ID A0A2R8QCZ8_DANRE Unreviewed; 1478 AA.
AC A0A2R8QCZ8; A0A8M2B6M2;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=ptprua {ECO:0000313|Ensembl:ENSDARP00000150888,
GN ECO:0000313|RefSeq:XP_005159609.1,
GN ECO:0000313|ZFIN:ZDB-GENE-060503-232};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000150888};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000150888, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000150888};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2] {ECO:0000313|Ensembl:ENSDARP00000150888}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000150888};
RG Ensembl;
RL Submitted (APR-2018) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_005159609.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_005159609.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 2B subfamily. {ECO:0000256|ARBA:ARBA00006396}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL929594; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX000467; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR848723; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CU633478; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CU856379; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005159609.1; XM_005159552.4.
DR STRING; 7955.ENSDARP00000150888; -.
DR Ensembl; ENSDART00000189521; ENSDARP00000150888; ENSDARG00000092638.
DR Ensembl; ENSDART00000189521.1; ENSDARP00000150888.1; ENSDARG00000092638.6.
DR GeneID; 563584; -.
DR AGR; ZFIN:ZDB-GENE-060503-232; -.
DR CTD; 563584; -.
DR ZFIN; ZDB-GENE-060503-232; ptprua.
DR OrthoDB; 2875525at2759; -.
DR ChiTaRS; ptprua; zebrafish.
DR Proteomes; UP000000437; Chromosome 19.
DR Bgee; ENSDARG00000092638; Expressed in brain and 12 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IBA:GO_Central.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 2.
DR CDD; cd06263; MAM; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR000998; MAM_dom.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR24051:SF10; PROTEIN-TYROSINE-PHOSPHATASE-RELATED; 1.
DR PANTHER; PTHR24051; SUSHI DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF00629; MAM; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00020; MAMDOMAIN.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00409; IG; 1.
DR SMART; SM00137; MAM; 1.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS00740; MAM_1; 1.
DR PROSITE; PS50060; MAM_2; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Receptor {ECO:0000313|RefSeq:XP_005159609.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..1478
FT /note="protein-tyrosine-phosphatase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041163689"
FT DOMAIN 24..186
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 287..382
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 385..488
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 494..595
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 921..1158
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1078..1149
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1190..1471
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1387..1462
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 654..677
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 845..875
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 845..860
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1478 AA; 166509 MW; AC8004D205094C68 CRC64;
MNLCAVLLFL IARVCAESLE GPTAGCTFEE DSDPTLCEYR QAQEDDFDWQ LVRTYSWPHM
TSDLIRGSYM LVNASQYGAG QRAQLMLRPL SENDTHCVQF SYFLYSRDGH SPGGLNVYVR
VNGGSRGNAV WNVSGSQGRQ WHQVEMAVST FWPSEYQIVF EATISSEQKG YIGLDDIVLL
NYPCYKVPHF SRLGDVEVNA GQNATFQCVA TGRSVKTDPF LMERRNGVLM APYSVTSSIG
ERRLVAWFQV GGAQRGEQDL YRCITQSTFG AAVSNFAELI VRVPPTPIAP PQLLRSGPTY
LIIQLNTNSI VGDGPVIRRE IVYRASHSPW SETHGVNSLT YKVWHLEPDT EYRISVLLTR
PGEGGTGPPG PPLVSRTKCA EPMRPLRGLT ATEIQSRQLL LQWEPVGYNL TRCHTYSLSL
CYRYSTATGG GAGGNNATVR ECLSVERNTS RFTLRDLPPF HTVHVRLALA NPEGKKESRE
VTFQTEEDIP GGIAPESLTF TPLDDMIFLK WEEPLEPNGL ITQYEISYQS IESSDPSINV
PGPRRTVSKL KNETYHMFSG LHPGTTYLVS VRARTAKGFG QTALTEITTN ISAPAFDYED
VPSPLSESES TITVLLRPAL GRGAPVSTYH VVVVEEDGSR QVRRRELGHM ECFPAPSSHG
ETSGGAGGTP PHYYTAELSP SSLPEATPFT VGDNHTYSGY WNTPLDPSKN YLIYFQASSN
FRGETRINCI RIARKVACKD HKRALEVSQH AEDMGLILGA CAGGLVVLIL LLGAIVVIVK
KGRDIYSYPY YPRKKVNINK AVMTYRQEKT CKLGSLDCST TEHSTLQQDD RTAHTFLDSH
NCTARNEQRS TVNESSSLLG GSPRRHCRRK SSPYHTGQLH PAVRVADLLQ HINQMKTGEG
YGFKQEYESF FDGWDINDKK DKTKGRHDTL LGQDRHRVKM HSLLADPNSD YVNANYIDIR
INREGYQRSN HFIATQGPKQ DMIYDFWRMV WQENCYSIVM ITKLVEVGRM KCCKYWPDDS
ELYGDIKITL LKTETLAEYT VRTFAMERRG YPAKHEVCQF HFTSWPEHGV PYHATGLLAF
LRRVKASTPP DAGPVVVHCS MGAGRTGCYI VLDVMLDMAE CEGVVDIYNC VKTLCSRRIN
MIQTEEQYIF IHDAILEACL CGETAIPITE FGLSYKDMLS VDSQTNTSQL REEFQTLNSV
TPHLDVEECS VSLLPRNREK NRSMDVLPPD RALAFLVSNE GDGNNYINAA LMDSFLQPAA
FVVTPHPLPT TTTDFWRLVF DYGCTSIVML NQLNQSNSAW PCLQYWPETG MQQYGPMTVE
LLSRSTDENV VTRLFRVNNI TRDPRENLPC WNADSRIPKK LQEGHLVVRH FQFLRWSAYR
EIPDSKKAFL NLLAQVQKWQ RECGDGRTIV HCLNGGGRSG TFCACTMIME MVHHHNMVDV
FYAVKTLRNS KPNMVESMEQ YRFCYELALE YLDCLEVR
//
