreviewed; 318 AA.
AC A0A2R8FDS8;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=D-3-phosphoglycerate dehydrogenase type 2 {ECO:0000313|EMBL:SPN79070.1};
GN ORFNames=BRZCDTV_141 {ECO:0000313|EMBL:SPN79070.1};
OS Brazilian cedratvirus IHUMI.
OC Viruses; Pithoviruses.
OX NCBI_TaxID=2126980 {ECO:0000313|EMBL:SPN79070.1};
RN [1] {ECO:0000313|EMBL:SPN79070.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IHUMI-27.7 {ECO:0000313|EMBL:SPN79070.1};
RG Urmite Genomes;
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. {ECO:0000256|ARBA:ARBA00005854}.
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DR EMBL; LT994651; SPN79070.1; -; Genomic_DNA.
DR SMR; A0A2R8FDS8; -.
DR Proteomes; UP000273054; Chromosome scaffold_1.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0008652; P:amino acid biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd12176; PGDH_3; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR029753; D-isomer_DH_CS.
DR InterPro; IPR029752; D-isomer_DH_CS1.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR42789; D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090); 1.
DR PANTHER; PTHR42789:SF1; D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090); 1.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00065; D_2_HYDROXYACID_DH_1; 1.
DR PROSITE; PS00670; D_2_HYDROXYACID_DH_2; 1.
DR PROSITE; PS00671; D_2_HYDROXYACID_DH_3; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000273054}.
FT DOMAIN 4..315
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00389"
FT DOMAIN 107..283
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
SQ SEQUENCE 318 AA; 34756 MW; 5D2AE10BFCC59EA1 CRC64;
MVKVLLLEGV SNKAVSMFTD LGYEVEVEKR KLSEEELIER LQGVSCLGIR SATQVTEKVL
LSTSLLCIGC FCIGYDQVDL GMATKLGIAV FNSPFCNTRS VAELIIGQII NLSRQVGDRN
MELHQGVWNK TSAGCREIRE KTLGIVGYGN IGSQVSVLAE CMGMKIIFYD VVKKLALGNS
KQVPSLQELL SRSDFVTLHV PDTESTVDLI GEKELLWMKP GSCLLNASRG RVVDLHALVD
ALQSKHLSGA YLDVYPNEPV SVYHSWFSKL QNLPNVILTP HIGGSTEEAQ EAIGVDVAEK
LIAFLSCHHV EGSVNLHA
//
