ID A0A2R8NAK1_CALJA Unreviewed; 1664 AA.
AC A0A2R8NAK1;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Neurexin 3 {ECO:0000313|Ensembl:ENSCJAP00000063354.1};
GN Name=NRXN3 {ECO:0000313|Ensembl:ENSCJAP00000063354.1};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000063354.1, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000063354.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000063354.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Presynaptic cell membrane
CC {ECO:0000256|ARBA:ARBA00035005}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00035005}.
CC -!- SIMILARITY: Belongs to the neurexin family.
CC {ECO:0000256|ARBA:ARBA00010241}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR STRING; 9483.ENSCJAP00000063354; -.
DR Ensembl; ENSCJAT00000082601.3; ENSCJAP00000063354.1; ENSCJAG00000017061.5.
DR GeneTree; ENSGT00940000154618; -.
DR InParanoid; A0A2R8NAK1; -.
DR OMA; TDLKFGS; -.
DR Proteomes; UP000008225; Chromosome 10.
DR Bgee; ENSCJAG00000017061; Expressed in cerebellum and 3 other cell types or tissues.
DR GO; GO:0042734; C:presynaptic membrane; IEA:UniProtKB-SubCell.
DR CDD; cd00054; EGF_CA; 2.
DR CDD; cd00110; LamG; 6.
DR Gene3D; 2.60.120.200; -; 6.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR003585; Neurexin-like.
DR PANTHER; PTHR15036:SF49; AXOTACTIN; 1.
DR PANTHER; PTHR15036; PIKACHURIN-LIKE PROTEIN; 1.
DR Pfam; PF02210; Laminin_G_2; 6.
DR SMART; SM00294; 4.1m; 1.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00282; LamG; 6.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 6.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS50025; LAM_G_DOMAIN; 6.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Heparan sulfate {ECO:0000256|ARBA:ARBA00023207};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Proteoglycan {ECO:0000256|ARBA:ARBA00022974};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1591..1611
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 27..202
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 198..235
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 256..438
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 445..637
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 641..678
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 683..846
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 860..1035
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1038..1075
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1079..1279
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT REGION 1313..1337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1632..1664
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1313..1336
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1646..1664
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1664 AA; 183218 MW; 2B3B95C6A1528296 CRC64;
MSFTLHSVFF TLKVSILLGS LLGLCLGLEF MGLPNQWARY LRWDASTRGD LSFQFKTNVS
TGLLLYLDDG GVCDFLCLSL VDGRIQLRFS MDCAETAVLS NKQVNDSSWH FLMVSRDRLR
TVLLLDGEGQ AGELQPQRPY MDVVSDLFLG GVPADIRPSA LTLDGVQAMP GFKGLILDLK
YGNSEPRLLG SQGVQLDAEG PCGERPCENG GICFLLDGHP TCDCSTTGYG GKLCSEGLSH
LMMSEQGRSK AREENVATFR GSEYLCYDLS QNPIQSSSDE ITLSFKTWQR NGLILHTGKS
ADYVNLALKD GAVSLVINLG SGAFEAIVEP VNGKFNDNAW HDVKVTRNLR QVTISVDGIL
TTTGYTQEDY TMLGSDDFFY VGGSPSTADL PGSPVSNNFM GCLKEVVYKN NDIRLELSRL
ARIGDTKMKI YGEVVFKCEN VATLDPINFE TPEAYISLPK WNTKRMGSIS FDFRTTEPNG
LILFTHGKPQ ERKDARSQKN TKVDFFAVEL LDGNLYLLLD MGSGTIKVKA TQKKANDGEW
YHVDIQRDGR SGTISVNSRR TPFTASGESE ILDLEGDMYL GGLPENRAGL ILPTELWTAM
LNYGYVGCIR DLFIDGRSKN IRQLAEMQNA AGVKSSCSRM SAKQCDSYPC KNNAVCKDGW
NRFICDCTGT GYWGRTCERE ASILSYDGSM YMKIIMPMVM HTEAEDVSFR FMSQRAYGLL
VATTSRDSAD TLRLELDGGR VKLMVNLGKG PETLYAGQKL NDNEWHTVRV VRRGKSLKLT
VDDDVAEGTM VGDHTRLEFH NIETGIMTEK RYISVVPSSF IGHLQSLMFN GLLYIDLCKN
GDIDYCELKA RFGLRNIIAD PVTFKTKSSY LSLATLQAYT SMHLFFQFKT TSPDGFILFN
SGDGNDFIAV ELVKGYIHYV FDLGNGPNVI KGNSDRPLND NQWHNVVITR DNSNTHSLKV
DTRVVTQVIN GAKNLDLKGD LYMAGLAQGM YSNLPKLVAS RDGFQGCLAS VDLNGRLPDL
INDALHRSGQ IERGCEGPST TCQEDSCANQ GVCMQQWEGF TCDCSMTSYS GNQCNDPGAT
YIFGKSGGLI LYTWPANDRP STRSDRLAVG FSTTVKDGIL VRIDSAPGLG DFLQLHIEQG
KIGVVFNIGT VDISIKEERT PVNDGKYHVV RFTRNGGNAT LQVDNWPVNE HYPTGNTDNE
RFQMVKQKIP FKYNRPVEEW LQEKGRQLTI FNTQAQIAIG GKDKGRLFQG QLSGLYYDGL
KVLNMAAENN PNIKINGSVR LVGEVPSILG TTQTTSMPPE MSTTVMETTT TMATTTTRKN
RSTASIQPTS DDLVSSAECS SDDEDFVECE PSTGRSGGEL VIPLLVEDPL ATPPIATRAP
SITLPPTFRP LLTIIQTTKD SLSMTSEAGL PCLSDQGSDG CDDDGLVISG YGSGETFDSN
LPPTDDEDFY TTFSLVTDKS LSTSIFEGGY KAHAPKWESK DFRPNKVSET SRTTTTSLSP
ELIRFTASSS SGMVPKLPAG KMNNRDLKPQ PDLVLLPLPT AYELDSTKLK SPLITSPMFR
NVPTANPTEP GIRRVPGASE VIRESSSTTG MVVGIVAAAA LCILILLYAM YKYRNRDEGS
YQVDETRNYI SNSAQSNGTL MKEKQQSSKS GHKKQKNKDR EYYV
//
