ID A0A2R8NCH6_CALJA Unreviewed; 887 AA.
AC A0A2R8NCH6;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Adhesion G protein-coupled receptor F1 {ECO:0000313|Ensembl:ENSCJAP00000064909.2};
GN Name=ADGRF1 {ECO:0000313|Ensembl:ENSCJAP00000064909.2};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000064909.2, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000064909.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000064909.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily.
CC {ECO:0000256|ARBA:ARBA00007343}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A2R8NCH6; -.
DR STRING; 9483.ENSCJAP00000064909; -.
DR Ensembl; ENSCJAT00000085521.3; ENSCJAP00000064909.2; ENSCJAG00000011931.5.
DR GeneTree; ENSGT00940000161228; -.
DR InParanoid; A0A2R8NCH6; -.
DR Proteomes; UP000008225; Chromosome 4.
DR Bgee; ENSCJAG00000011931; Expressed in kidney and 1 other cell type or tissue.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd15932; 7tmB2_GPR116-like_Adhesion_VI; 1.
DR Gene3D; 1.25.40.610; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR008078; GPCR_2_Ig-hepta-like_rcpt.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR000082; SEA_dom.
DR PANTHER; PTHR45813:SF3; ADHESION G-PROTEIN COUPLED RECEPTOR F1; 1.
DR PANTHER; PTHR45813; EF-HAND DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF01390; SEA; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR PRINTS; PR01695; IGHEPTARCPTR.
DR SMART; SM00303; GPS; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50024; SEA; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 547..570
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 582..602
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 622..643
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 655..679
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 703..726
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 752..771
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 777..800
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 107..215
FT /note="SEA"
FT /evidence="ECO:0000259|PROSITE:PS50024"
FT DOMAIN 544..801
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
SQ SEQUENCE 887 AA; 98575 MW; B94E909EB9BD90B3 CRC64;
MVTWASEDYQ SKSYHTLELV SRPVQLQGAR ICNPVYLEES KKYLANSTNK HKDCSSLHGV
LQCTCEDSYT WFPPSCLDPQ NCYLHTAGTF PSCECHNNLS QSVNFCERTK IWGTFKINER
FTNDLLNSSS AVYSKYATGI EIQLKKAYKR IQGFESVQVT QFRNGSIVAG YEVVGSRHAS
ELLSAIEEVA EKAKAALRKL FPLEDSSFRV FRKAQCNDIV FGFGSKDDEY TLPCSSGYRG
NITGRCQSSG WQVIRETCVL PQLEELKKNF SMIVGNATEA AVSSLVRNLS VIIQQSPSST
VGNLALAVSI LGNISSLSLA SHFKVSNSTM EDVINIADHI LSSASVTSWT VLLQEEKHAS
SRLLETLENI SALVPPTALP LNLSRKFINW RGIPVTKSQL KGGYNYQIEM FPPNTSIPVR
GHVLIGSDQF QRSHPETIIS MASLTLGNIL PISKNGNAQV NGPVISTVIQ NYSINEVFLI
FSKIESNLSQ PHCVFWDFSH LQWSDAGCHL VNETPDTVMC RCTHLTSFSM LMSPFVPTTI
LPVVKCITYV GLGISIGSLI LCLIIEALFW KQIKKSQTSH TRHICMVNVA LSLLIADVWF
IVGDTVGTTV NPSGVCTAAV FFTHFFYLSL FFWMLMLGIL LAYRIILVFH HMARPLMMAV
GFCLGYGCPL IISVITIAVT QPRNTYQRKD VCWLNWSRGS KPLLAFVIPA LAIVAVNFLV
VLLVLIKLWR PAVGERLSQD DKTTIVRMGK SLLILTPLLG LTWGFGIGTI VDSQNPAWHV
IFALLNAFQG FFILCFGILL DSKLRQLLFN KLSALSSWKQ TAKSLNERAG PQGPQMTDDE
QQNSSDLSAK LKFSKPFNPL QNKGHYAFTH TGESSNDIML TQFFSTE
//
