ID A0A2R8QCX6_DANRE Unreviewed; 941 AA.
AC A0A2R8QCX6; A0A8M1PSM1;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Netrin receptor UNC5 {ECO:0000256|RuleBase:RU367033};
GN Name=unc5db {ECO:0000313|Ensembl:ENSDARP00000152563,
GN ECO:0000313|RefSeq:XP_001342230.2,
GN ECO:0000313|ZFIN:ZDB-GENE-060531-162};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000152563};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000152563, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000152563};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2] {ECO:0000313|Ensembl:ENSDARP00000152563}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000152563};
RG Ensembl;
RL Submitted (APR-2018) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_001342230.2}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_001342230.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for netrin required for axon guidance. Mediates axon
CC repulsion of neuronal growth cones in the developing nervous system
CC upon ligand binding. {ECO:0000256|RuleBase:RU367033}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU367033}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU367033}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the unc-5 family.
CC {ECO:0000256|ARBA:ARBA00009844, ECO:0000256|RuleBase:RU367033}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BX323062; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR933001; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_001342230.2; XM_001342194.7.
DR STRING; 7955.ENSDARP00000152563; -.
DR Ensembl; ENSDART00000181833; ENSDARP00000152563; ENSDARG00000061541.
DR Ensembl; ENSDART00000181833.1; ENSDARP00000152563.1; ENSDARG00000061541.6.
DR GeneID; 100002445; -.
DR KEGG; dre:100002445; -.
DR AGR; ZFIN:ZDB-GENE-060531-162; -.
DR CTD; 100002445; -.
DR ZFIN; ZDB-GENE-060531-162; unc5db.
DR OMA; TTQLCCT; -.
DR OrthoDB; 2971005at2759; -.
DR Proteomes; UP000000437; Chromosome 5.
DR Bgee; ENSDARG00000061541; Expressed in blastula and 16 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005042; F:netrin receptor activity; IBA:GO_Central.
DR GO; GO:0007411; P:axon guidance; IBA:GO_Central.
DR Gene3D; 2.60.220.30; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 2.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR037936; UNC5.
DR InterPro; IPR033772; UPA.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR12582; NETRIN RECEPTOR UNC5; 1.
DR PANTHER; PTHR12582:SF5; NETRIN RECEPTOR UNC5D; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF00090; TSP_1; 2.
DR Pfam; PF17217; UPA; 1.
DR Pfam; PF00791; ZU5; 1.
DR PRINTS; PR01705; TSP1REPEAT.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00209; TSP1; 2.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 2.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS50092; TSP1; 2.
DR PROSITE; PS51145; ZU5; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU367033};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319,
KW ECO:0000256|RuleBase:RU367033};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367033};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367033};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Signal {ECO:0000256|RuleBase:RU367033};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367033};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367033}.
FT SIGNAL 1..35
FT /evidence="ECO:0000256|RuleBase:RU367033"
FT CHAIN 36..941
FT /note="Netrin receptor UNC5"
FT /evidence="ECO:0000256|RuleBase:RU367033"
FT /id="PRO_5041477866"
FT TRANSMEM 381..404
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367033"
FT DOMAIN 167..249
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 536..677
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 867..922
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
SQ SEQUENCE 941 AA; 104325 MW; E6E3624D93A8FF86 CRC64;
MTERNKTEMG STRKRARRFL EIITVLALCA PHASGRGPVG DALADSLSSV GGTLPHFLQE
PEDAYIIKNN PIKLRCRATP ALQIFFKCNG EWVHQNQHSS QEYMDQNTGV KIREVTINVT
RQQVEDFHGP EDYWCLCVAW SHLGTSKSRR ATVRIAYLRK NFEQDPQGKE VPIKGMIVLH
CRPPEGVPMA KVEWLKNEEL VSALEDDNID TRADHNLIIN EARLSDSANY TCLATNIVAK
RRSTTATVVV FVNGGWSLWT EWSSCSVNCG RGVQKRSRTC TNPAPLNGGA FCEGMSVQKI
ACNAVCPVDG VWEEWSEWTM CSAQCERQRW RECNDPPPRH RGKMCEGEGQ STENCTGGLC
TQNGKLMHDV KPQSMENSMD VALYSGLAAG VIAVVVLIVA ITLYRKSQSE YGVDVIDSSA
LAGGFQSFNF KTTRQGNPLL LNSSMQPDIT VGQTYSSPIC FQDSIDKELF DPLPDKVKVQ
SSFMVSLGVA DRAEYHVKAH PQTLPANLHP NYSMVEGKKT ATMAPNGLHT PGKIQLKTSA
VFGHLGGRLV IPNAGVSLLV PHGAIADDTS WEMYMLINQG ETSAQSEERC EILLGPEITY
GPPGLSLSCP VAMTIAHCAE VSAENWNIKL KRQTKDNKWE EIMSVDDEST SCYCLMDSHS
CHLLLDQPGC YALVGEPITD AAIKRLRIAV FGSMEASSLD YSLRVHCVDD TPHAFQGVVT
AETCRGGQLL EEPKTLFFKG NCLSLQVSIQ DIPQFLWSIK PFTTCQEFSF TQVWYSNQQP
VHCAFSLQRH SAATNQLSCK ISVRQVKGHE QILQVYTSVG ENEKETVPFF MQADCTVTSQ
TGAKAFKIPL SIRQRICTTF DTANAKGKDW QLLAQKLHIQ RNLSYFTKQK SPSAVILSLW
EARHQDSGDL DSLASALEEI GKIHCKSLPQ SPDENETDFT F
//
