ID A0A2R8RU11_DANRE Unreviewed; 2654 AA.
AC A0A2R8RU11;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 10-FEB-2021, entry version 10.
DE SubName: Full=Centromere protein F {ECO:0000313|Ensembl:ENSDARP00000152810};
GN Name=cenpf {ECO:0000313|Ensembl:ENSDARP00000152810,
GN ECO:0000313|ZFIN:ZDB-GENE-041111-205};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000152810, ECO:0000313|Proteomes:UP000000437};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000152810, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000152810,
RC ECO:0000313|Proteomes:UP000000437};
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2] {ECO:0000313|Ensembl:ENSDARP00000152810}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000152810};
RG Ensembl;
RL Submitted (APR-2018) to UniProtKB.
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DR EMBL; BX936381; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSDART00000189622; ENSDARP00000152810; ENSDARG00000055133.
DR ZFIN; ZDB-GENE-041111-205; cenpf.
DR GeneTree; ENSGT00730000111187; -.
DR Proteomes; UP000000437; Chromosome 17.
DR ExpressionAtlas; A0A2R8RU11; baseline.
DR GO; GO:0000775; C:chromosome, centromeric region; IEA:InterPro.
DR GO; GO:0070840; F:dynein complex binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:InterPro.
DR GO; GO:0008134; F:transcription factor binding; IEA:InterPro.
DR GO; GO:0060271; P:cilium assembly; IMP:ZFIN.
DR InterPro; IPR043513; Cenp-F.
DR InterPro; IPR018302; CenpF/LEK1_Rb-prot-bd.
DR InterPro; IPR019513; Centromere_CenpF_leu-rich_rpt.
DR InterPro; IPR018463; Centromere_CenpF_N.
DR PANTHER; PTHR18874; PTHR18874; 2.
DR Pfam; PF10490; CENP-F_C_Rb_bdg; 1.
DR Pfam; PF10473; CENP-F_leu_zip; 2.
DR Pfam; PF10481; CENP-F_N; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Proteomics identification {ECO:0000213|PeptideAtlas:A0A2R8RU11};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT DOMAIN 1..241
FT /note="CENP-F_N"
FT /evidence="ECO:0000259|Pfam:PF10481"
FT DOMAIN 1653..1793
FT /note="CENP-F_leu_zip"
FT /evidence="ECO:0000259|Pfam:PF10473"
FT DOMAIN 1891..2029
FT /note="CENP-F_leu_zip"
FT /evidence="ECO:0000259|Pfam:PF10473"
FT DOMAIN 2508..2552
FT /note="CENP-F_C_Rb_bdg"
FT /evidence="ECO:0000259|Pfam:PF10490"
FT REGION 69..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 154..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 312..336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1379..1398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2381..2519
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2561..2606
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2620..2654
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 107..127
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 214..276
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 482..523
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 531..551
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 555..621
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 654..688
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 738..772
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 787..828
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 864..922
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 961..1016
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1028..1055
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1091..1160
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1182..1223
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1252..1338
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1445..1483
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1552..1572
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1601..1635
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1657..1705
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1734..1824
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1867..2006
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2049..2069
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2077..2108
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2116..2136
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2144..2178
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2218..2245
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 77..102
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 154..174
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 312..332
FT /note="Polyampholyte"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2381..2397
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2398..2437
FT /note="Polyampholyte"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2438..2453
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2505..2519
FT /note="Polyampholyte"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2629..2654
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2654 AA; 304674 MW; DF8F0AE1C199AF32 CRC64;
MDSEKSEASA LKRENQSLVE SCEHLEKARQ KLTHDIQTKE QQVNYLEGQL NSFKKQTDRL
EQEVKKYKHE LERSQTSHAS EIQQLSTPQK TFATPATPNH WQQDSKITDL QEKYNREVEE
RKKLEAEIKV MHVKLLNQSS VSHKDIARQQ TGSSIFPWQQ DQKSSHQSLP VMETPSRRRN
GASGMPWSYD DTPIKPHQQF TSGAPSDTVG SQQMEQLKNI NQDLRSKVSE LELRLQAHEK
DMKNQINKFS EIQSQLEMAK KDVAEKDKLL NKSRDELTKA TGQYEQSVSK CSAFEIKLKQ
VTEEMNCQRH NAESMHRSLE QKIKDQERES QKELAQLQSS YQALDQQFTQ VKNKTSMEIQ
QAKKDHNVLQ SEMDKVTALK NRLEKELEEL KQKLLRSEQA LQASQVKEAE TKKKFEEMQR
EKNTLNCQLD QGMKRVKQLE DEKQNTEQIL AKNRMMVDDL KVKTQTQNEE LTELRKKMDH
QSVSSAQELE NLKKTLIEAE AKNMKTQAEL QKLVHDVELK ENKICAVEKE NEELKMTSNS
CQKELAEMKK EYDALLQWKT EKEQLINNAE SNRNELLAKV ADLEKDKDNL SNAHGDLQKK
MQDLENEKIG LSGQIDSLKG ELLVKCVELE EKGRVYEELQ QQFGETKIKH KKEMDNLNQQ
ITLTQGKVSE LEAKLLQETS KLEGMEQAHG QLLAEYESAC ILAMSKDSII EMNKTEIVHL
QESFTLRDQE LEKFKVEKDI LAKECEDRLA QNKELEQQKL NTETSLMEVL AKFTLLESDL
RCQKDLNAEI QGKYDELSKI KEDLVEKVSS LEKREKDLIN EVESLLQKNK SLCSLEEQFN
CLVAEAEETR SSLEKVKELQ VQTTTELENQ KTIAENLAID LEEEKKKALS IKQENTQLKV
KQEEIENKAN DLFEKYESLQ KLHDAVCQEN ANHLKEISIV TEALAEKDAM AERIALIKTE
LETSNNLSAT LKNSLENLQT QFDSSVELIS SLEKKLHDMS DEKSLLEISI KELTERHNKE
SEVYVSELET HIKKHKSLEE HISVLETELQ NKSLETKTAS EKLEVTTQEM IKLKQDFSLS
ENKLSVVTDS NKKVAKELED MKQNVFLQEQ EMEGLRLALS DLKNQEAAKS CEIETLKEKL
QKAQSEHAKT SETLNEKNIN MSKIKVQLEM LQMDLEDNEN CINAFDAQVE ELQGNVSILE
AKLSESEAQR SNLESKLESV KEDYVKSSLE VSQLSACLEE SQKEQQSRSV LVAELESLRV
IHEQLKVSLE QENCKQANLE AMYTNLMDQK LKLESEIQEL KADTQGSQKQ IDQLKQANDR
LASQIAEQQI HIEQLQSEKN LADTLNKEQT SGGNDQDICE MPFANTSLLP FEEDTAILGM
SSPKGKHDSQ EEPKTPLSAE EDYKDFALQE QMQNKSSDIE DMSHVLKETV RTMEEQTAIQ
IEQLKLQHAT ELQSMEEQML NIKNELEAKL KEEKQHTEIL SSQLEATMQQ LQELDIASSS
LLAADTSQNM GKFASGAQDD LIHHTEQSNS TLGIITESEH SNLETETLKE VLRKREEELL
HLQSQFEVLE SEMVIRKDLC LDMEGKICKM ESEKTNGTDK LASIIQENEK LNKHIGELKE
EIDSLTLQLQ TSNCQLTDVM EMMESLEMAK GEWNEKFFQI ESELKRVRSE KANLEKHILS
MEADIEEMQE QKQKQEAELE TARRTNCSLE QQLNITMAEG GRLKEELILC TDERESETHS
LMKLKEKADL LEKRETDTKE LIKELEDDIR VGKKQNEVAS DQISVLLKEK EQLIQQSQNL
ENKIVLLNED NERLLSELND IKHNDSFTSR ETENMSSKIH SLEDENVRLS QSLEMSLLEK
GEIASRLIST QEEVAQMRQG IEKLKVRIES DERKKNHMSQ LLKAAQRKAD VLQDNIEKLE
REKELSEQNL EDAILQAETA KAELEEIQAE TQDLTKKIEE MTSELKDLKE EKYKLEQELD
QKNKLIEELQ LSIQEASVKL KSAEEATLNQ EQMIKDFQFK VGAMEEELRL FQTEVESKEV
KALELASHLL SLESENKEFA QRVLEYERSQ EELHSSNQSL LKDFESKQQE LSEENTQLRS
QIAELQALSL IREEQDEELQ KDKVELQSTI AQLEEKTQMQ STKMEVMQNS ISSLEINIQQ
LEGQLDAMKL MNVELTGKLN SLQESSLHLE TQHKQELCEA KEIQNALEIN QNLLTCQLQE
SQKQIEEYKF SLEALAAEKD GLQKSISVIQ ESHDVQLKEN NMRHEENLKR TQQQLEVELN
ALKENILVAE KNAAQYQSDL ESIKSQNAEK DSALKELQNK WENCQKEKAE LDSKITRLSK
EKDSAMSKIN LWMKSCKQLE NEKQTLQEEL QQQGQEIETL KASKEQAEGS SSSGALQEEL
EELKEALEEK SREADDSMDR YCSLMVKVHK LEDSNESLKN QLKQLSTQTK TPKSRRSLRS
ETSDLENSNP EGVTSGKRQR AIDDTPNKAQ EALHNITKRL KAAAATPKAK QDDEDFRPEG
LPELVQKGFA DIPVGEMSPF IVRRTTAQRC SPRLAARTTA VLQSSGSAEH PAQISMQTAE
GRTPNTVQKP KATPSRNVPL LSTLTNSPLK NSCERLAPVI EQKISRRSRS FKNSPQTSEQ
VTASPKQNDN CQVQ
//
