ID A0A2R8MHR0_CALJA Unreviewed; 370 AA.
AC A0A2R8MHR0;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=ETS variant transcription factor 2 {ECO:0000313|Ensembl:ENSCJAP00000059797.1};
GN Name=ETV2 {ECO:0000313|Ensembl:ENSCJAP00000059797.1};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000059797.1, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000059797.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000059797.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004019}.
CC -!- SIMILARITY: Belongs to the ETS family. {ECO:0000256|ARBA:ARBA00005562,
CC ECO:0000256|RuleBase:RU004019}.
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DR AlphaFoldDB; A0A2R8MHR0; -.
DR STRING; 9483.ENSCJAP00000059797; -.
DR Ensembl; ENSCJAT00000082467.2; ENSCJAP00000059797.1; ENSCJAG00000041554.2.
DR GeneTree; ENSGT00940000162407; -.
DR InParanoid; A0A2R8MHR0; -.
DR OMA; GDWTDLP; -.
DR OrthoDB; 2882052at2759; -.
DR Proteomes; UP000008225; Chromosome 22.
DR Bgee; ENSCJAG00000041554; Expressed in liver and 6 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0001824; P:blastocyst development; IEA:Ensembl.
DR GO; GO:0048514; P:blood vessel morphogenesis; IEA:Ensembl.
DR GO; GO:0030509; P:BMP signaling pathway; IEA:Ensembl.
DR GO; GO:0030218; P:erythrocyte differentiation; IEA:Ensembl.
DR GO; GO:0001707; P:mesoderm formation; IEA:Ensembl.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:Ensembl.
DR GO; GO:0001890; P:placenta development; IEA:Ensembl.
DR GO; GO:0045603; P:positive regulation of endothelial cell differentiation; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR GO; GO:2000382; P:positive regulation of mesoderm development; IEA:Ensembl.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:Ensembl.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000418; Ets_dom.
DR InterPro; IPR046328; ETS_fam.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11849; ETS; 1.
DR PANTHER; PTHR11849:SF206; ETS TRANSLOCATION VARIANT 2; 1.
DR Pfam; PF00178; Ets; 1.
DR PRINTS; PR00454; ETSDOMAIN.
DR SMART; SM00413; ETS; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR PROSITE; PS50061; ETS_DOMAIN_3; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004019};
KW Nucleus {ECO:0000256|RuleBase:RU004019};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225}.
FT DOMAIN 269..349
FT /note="ETS"
FT /evidence="ECO:0000259|PROSITE:PS50061"
FT REGION 210..256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 224..256
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 370 AA; 39571 MW; 86A5D53CA851BCAB CRC64;
MDLWNWDEAS PQEVPPGNKL AGLGRLPGLP QRVWGGCPGG ASADPNPLSP AEGAEFGFYV
PDLALQGDMP TATAETYWKG TSSSLAGFPQ LDWGSALLYP EVPWGEEPDP RALPWSGNWT
DVACTAWDSW SGVSQTLGPA PPGPGSAPAA CSEGAAGQNC VPAAGGAITW SRAQATGSTP
SWDCSVGPDG VTYWGSDLGG EPRTDCAISW GGPEGPDCTT SWNPGLRADG TTSLKGYQSS
ALTPSSEPSL QSDRASLARC PKTNHRGPIQ LWQFLLELLH DGARSGCIRW TGNSREFQLC
DPKEVARLWG ERKRKPGMNY EKLSRGLRYY YRRDIVRKSG GRKYTYRFGG RVPSLAYPDC
AGGGQRAETQ
//
