ID A0A2R8N817_CALJA Unreviewed; 2344 AA.
AC A0A2R8N817;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Notch receptor 2 {ECO:0000313|Ensembl:ENSCJAP00000061622.2};
GN Name=NOTCH2 {ECO:0000313|Ensembl:ENSCJAP00000061622.2};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000061622.2, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000061622.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000061622.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the NOTCH family.
CC {ECO:0000256|ARBA:ARBA00005847}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR STRING; 9483.ENSCJAP00000061622; -.
DR Ensembl; ENSCJAT00000085679.2; ENSCJAP00000061622.2; ENSCJAG00000019931.6.
DR GeneTree; ENSGT00940000155030; -.
DR InParanoid; A0A2R8N817; -.
DR OrthoDB; 5473534at2759; -.
DR Proteomes; UP000008225; Chromosome 7.
DR Bgee; ENSCJAG00000019931; Expressed in ovary and 6 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043235; C:receptor complex; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR GO; GO:0006915; P:apoptotic process; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0071228; P:cellular response to tumor cell; IEA:InterPro.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0050793; P:regulation of developmental process; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 26.
DR CDD; cd21703; JMTM_Notch2; 1.
DR Gene3D; 3.30.300.320; -; 1.
DR Gene3D; 3.30.70.3310; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 2.10.25.10; Laminin; 32.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR008297; Notch.
DR InterPro; IPR035993; Notch-like_dom_sf.
DR InterPro; IPR022336; Notch_2.
DR InterPro; IPR024600; Notch_C.
DR InterPro; IPR000800; Notch_dom.
DR InterPro; IPR010660; Notch_NOD_dom.
DR InterPro; IPR011656; Notch_NODP_dom.
DR PANTHER; PTHR24044; NOTCH LIGAND FAMILY MEMBER; 1.
DR PANTHER; PTHR24044:SF505; NOTCH RECEPTOR 2; 1.
DR Pfam; PF00023; Ank; 2.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00008; EGF; 20.
DR Pfam; PF07645; EGF_CA; 3.
DR Pfam; PF12661; hEGF; 6.
DR Pfam; PF06816; NOD; 1.
DR Pfam; PF07684; NODP; 1.
DR Pfam; PF00066; Notch; 3.
DR PIRSF; PIRSF002279; Notch; 1.
DR PRINTS; PR00010; EGFBLOOD.
DR PRINTS; PR01452; LNOTCHREPEAT.
DR PRINTS; PR01983; NOTCH.
DR PRINTS; PR01985; NOTCH2.
DR SMART; SM00248; ANK; 6.
DR SMART; SM01334; DUF3454; 1.
DR SMART; SM00181; EGF; 32.
DR SMART; SM00179; EGF_CA; 32.
DR SMART; SM00004; NL; 3.
DR SMART; SM01338; NOD; 1.
DR SMART; SM01339; NODP; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 13.
DR SUPFAM; SSF57184; Growth factor receptor domain; 6.
DR SUPFAM; SSF90193; Notch domain; 2.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 4.
DR PROSITE; PS00010; ASX_HYDROXYL; 22.
DR PROSITE; PS00022; EGF_1; 30.
DR PROSITE; PS01186; EGF_2; 25.
DR PROSITE; PS50026; EGF_3; 32.
DR PROSITE; PS01187; EGF_CA; 9.
DR PROSITE; PS50258; LNR; 3.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Calcium {ECO:0000256|PIRSR:PIRSR002279-1};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR002279-2};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR002279-1};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1552..1574
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 18..54
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 56..93
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 95..132
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 134..170
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 172..210
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 212..248
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 249..287
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 289..328
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 330..366
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 368..404
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 406..442
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 444..479
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 481..517
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 519..554
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 556..592
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 594..629
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 631..667
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 669..705
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 707..745
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 747..783
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 785..821
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 823..859
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 861..897
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 899..935
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 937..973
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 986..1021
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1023..1059
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1061..1097
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1099..1136
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1138..1176
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1178..1217
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1249..1286
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1299..1339
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT DOMAIN 1340..1376
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT DOMAIN 1377..1418
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT REPEAT 1750..1782
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1817..1849
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1850..1882
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1883..1915
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 1627..1662
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1965..2048
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2254..2344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1634..1662
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1997..2012
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2013..2048
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2258..2277
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2293..2321
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 310
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 330
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 333
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 347
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 371
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 385
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 386
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT DISULFID 44..53
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 83..92
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 122..131
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 160..169
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 200..209
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 238..247
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 258..275
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 277..286
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 293..307
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 301..316
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 318..327
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2,
FT ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 334..345
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 339..354
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 356..365
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2,
FT ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 372..383
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 377..392
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 394..403
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2,
FT ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 432..441
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 448..458
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 469..478
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 507..516
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 523..533
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 544..553
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 582..591
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 598..608
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 619..628
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 657..666
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 695..704
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 716..733
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 735..744
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 773..782
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 811..820
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 849..858
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 887..896
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 925..934
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 963..972
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1011..1020
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1049..1058
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1087..1096
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1126..1135
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1147..1164
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1166..1175
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1207..1216
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1257..1274
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1276..1285
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2344 AA; 251252 MW; EB6E906CCE5EC948 CRC64;
MPSRPLSVIL PLGKLCQWTD ACLSHPCANG STCTTVANQF SCKCLTGFTG QKCETDVNEC
DIAGRCQHGG TCLNLPGSYQ CQCPQGFTGQ YCDSPYVPCA PSPCVNGGTC RQTGDFTFEC
NCLPGFEGST CEKNIDDCPN HKCQNGGVCV DGVNTYNCRC PPQWTGQFCT EDVDECLLQP
NACQNGGTCA NRNGGFGCVC VNGWSGDDCS ENIDDCAFAS CTPGSTCIDR VASFSCMCPE
GKAGLLCHLD DACISNPCHK GALCDTNPLN GQYICTCPQG YKGADCTEDV DECAMANSNP
CEHAGKCVNT EGGFHCECLK GYAGPRCEMD INECHSDPCQ NDATCLDKIG GFTCLCMPGF
KGVHCELEIN ECQSNPCVNN GQCVDKVNRF QCLCPPGFTG QVCQIDIDDC SSTPCLNGAK
CIDHPNGYEC QCATGFTGVL CEENIDNCDP DPCHHGQCQD GIDSYTCICS PGYMGTICSD
QIDECYSNPC LNDGRCIDLV NGYQCNCQPG TSGVNCEINF DDCTSNPCVH GICMDGINHY
SCVCSPGFTG QRCNIDIDEC ASNPCRKGAT CVNGVNGFRC ICPEGPHHPS CYSQVNECLS
NPCIHGNCTG GLSGYKCLCD AGWVGINCEV DKNECLSNPC QNGGTCDDLV NGYRCTCPKG
FKGYNCQVNI DECASNPCLN QGTCFDDISG YTCHCVLPYT GKNCQTVLAP CSPNPCENAA
VCKESPNFES YTCLCAPGWQ GQQCTIDIDE CISKPCMNHG LCHNTQGSYM CECPPGFSGM
DCEEDIDDCL ANPCQNGGSC VDGVNTFSCI CLPGFTEDKC QTDVNECLNE PCKNGGTCSD
YVNSYTCKCQ AGFDGVHCEN NIDECTESSC FNGGTCVDGV NSFSCLCPVG FTGPFCLHEI
NECSSHPCLN EGTCVDGLGT YHCTCSLGYT GKNCQTLVNL CSQSPCKNKG TCVQEKAESR
CLCPSGWAGA YCDVPNVSCD IAASSRGVPV EHLCQHSGVC INAGNTHYCQ CPLGYTGSYC
EEQLNECASN PCHHGATCSD FIGGYRCECV PGYQGVNCEY EVDECQNQPC QNGGTCIDLV
NHFKCSCPPG SRGLLCEENI DDCAGGPHCL NGGQCVDRIG GYSCHCLPGF AGERCEGDIN
ECLSDPCSSE GSLDCIQLTN DYLCVCRSAF TGRHCETFID VCPQMPCLNG GTCAVASNMP
DGFICRCPPG FSGARCQSSC GQVKCKKGEQ CVHTASGPRC FCPNPQDCES GCASSPCQHG
GSCHPQRQPP FYSCQCTPPF WGSLCELYTV PPSTPPATCL SQYCADKARD GVCDEACNSH
ACQWDGGDCS LTMENPWANC SSPLPCWDYI NNQCDELCNT AECLFDNFEC QGNSKTCKYD
KYCADHFKDN HCDQGCNSEE CGWDGLDCAA DQPENLAEGT LVIVVLLPPE QLLQDVRSFL
RALGTLLHTN LRIKRDSKGE PMVYPYYGEK SAAMKKQRMT RRSLPGEQEQ EVAGSKVFLE
IDNRQCVQDS DHCFKNTDAA AALLASHAIQ GTLSYPLVSV ISESPAPERT QLLYLLAVAV
VIILFIILLG VIMAKRKRKH GSLWLPEGFT LRRDASNHKR REPVGQDAVG LKNLSVQVSE
ANLIGSGTSE HWVDDEGPQS KKVKAEDEAL LSEEDNPIDR RPWTQQHLEA ADIRRTPSLA
LTPPQAEQEV DVLDVNVRGP DGCTPLMLAS LRGGSSDLSD EDEDAEDSSA NIITDLVYQG
ASLQAQTDRT GEMALHLAAR YSRADAAKRL LDAGADANAQ DNMGRCPLHA AVAADAQGVF
QILIRNRVTD LDARMNDGTT PLILAARLAV EGMVAELINC QADVNAVDDH GKSALHWAAA
VNNVEATLLL LKNGANRDMQ DNKEETPLFL AAREGSYEAA KILLDHFANR DITDHMDRLP
RDVARDRMHH DIVRLLDEYN VTPSPPGTVL TSALSPVICG PNRSFLSLKH TPMGKKSRRP
SAKSTMPTSL PNLAKEAKEA KGSRRKKSVS EKVQLSESSV TLSPVDSLES PHTYVSDTTS
SPLITSPGIL QASPNPMLAT AAPPAPVHAQ HALSFSNLHE IQPLAHGAST VLPSVSQLLS
HHHIVPPGSG SAGSLGRLHP VPVPADWMNR MEVNETQYNE MFGMVLAPAE GTHPGIAPQS
RPPEGKHITT PREPLPPIVT FQLIPKGSIA QPAGAPQPQS TCPPAVAGPL PTMYQIPEMA
RLPSMAFPTA MMPQQDGQVA QTILPAYHPF PASVGKYPTP PSQHSYASSN AAERTPSHSG
HLQGEHPYLT PSPESPDQWS SSSPHSASDW SDVTTSPTPG GAGGQRGPGT HMSEPPHNNM
QVYA
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