ID A0A2R8QDI1_DANRE Unreviewed; 1201 AA.
AC A0A2R8QDI1; A0A8M2B4R7;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=BCL2-associated athanogene 6 {ECO:0000256|ARBA:ARBA00030033};
GN Name=bag6 {ECO:0000313|Ensembl:ENSDARP00000151719,
GN ECO:0000313|RefSeq:XP_005157822.1,
GN ECO:0000313|ZFIN:ZDB-GENE-010501-5};
GN Synonyms=bat3 {ECO:0000313|RefSeq:XP_005157822.1}, wu:fi30e10
GN {ECO:0000313|RefSeq:XP_005157822.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000151719};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000151719, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000151719,
RC ECO:0000313|Proteomes:UP000000437};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2] {ECO:0000313|Ensembl:ENSDARP00000151719}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000151719};
RG Ensembl;
RL Submitted (APR-2018) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_005157822.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_005157822.1};
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC Secreted, extracellular exosome {ECO:0000256|ARBA:ARBA00004550}.
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DR EMBL; FP102311; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005157822.1; XM_005157765.2.
DR Ensembl; ENSDART00000186605; ENSDARP00000151719; ENSDARG00000075892.
DR Ensembl; ENSDART00000186605.1; ENSDARP00000151719.1; ENSDARG00000075892.3.
DR GeneID; 83910; -.
DR AGR; ZFIN:ZDB-GENE-010501-5; -.
DR CTD; 7917; -.
DR ZFIN; ZDB-GENE-010501-5; bag6.
DR OrthoDB; 3177594at2759; -.
DR Proteomes; UP000000437; Chromosome 15.
DR Bgee; ENSDARG00000075892; Expressed in tail bud paraxial mesoderm and 28 other cell types or tissues.
DR GO; GO:0071818; C:BAT3 complex; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0051787; F:misfolded protein binding; IBA:GO_Central.
DR GO; GO:0031593; F:polyubiquitin modification-dependent protein binding; IBA:GO_Central.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IBA:GO_Central.
DR CDD; cd01809; Ubl_BAG6; 1.
DR InterPro; IPR021925; BAG6.
DR InterPro; IPR048926; Bag6_BAGS.
DR InterPro; IPR000626; Ubiquitin-like_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR15204; LARGE PROLINE-RICH PROTEIN BAG6; 1.
DR PANTHER; PTHR15204:SF0; LARGE PROLINE-RICH PROTEIN BAG6; 1.
DR Pfam; PF12057; BAG6; 1.
DR Pfam; PF20960; Bag6_BAGS; 1.
DR Pfam; PF00240; ubiquitin; 1.
DR SMART; SM00213; UBQ; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50053; UBIQUITIN_2; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 9..70
FT /note="Ubiquitin-like"
FT /evidence="ECO:0000259|PROSITE:PS50053"
FT REGION 81..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 215..277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 396..437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 458..486
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 511..540
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 626..692
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 723..758
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1011..1074
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1178..1201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..242
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 402..437
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 461..481
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 511..526
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 626..677
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 734..748
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1031..1048
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1201 AA; 127271 MW; 1E8C6B2DDE5D9980 CRC64;
MEEQASNTIE VTVKTLDSQS RSYTVEAQMT VKDFKEHISP SVGIPVDKQR LIYQGRVLQD
EKTLTEYNVD GKVIHLVERA PPQTTQQGSG SGGVPGSSGA TQGGNQNPNS TSSTQGTPLG
PTHDRNANSY VMLGTFNLPV NMMDPQQIQM SLQQMMTGLG DNARNPRVST STGTNGSVNV
QIDFDQSLQS EPRLRLLLAE NLLRDTNAVI QRLEGQPADG SSSQEDSAAP PASSTSTPSP
SAQPMDTSPP PSTTPPSSSS STQTEGAPPP AAGLSHPSPA EMVEMLSELR RVEERLQPFI
QRAHLILEAA TTADYNNNTQ ERDEDQRILN LVGEALRLLG NALVALSDLR CNLLSNPPRH
LHVIRPMSHY TSSVLTPAGV HHLPMQLNLG SSVAMSANGR PAAEGQPQTT GQSDQQGQGP
TAANQPGPAN QQSGQTGPRV IRISHQTMEP VVMMQMNIDD SGNAAPPNGQ QNGTGTGQPG
APPTVQIPGL PPEFMQAIVH QVTQQAMAMA NAASTGQQTQ QTPPPAANTG STPPPMPPYP
PQARVVFTRP SFTHRMSSPT FTTRGATINL RAAVPTMMGQ QPGQAGHFPP AALNQMIGGL
VGQLLTGAAG QTASQTATST SQTFTFSTSA STSTPFASTT TTSASGPTQS SSSSTNTSSS
SSSSSSFSTS TSQTGSVPPP PQENPFGGNL EQLLGSLLGG AVAAGGPSPS ITVTMPGVPT
FIQGVTDFMQ PPAGQPPAST PSAPTAPPNT ASAPGATAAA TEGLNPELFT GIVQGVLSTM
MGSLGTPQNE TESIAQFIQR LSQTSNIFTP GTGDAMGFFG DLLALVCQNF SMVDMVLLLH
GQHQPLGRIQ PQLAQFFTEH FLQGREPTEA NITAAADDLI AELEEYITES FSTVAVREGV
DITQTNRAFL RQQLTGIATH ILQCTDQTFG PRLLQLCNRA LFECLALNLY CLNGEQSALT
AVINHRIRTM SAEVNPSLVN WLTSMMTMRL QVILEHIPIT EEQITHYIIN RQSEESVQRP
TPDPEPQNVE MGDTLSPTPA TTAEEALASS QDAGAVGTPA RDGEGAVGGE ETGRDAEAWA
AALPPEWVPI IRQDQVSQRK MKAQPPLSDA YLLGMPAKRR KMVKSDGLRL SLSEAVSQAA
RSAGVTPITS PNALEGDLEN PELQEAYNEQ LKNDIQKRVK DDPDYNPRRF PNTHQVFPPD
S
//