ID A0A2R8P6D6_CALJA Unreviewed; 852 AA.
AC A0A2R8P6D6;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=Solute carrier family 26 member 9 {ECO:0000256|RuleBase:RU362052};
DE AltName: Full=Anion transporter/exchanger protein 9 {ECO:0000256|RuleBase:RU362052};
GN Name=SLC26A9 {ECO:0000313|Ensembl:ENSCJAP00000056319.2};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000056319.2, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000056319.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000056319.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- FUNCTION: Ion transporter that can act both as an ion channel and anion
CC exchanger. Mainly acts as a chloride channel, which mediate uncoupled
CC chloride anion transport in an alternate-access mechanism where a
CC saturable binding site is alternately exposed to either one or the
CC other side of the membrane. Also acts as a DIDS- and
CC thiosulfate- sensitive anion exchanger the exchange of chloride for
CC bicarbonate ions across the cell membrane.
CC {ECO:0000256|RuleBase:RU362052}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC {ECO:0000256|ARBA:ARBA00008692, ECO:0000256|RuleBase:RU362052}.
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DR RefSeq; XP_008983809.2; XM_008985561.2.
DR AlphaFoldDB; A0A2R8P6D6; -.
DR STRING; 9483.ENSCJAP00000056319; -.
DR Ensembl; ENSCJAT00000076150.3; ENSCJAP00000056319.2; ENSCJAG00000011074.5.
DR GeneTree; ENSGT01100000263544; -.
DR InParanoid; A0A2R8P6D6; -.
DR OMA; WKDMMGT; -.
DR Proteomes; UP000008225; Chromosome 19.
DR Bgee; ENSCJAG00000011074; Expressed in heart.
DR GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
DR GO; GO:0010008; C:endosome membrane; IEA:Ensembl.
DR GO; GO:0000139; C:Golgi membrane; IEA:Ensembl.
DR GO; GO:0051117; F:ATPase binding; IEA:Ensembl.
DR GO; GO:0005254; F:chloride channel activity; IEA:Ensembl.
DR GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR Gene3D; 3.30.750.24; STAS domain; 1.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR NCBIfam; TIGR00815; sulP; 1.
DR PANTHER; PTHR11814:SF17; SOLUTE CARRIER FAMILY 26 MEMBER 9; 1.
DR PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR Pfam; PF01740; STAS; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SUPFAM; SSF52091; SpoIIaa-like; 1.
DR PROSITE; PS50801; STAS; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362052};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362052}; Transport {ECO:0000256|RuleBase:RU362052}.
FT TRANSMEM 151..178
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 185..204
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 235..260
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 272..292
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 312..330
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 398..417
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 437..458
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 470..488
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 526..556
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT DOMAIN 580..798
FT /note="STAS"
FT /evidence="ECO:0000259|PROSITE:PS50801"
FT REGION 663..714
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 663..699
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 852 AA; 93400 MW; E49B50655C8D1C63 CRC64;
MEKLDRGKGG TLLYGGGEGQ NKTLLLQGPE IEGLGWHRDE ARDVPSTSPP LLLPKPVNAP
DMSQPRPRYV VDRAAYSLTL FDDEFEKKDR TYPVGEKLRN AFRCSSAKIK AVVFGLLPVL
SWLPKYKIKD YIVPDLLGGL SGGSIQVPQG MAFALLANLP AVNGLYSSFF PLLTYFFLGG
VHQMVPGTFA VISILVGNIC LQLAPESKFQ VFNNATNESY VDTAAMEVER LHVSATLACL
TAIIQMGLGF VQFGFVAIYL SESFIRGFMT AAGLQILISV LKYIFGLTVP SYTGPGSIVF
TFIDICKNLP HTNIASLIFA LISGAFLVLV KELNARYMHK IRFPIPTEMI VVVVATAISG
SCKMPKKYHM QIVGEIQRGF PTPVSPVVSQ WKDMIGTAFS LAIVGYVINL AVGRTLASKH
GYNVDSNQEM IALGCSNFFG SFFKIHVICC ALSVTLAVDG AGGKSQVASL CVSLVVMITM
LVLGTYLYPL PKSVLGALIA VNLKNSLKQL TDPYYLWRKS KLDCCIWVVS FLSSFFLSLP
YGVAVGVAFS VLVVIFQTQF RNGYALAQVM DTDIYVNPKT YSRAQDIQGI KIITYCSPLY
FANSEIFRQK VIAKTGMDPQ KVLLAKQKYL KKQEKQRLRP TQQRKSLFMK TKTVSLQELQ
QDFENAPPTD PNNNQTPANG ASVSYITFSP DSSSAARSEP PASAEAPDEP SDTLASVPPF
VTFHTLILDM SGVSFVDLMG IKALAKLSST YGKIGVKVFL VNIHAQVYND ISHGGVFEDG
SLECNHVFPS IHDAVLFAQA NARDVTPRRN FQGAPGDPEL SLYDSEEDIP SYWDLEQEMF
GSMFHTETLT AL
//