ID A0A2R8MDI3_CALJA Unreviewed; 572 AA.
AC A0A2R8MDI3;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=DNA polymerase alpha subunit B {ECO:0000256|ARBA:ARBA00018596, ECO:0000256|PIRNR:PIRNR018300};
GN Name=POLA2 {ECO:0000313|Ensembl:ENSCJAP00000057867.1};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000057867.1, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000057867.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000057867.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Accessory subunit of the DNA polymerase alpha complex (also
CC known as the alpha DNA polymerase-primase complex) which plays an
CC essential role in the initiation of DNA synthesis.
CC {ECO:0000256|PIRNR:PIRNR018300}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR018300}.
CC -!- SIMILARITY: Belongs to the DNA polymerase alpha subunit B family.
CC {ECO:0000256|ARBA:ARBA00007299, ECO:0000256|PIRNR:PIRNR018300}.
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DR AlphaFoldDB; A0A2R8MDI3; -.
DR Ensembl; ENSCJAT00000079306.3; ENSCJAP00000057867.1; ENSCJAG00000002330.5.
DR GeneTree; ENSGT00390000016784; -.
DR Proteomes; UP000008225; Chromosome 11.
DR Bgee; ENSCJAG00000002330; Expressed in testis and 6 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 3.60.21.60; -; 2.
DR Gene3D; 1.10.8.530; DNA polymerase alpha-primase, subunit B, N-terminal domain; 1.
DR InterPro; IPR007185; DNA_pol_a/d/e_bsu.
DR InterPro; IPR043034; DNA_pol_alpha_B_N_sf.
DR InterPro; IPR016722; DNA_pol_alpha_bsu.
DR InterPro; IPR013627; Pol_alpha_B_N.
DR PANTHER; PTHR23061; DNA POLYMERASE 2 ALPHA 70 KDA SUBUNIT; 1.
DR PANTHER; PTHR23061:SF12; DNA POLYMERASE ALPHA SUBUNIT B; 1.
DR Pfam; PF04042; DNA_pol_E_B; 1.
DR Pfam; PF08418; Pol_alpha_B_N; 1.
DR PIRSF; PIRSF018300; DNA_pol_alph_2; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|PIRNR:PIRNR018300}; Nucleus {ECO:0000256|PIRNR:PIRNR018300};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225}.
FT DOMAIN 104..217
FT /note="DNA polymerase alpha subunit B N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08418"
FT DOMAIN 316..523
FT /note="DNA polymerase alpha/delta/epsilon subunit B"
FT /evidence="ECO:0000259|Pfam:PF04042"
FT REGION 110..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 572 AA; 63383 MW; BC579D0AF507A55C CRC64;
MSVSPKQLAE ELQIFGLDCE EALIEKLVEL CVQYGQNEEG MVSELIAFCT STRKDGLTSE
VLNSFEHEFL SKRLSKARHS ACKDTGHAGV RDIVSIQELY PFSISTPETP LTKRSVSTRS
PHQLLSPSSF SPSATPSQKY NSRSNRGEVV TSFGSAQGVS WSGRGGAGNI NLKVLGCPEA
LTGSYKSMFQ KLPDIREVLT YKIEELGSEL KEHYKIEVFT PLLAPAQEPV TLLGQIGCDS
NGKLNNKSVI LEGDREHSSG AQIPVDLSEL KEYSLFPGQV VIMEGINTTG RKLVATKLYE
VHNPQSSVLD FEQTMVLVAC GPYTTSDSIT YDPLLDLIAV INHDRPDVCI LFGPFLDAKH
EQVENCLLTS PFEDVFKQCL RTIIEGTRSS GSHLVFVPSL RDVHHEPVYP QPPFSYSDLS
REDKKQVHFV SEPCSLSING VIFGLTSTDL LFHLGAEEIS SSSGTSDRFS RIFKHILTQR
SYYPLYPPQE DMAIDYETFY VYAQLPVTPD IFIIPSELRY FVKDVLGCVC VNPGRLTKGQ
VGGTFARLYI RRLVADGTKR QSPCVAAQVI RI
//
