ID A0A2R8P951_CALJA Unreviewed; 1269 AA.
AC A0A2R8P951;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Latent transforming growth factor beta binding protein 3 {ECO:0000313|Ensembl:ENSCJAP00000058252.2};
GN Name=LTBP3 {ECO:0000313|Ensembl:ENSCJAP00000058252.2};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000058252.2, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000058252.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000058252.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A2R8P951; -.
DR Ensembl; ENSCJAT00000068764.3; ENSCJAP00000058252.2; ENSCJAG00000002190.5.
DR GeneTree; ENSGT00940000160285; -.
DR Proteomes; UP000008225; Chromosome 11.
DR Bgee; ENSCJAG00000002190; Expressed in ovary and 6 other cell types or tissues.
DR GO; GO:0031012; C:extracellular matrix; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0019838; F:growth factor binding; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 10.
DR Gene3D; 2.10.25.10; Laminin; 15.
DR Gene3D; 3.90.290.10; TGF-beta binding (TB) domain; 3.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR017878; TB_dom.
DR InterPro; IPR036773; TB_dom_sf.
DR PANTHER; PTHR24039; FIBRILLIN-RELATED; 1.
DR PANTHER; PTHR24039:SF28; FIBULIN-1; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF07645; EGF_CA; 10.
DR Pfam; PF12661; hEGF; 2.
DR Pfam; PF00683; TB; 4.
DR SMART; SM00181; EGF; 15.
DR SMART; SM00179; EGF_CA; 14.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF57184; Growth factor receptor domain; 5.
DR SUPFAM; SSF57581; TB module/8-cys domain; 4.
DR PROSITE; PS00010; ASX_HYDROXYL; 9.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 7.
DR PROSITE; PS50026; EGF_3; 11.
DR PROSITE; PS01187; EGF_CA; 5.
DR PROSITE; PS51364; TB; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..40
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 41..1269
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5035175194"
FT DOMAIN 106..138
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 274..317
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 321..361
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 369..421
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 540..581
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 582..619
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 626..668
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 710..750
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 751..791
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 792..831
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 832..874
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 883..937
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1002..1042
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1048..1088
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1102..1152
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT REGION 249..270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 444..516
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1153..1185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 453..467
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 483..503
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1153..1167
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 110..120
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 128..137
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1269 AA; 135672 MW; 16CDEA842580452C CRC64;
MPGPRGAAGG LAPEMRGAGA AGLLALLLLP LLGLGGGAEG GPAGERGAGG GGALARERFK
VVFAPVICKR TCLKGQCRDS CQQGSNMTLI GENGHSTDTL TGSGFRVVVC PLPCMNGGQC
SSRNQCLCPP DFTGRFCQVP AGGAGGSTGG SGPGLGRAGA LSTGALPPLA PEGESVASKH
AIYAVQVIAD PPGPGEGPPA QHAAFLVPLG PGQISAEVQA PPPVVNVRVH HPPEASVQVH
RIEGRNAEGA APSQHLLPHP KPSHPRPPTQ KPLGRCFQDT LPKQPCGSNP LPGLTKQEDC
CGSIGTAWGQ SKCHKCPQLQ YINECAMPGM CRHGDCLNNP GSYRCVCPPG HSLGPSRMQC
IADKPEEKSL CFRLVSPEHQ CQHPLTTRLT RQLCCCSVGK AWGARCQRCP ADGTAAFKEI
CPAGKGYHIL TSHQTLTIQG ESDFSLFLHP DGPPKPQQLP ESPSQAPPPE NTEEERGVTT
DSPVSEERSV QQSHTTATTS PARPYPELIS RPSPPTVRWF LPDLPPSRSA VEIAPTQVTE
TDECRLNQNI CGHGECVPGP PDYSCHCNPG YRSHPQHRYC VDVNECEAEP CGPGRGICMN
TGGSYNCHCN RGYRLHVGAG GRSCVDLNEC AKPHLCGDGG FCINFPGHYK CNCYPGYRLK
ASRPPVCEDI DECRDPSSCP DGKCENKPGS FKCIPCQPGY RSQGGGACRD VNECAEGSPC
SPGWCENLPG SFRCTCAQGY TPAPDGHSCV DVDECEAGDV CDNGICTNTP GSFQCQCLSG
YHLSRDRSHC EDIDECDFPA ACIGGDCINT NGSYRCLCPQ GHRLVGGRKC QDIDECSQDP
GLCLPHGACK NLQGSYVCVC DDGFTPTQDQ HGCEEVEQPH HKKECYLNFD DTVFCDSVLA
TNVTQQECCC SLGAGWGDHC EIYPCPVYSS AEFHSLCPDG KGYTQDNNIV NYGIPAHRDI
DECMLFGAEI CKEGKCVNTQ PGYECYCKQG FYYDGNLLEC VDVDECLDES NCRNGVCENT
RGGYRCACTP PAEYSPAQRQ CLNPEEMDVD ECQDPAACRP GRCVNLPGSY RCECRLPWVP
GPSGRDCQLP ESPAERAPER RDVCWSQRGE DGMCAGPLAG PALTFDDCCC RQGRGWGAQC
RQCPPRGTGS QCPTSQSESN SFWDTSPLLL GKSPRDEDSS EEDSDECRCV SGRCMPRPGG
AVCECPGGFQ LDASRARCVD IDECRELNQR GLLCKSERCV NTSGSFRCVC KAGFARSRPH
GACVPQRRR
//
