ID A0A2R8M4M5_CALJA Unreviewed; 333 AA.
AC A0A2R8M4M5;
DT 11-DEC-2019, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=Cathepsin V {ECO:0000313|Ensembl:ENSCJAP00000053641.1};
GN Name=CTSV {ECO:0000313|Ensembl:ENSCJAP00000053641.1};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000053641.1, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000053641.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000053641.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Lysosome {ECO:0000256|ARBA:ARBA00004371}.
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
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DR RefSeq; XP_008991802.1; XM_008993554.2.
DR RefSeq; XP_008991811.1; XM_008993563.2.
DR RefSeq; XP_017827650.1; XM_017972161.1.
DR AlphaFoldDB; A0A2R8M4M5; -.
DR STRING; 9483.ENSCJAP00000053641; -.
DR Ensembl; ENSCJAT00000086083.3; ENSCJAP00000053641.1; ENSCJAG00000046004.3.
DR GeneID; 100411470; -.
DR KEGG; cjc:100411470; -.
DR CTD; 1515; -.
DR GeneTree; ENSGT00940000154367; -.
DR InParanoid; A0A2R8M4M5; -.
DR OMA; HNGEYSE; -.
DR OrthoDB; 5472948at2759; -.
DR Proteomes; UP000008225; Chromosome 1.
DR Bgee; ENSCJAG00000046004; Expressed in testis and 2 other cell types or tissues.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd02248; Peptidase_C1A; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR025661; Pept_asp_AS.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR039417; Peptidase_C1A_papain-like.
DR InterPro; IPR013201; Prot_inhib_I29.
DR PANTHER; PTHR12411:SF57; CATHEPSIN L2; 1.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR Pfam; PF08246; Inhibitor_I29; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00848; Inhibitor_I29; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Signal {ECO:0000256|SAM:SignalP};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..333
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023851504"
FT DOMAIN 29..88
FT /note="Cathepsin propeptide inhibitor"
FT /evidence="ECO:0000259|SMART:SM00848"
FT DOMAIN 114..332
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
SQ SEQUENCE 333 AA; 37257 MW; 674D54C3E108A4B6 CRC64;
MNLSLVLAAF CLGIASAAPK FDQNLDTQWY QWKATHRRLY GTNEEGWRRA VWEKNMKMIE
LHNGEYSQGK HGFTMAMNAF GDMTNEEFRQ VMVCFRNQKH KNRKVFRGPL LLNLPKSVDW
RKKGYVTPVK NQKQCGSCWA FSATGALEGQ MFRKTGKLVS LSEQNLVDCS HPQGNQGCNG
GFMNNAFQYV KENGGLDSEA SYPYVAKDGS CKYKPENSVA NDTGFVVIPA HEKELMKAVA
TVGPISVAVD ASHSSFQFYK SGIYFEQDCS SKNLDHGVLV VGYGFEGTNS NNNNYWLIKN
SWGPEWGSNG YIKIAKDRNN HCGIATAASY PIV
//
