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Database: UniProt
Entry: A0A2R8RU11_DANRE
LinkDB: A0A2R8RU11_DANRE
Original site: A0A2R8RU11_DANRE 
ID   A0A2R8RU11_DANRE        Unreviewed;      2654 AA.
AC   A0A2R8RU11;
DT   20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT   20-JUN-2018, sequence version 1.
DT   10-FEB-2021, entry version 10.
DE   SubName: Full=Centromere protein F {ECO:0000313|Ensembl:ENSDARP00000152810};
GN   Name=cenpf {ECO:0000313|Ensembl:ENSDARP00000152810,
GN   ECO:0000313|ZFIN:ZDB-GENE-041111-205};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000152810, ECO:0000313|Proteomes:UP000000437};
RN   [1] {ECO:0000313|Ensembl:ENSDARP00000152810, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000152810,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000152810}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000152810};
RG   Ensembl;
RL   Submitted (APR-2018) to UniProtKB.
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DR   EMBL; BX936381; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSDART00000189622; ENSDARP00000152810; ENSDARG00000055133.
DR   ZFIN; ZDB-GENE-041111-205; cenpf.
DR   GeneTree; ENSGT00730000111187; -.
DR   Proteomes; UP000000437; Chromosome 17.
DR   ExpressionAtlas; A0A2R8RU11; baseline.
DR   GO; GO:0000775; C:chromosome, centromeric region; IEA:InterPro.
DR   GO; GO:0070840; F:dynein complex binding; IEA:InterPro.
DR   GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:InterPro.
DR   GO; GO:0008134; F:transcription factor binding; IEA:InterPro.
DR   GO; GO:0060271; P:cilium assembly; IMP:ZFIN.
DR   InterPro; IPR043513; Cenp-F.
DR   InterPro; IPR018302; CenpF/LEK1_Rb-prot-bd.
DR   InterPro; IPR019513; Centromere_CenpF_leu-rich_rpt.
DR   InterPro; IPR018463; Centromere_CenpF_N.
DR   PANTHER; PTHR18874; PTHR18874; 2.
DR   Pfam; PF10490; CENP-F_C_Rb_bdg; 1.
DR   Pfam; PF10473; CENP-F_leu_zip; 2.
DR   Pfam; PF10481; CENP-F_N; 1.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A2R8RU11};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT   DOMAIN          1..241
FT                   /note="CENP-F_N"
FT                   /evidence="ECO:0000259|Pfam:PF10481"
FT   DOMAIN          1653..1793
FT                   /note="CENP-F_leu_zip"
FT                   /evidence="ECO:0000259|Pfam:PF10473"
FT   DOMAIN          1891..2029
FT                   /note="CENP-F_leu_zip"
FT                   /evidence="ECO:0000259|Pfam:PF10473"
FT   DOMAIN          2508..2552
FT                   /note="CENP-F_C_Rb_bdg"
FT                   /evidence="ECO:0000259|Pfam:PF10490"
FT   REGION          69..102
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          154..188
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          312..336
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1379..1398
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2381..2519
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2561..2606
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2620..2654
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          107..127
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          214..276
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          482..523
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          531..551
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          555..621
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          654..688
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          738..772
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          787..828
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          864..922
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          961..1016
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1028..1055
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1091..1160
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1182..1223
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1252..1338
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1445..1483
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1552..1572
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1601..1635
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1657..1705
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1734..1824
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1867..2006
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2049..2069
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2077..2108
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2116..2136
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2144..2178
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2218..2245
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        77..102
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        154..174
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        312..332
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2381..2397
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2398..2437
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2438..2453
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2505..2519
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2629..2654
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2654 AA;  304674 MW;  DF8F0AE1C199AF32 CRC64;
     MDSEKSEASA LKRENQSLVE SCEHLEKARQ KLTHDIQTKE QQVNYLEGQL NSFKKQTDRL
     EQEVKKYKHE LERSQTSHAS EIQQLSTPQK TFATPATPNH WQQDSKITDL QEKYNREVEE
     RKKLEAEIKV MHVKLLNQSS VSHKDIARQQ TGSSIFPWQQ DQKSSHQSLP VMETPSRRRN
     GASGMPWSYD DTPIKPHQQF TSGAPSDTVG SQQMEQLKNI NQDLRSKVSE LELRLQAHEK
     DMKNQINKFS EIQSQLEMAK KDVAEKDKLL NKSRDELTKA TGQYEQSVSK CSAFEIKLKQ
     VTEEMNCQRH NAESMHRSLE QKIKDQERES QKELAQLQSS YQALDQQFTQ VKNKTSMEIQ
     QAKKDHNVLQ SEMDKVTALK NRLEKELEEL KQKLLRSEQA LQASQVKEAE TKKKFEEMQR
     EKNTLNCQLD QGMKRVKQLE DEKQNTEQIL AKNRMMVDDL KVKTQTQNEE LTELRKKMDH
     QSVSSAQELE NLKKTLIEAE AKNMKTQAEL QKLVHDVELK ENKICAVEKE NEELKMTSNS
     CQKELAEMKK EYDALLQWKT EKEQLINNAE SNRNELLAKV ADLEKDKDNL SNAHGDLQKK
     MQDLENEKIG LSGQIDSLKG ELLVKCVELE EKGRVYEELQ QQFGETKIKH KKEMDNLNQQ
     ITLTQGKVSE LEAKLLQETS KLEGMEQAHG QLLAEYESAC ILAMSKDSII EMNKTEIVHL
     QESFTLRDQE LEKFKVEKDI LAKECEDRLA QNKELEQQKL NTETSLMEVL AKFTLLESDL
     RCQKDLNAEI QGKYDELSKI KEDLVEKVSS LEKREKDLIN EVESLLQKNK SLCSLEEQFN
     CLVAEAEETR SSLEKVKELQ VQTTTELENQ KTIAENLAID LEEEKKKALS IKQENTQLKV
     KQEEIENKAN DLFEKYESLQ KLHDAVCQEN ANHLKEISIV TEALAEKDAM AERIALIKTE
     LETSNNLSAT LKNSLENLQT QFDSSVELIS SLEKKLHDMS DEKSLLEISI KELTERHNKE
     SEVYVSELET HIKKHKSLEE HISVLETELQ NKSLETKTAS EKLEVTTQEM IKLKQDFSLS
     ENKLSVVTDS NKKVAKELED MKQNVFLQEQ EMEGLRLALS DLKNQEAAKS CEIETLKEKL
     QKAQSEHAKT SETLNEKNIN MSKIKVQLEM LQMDLEDNEN CINAFDAQVE ELQGNVSILE
     AKLSESEAQR SNLESKLESV KEDYVKSSLE VSQLSACLEE SQKEQQSRSV LVAELESLRV
     IHEQLKVSLE QENCKQANLE AMYTNLMDQK LKLESEIQEL KADTQGSQKQ IDQLKQANDR
     LASQIAEQQI HIEQLQSEKN LADTLNKEQT SGGNDQDICE MPFANTSLLP FEEDTAILGM
     SSPKGKHDSQ EEPKTPLSAE EDYKDFALQE QMQNKSSDIE DMSHVLKETV RTMEEQTAIQ
     IEQLKLQHAT ELQSMEEQML NIKNELEAKL KEEKQHTEIL SSQLEATMQQ LQELDIASSS
     LLAADTSQNM GKFASGAQDD LIHHTEQSNS TLGIITESEH SNLETETLKE VLRKREEELL
     HLQSQFEVLE SEMVIRKDLC LDMEGKICKM ESEKTNGTDK LASIIQENEK LNKHIGELKE
     EIDSLTLQLQ TSNCQLTDVM EMMESLEMAK GEWNEKFFQI ESELKRVRSE KANLEKHILS
     MEADIEEMQE QKQKQEAELE TARRTNCSLE QQLNITMAEG GRLKEELILC TDERESETHS
     LMKLKEKADL LEKRETDTKE LIKELEDDIR VGKKQNEVAS DQISVLLKEK EQLIQQSQNL
     ENKIVLLNED NERLLSELND IKHNDSFTSR ETENMSSKIH SLEDENVRLS QSLEMSLLEK
     GEIASRLIST QEEVAQMRQG IEKLKVRIES DERKKNHMSQ LLKAAQRKAD VLQDNIEKLE
     REKELSEQNL EDAILQAETA KAELEEIQAE TQDLTKKIEE MTSELKDLKE EKYKLEQELD
     QKNKLIEELQ LSIQEASVKL KSAEEATLNQ EQMIKDFQFK VGAMEEELRL FQTEVESKEV
     KALELASHLL SLESENKEFA QRVLEYERSQ EELHSSNQSL LKDFESKQQE LSEENTQLRS
     QIAELQALSL IREEQDEELQ KDKVELQSTI AQLEEKTQMQ STKMEVMQNS ISSLEINIQQ
     LEGQLDAMKL MNVELTGKLN SLQESSLHLE TQHKQELCEA KEIQNALEIN QNLLTCQLQE
     SQKQIEEYKF SLEALAAEKD GLQKSISVIQ ESHDVQLKEN NMRHEENLKR TQQQLEVELN
     ALKENILVAE KNAAQYQSDL ESIKSQNAEK DSALKELQNK WENCQKEKAE LDSKITRLSK
     EKDSAMSKIN LWMKSCKQLE NEKQTLQEEL QQQGQEIETL KASKEQAEGS SSSGALQEEL
     EELKEALEEK SREADDSMDR YCSLMVKVHK LEDSNESLKN QLKQLSTQTK TPKSRRSLRS
     ETSDLENSNP EGVTSGKRQR AIDDTPNKAQ EALHNITKRL KAAAATPKAK QDDEDFRPEG
     LPELVQKGFA DIPVGEMSPF IVRRTTAQRC SPRLAARTTA VLQSSGSAEH PAQISMQTAE
     GRTPNTVQKP KATPSRNVPL LSTLTNSPLK NSCERLAPVI EQKISRRSRS FKNSPQTSEQ
     VTASPKQNDN CQVQ
//
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