ID A0A2R8MMJ3_CALJA Unreviewed; 806 AA.
AC A0A2R8MMJ3;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 3.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Adenosylhomocysteinase like 2 {ECO:0000313|Ensembl:ENSCJAP00000062118.3};
GN Name=AHCYL2 {ECO:0000313|Ensembl:ENSCJAP00000062118.3};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000062118.3, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000062118.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000062118.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911};
CC -!- SIMILARITY: Belongs to the adenosylhomocysteinase family.
CC {ECO:0000256|ARBA:ARBA00007122, ECO:0000256|RuleBase:RU004166}.
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DR AlphaFoldDB; A0A2R8MMJ3; -.
DR STRING; 9483.ENSCJAP00000062118; -.
DR Ensembl; ENSCJAT00000070788.3; ENSCJAP00000062118.3; ENSCJAG00000010323.5.
DR GeneTree; ENSGT00950000182981; -.
DR InParanoid; A0A2R8MMJ3; -.
DR OMA; MNSERPP; -.
DR Proteomes; UP000008225; Chromosome 8.
DR Bgee; ENSCJAG00000010323; Expressed in kidney and 6 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:Ensembl.
DR GO; GO:0043005; C:neuron projection; IEA:Ensembl.
DR GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
DR CDD; cd00401; SAHH; 1.
DR Gene3D; 3.40.50.1480; Adenosylhomocysteinase-like; 3.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR042172; Adenosylhomocyst_ase-like_sf.
DR InterPro; IPR000043; Adenosylhomocysteinase-like.
DR InterPro; IPR015878; Ado_hCys_hydrolase_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020082; S-Ado-L-homoCys_hydrolase_CS.
DR NCBIfam; TIGR00936; ahcY; 1.
DR PANTHER; PTHR23420; ADENOSYLHOMOCYSTEINASE; 1.
DR PANTHER; PTHR23420:SF2; ADENOSYLHOMOCYSTEINASE 3; 1.
DR Pfam; PF05221; AdoHcyase; 1.
DR Pfam; PF00670; AdoHcyase_NAD; 1.
DR SMART; SM00996; AdoHcyase; 1.
DR SMART; SM00997; AdoHcyase_NAD; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00738; ADOHCYASE_1; 1.
DR PROSITE; PS00739; ADOHCYASE_2; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW One-carbon metabolism {ECO:0000256|ARBA:ARBA00022563};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225}.
FT DOMAIN 565..726
FT /note="S-adenosyl-L-homocysteine hydrolase NAD binding"
FT /evidence="ECO:0000259|SMART:SM00997"
FT REGION 74..118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 130..191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 234..379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 243..263
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 337..361
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 806 AA; 87201 MW; A32D458677732A3F CRC64;
MPAHVIADVH TRRKFTLSGQ QAIPPPLPLP EGFLAFPPWK PQLLWRPSHP HPLRRVTYPH
SFLLVAGLSD PSLRRNPTFR RKGRKGLQPP GGAAGSAPAA RSVGRGLRSH GLPAACGGEQ
THYRFRGASR EAGPVRGGWG GAGGAGAGRS RKGVGAEAME GRSGGMGEGR GREAGGGADQ
EQEQESEQAV AAEAVMSVQV VSAATAAKVP EVELKDLSPS EAELQLALNT AAVGAMGPPA
GGGDPEAPAP AAERPPAPGP GSGPAAALSP AAGKVPQASA MKRSDPHHHH QRHRDGGEAL
VSHDGTVTEA PRTVKKQIQF ADQKQEFNKR PTKIGRRSLS RSISQSSTDS YSSAASYTDS
SDDETSPRDK QQKNSKGSSD FCVKNIKQAE FGRREIEIAE QEMPALMALR KRAQGEKPLA
GAKIVGCTHI TAQTAVLMET LGALGAQCRW AACNIYSTLN EVAAALAESG FPVFAWKGES
EDDFWWCIDR CVNVEGWQPN MILDDGGDLT HWIYKKYPNM FKKIKGIVEE SVTGVHRLYQ
LSKAGKLCVP AMNVNDSVTK QKFDNLYCCR ESILDGLKRT TDMMFGGKQV VVCGYGEVGK
GCCAALKAMG SIVYVTEIDP ICALQACMDG FRLVKLNEVI RQVDIVITCT GNKNVVTREH
LDRMKNSCIV CNMGHSNTEI DVASLRTPEL TWERVRSQVD HVIWPDGKRI VLLAEGRLLN
LSCSTVPTFV LSITATTQAL ALIELYNAPE GRYKQDVYLL PKKMDEYVAS LHLPTFDAHL
TELTDEQAKY LGLNKNGPFK PNYYRY
//
