ID A0A2R8N9M3_CALJA Unreviewed; 470 AA.
AC A0A2R8N9M3;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Nuclear receptor subfamily 0 group B member 1 {ECO:0000256|ARBA:ARBA00016537};
DE AltName: Full=Nuclear receptor DAX-1 {ECO:0000256|ARBA:ARBA00032987};
GN Name=NR0B1 {ECO:0000313|Ensembl:ENSCJAP00000062558.2};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000062558.2, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000062558.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000062558.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Orphan nuclear receptor. Component of a cascade required for
CC the development of the hypothalamic-pituitary-adrenal-gonadal axis.
CC Acts as a coregulatory protein that inhibits the transcriptional
CC activity of other nuclear receptors through heterodimeric interactions.
CC May also have a role in the development of the embryo and in the
CC maintenance of embryonic stem cell pluripotency.
CC {ECO:0000256|ARBA:ARBA00025648}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR0
CC subfamily. {ECO:0000256|ARBA:ARBA00006647}.
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DR AlphaFoldDB; A0A2R8N9M3; -.
DR Ensembl; ENSCJAT00000072779.3; ENSCJAP00000062558.2; ENSCJAG00000007615.6.
DR GeneTree; ENSGT00390000015719; -.
DR InParanoid; A0A2R8N9M3; -.
DR OMA; MAGEDHQ; -.
DR OrthoDB; 5393882at2759; -.
DR Proteomes; UP000008225; Chromosome X.
DR Bgee; ENSCJAG00000007615; Expressed in testis and 1 other cell type or tissue.
DR GO; GO:0034451; C:centriolar satellite; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:Ensembl.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0005840; C:ribosome; IEA:Ensembl.
DR GO; GO:0032448; F:DNA hairpin binding; IEA:Ensembl.
DR GO; GO:0016922; F:nuclear receptor binding; IEA:Ensembl.
DR GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0003723; F:RNA binding; IEA:Ensembl.
DR GO; GO:0003714; F:transcription corepressor activity; IEA:Ensembl.
DR GO; GO:0030325; P:adrenal gland development; IEA:Ensembl.
DR GO; GO:0035987; P:endodermal cell differentiation; IEA:Ensembl.
DR GO; GO:0033327; P:Leydig cell differentiation; IEA:Ensembl.
DR GO; GO:0030238; P:male sex determination; IEA:Ensembl.
DR GO; GO:0033144; P:negative regulation of intracellular steroid hormone receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0010894; P:negative regulation of steroid biosynthetic process; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0008104; P:protein localization; IEA:Ensembl.
DR GO; GO:0035902; P:response to immobilization stress; IEA:Ensembl.
DR GO; GO:0060008; P:Sertoli cell differentiation; IEA:Ensembl.
DR GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR CDD; cd07350; NR_LBD_Dax1; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR033544; NR0B1/2.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR025900; Nuclear_receptor_repeat.
DR PANTHER; PTHR24081; NUCLEAR RECEPTOR SUBFAMILY 0 GROUP B; 1.
DR PANTHER; PTHR24081:SF1; NUCLEAR RECEPTOR SUBFAMILY 0 GROUP B MEMBER 1; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF14046; NR_Repeat; 4.
DR PRINTS; PR00398; STRDHORMONER.
DR SMART; SM00430; HOLI; 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS51843; NR_LBD; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 205..469
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
SQ SEQUENCE 470 AA; 51847 MW; C8B18441BFC76451 CRC64;
MAGEDHQWQG SILYNMLMSA KQRHAAPEAP EARLGDQCWG CSCGDEPGVG REGLLGGRNV
ALLYRCCFCG KDHPRQGSIL YSMLTSAKQT SAAPKAPEAR LGPCWGCSCG SDPGVGREGL
PGGRPVALLY RCCFCGEDHP RQGSILYSLL TSAKQTHVAP AAPEARPGGA WWDRSYFAQR
PGVREGLSGR QAMALLYRCC FCGEDHPQQG SSLYSMPTST NQMPAALGER PGATWWDISC
GALRPVVLKN PQVVCEAASA GLLKTLRFVK YLPCFQVLPL DQQLVLVRNC WAPLLMLELA
QDHLQFETVE TSEPSMLQKI LTTRRRETGG DDPLPISTLQ PRLAPPAEAR QVPSASQVQA
IKCFLTKCWS LEISTKEYAY LKGTVLFNPD LPGLQCVKYI QGLQWGTQQI LSEHVRMTHR
GQHDRFIELN SALFLLRFIN ANVIAELFFR PIIGTVSMDD MMLEMLCTKL
//
