ID A0A2R8Y4H6_HUMAN Unreviewed; 152 AA.
AC A0A2R8Y4H6;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Radixin {ECO:0000313|Ensembl:ENSP00000494060.1};
DE Flags: Fragment;
GN Name=RDX {ECO:0000313|Ensembl:ENSP00000494060.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000494060.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000494060.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [2] {ECO:0007829|PubMed:21269460}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [3] {ECO:0007829|PubMed:24275569}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [4] {ECO:0000313|Ensembl:ENSP00000494060.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AP001889; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AP001981; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF455503; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF510350; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF511111; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF511113; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR MassIVE; A0A2R8Y4H6; -.
DR PeptideAtlas; A0A2R8Y4H6; -.
DR Antibodypedia; 633; 508 antibodies from 39 providers.
DR Ensembl; ENST00000645312.1; ENSP00000494060.1; ENSG00000137710.17.
DR HGNC; HGNC:9944; RDX.
DR VEuPathDB; HostDB:ENSG00000137710; -.
DR GeneTree; ENSGT01090000260082; -.
DR ChiTaRS; RDX; human.
DR Proteomes; UP000005640; Chromosome 11.
DR Bgee; ENSG00000137710; Expressed in adrenal tissue and 214 other cell types or tissues.
DR ExpressionAtlas; A0A2R8Y4H6; baseline and differential.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR Gene3D; 6.10.360.10; -; 1.
DR InterPro; IPR011174; ERM.
DR InterPro; IPR011259; ERM_C_dom.
DR InterPro; IPR000798; Ez/rad/moesin-like.
DR InterPro; IPR008954; Moesin_tail_sf.
DR PANTHER; PTHR23281; MERLIN/MOESIN/EZRIN/RADIXIN; 1.
DR PANTHER; PTHR23281:SF14; RADIXIN; 1.
DR Pfam; PF00769; ERM_C; 1.
DR PRINTS; PR00661; ERMFAMILY.
DR SUPFAM; SSF48678; Moesin tail domain; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:A0A2R8Y4H6,
KW ECO:0007829|MaxQB:A0A2R8Y4H6};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 56..131
FT /note="Ezrin/radixin/moesin C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00769"
FT REGION 1..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..29
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..44
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 53..72
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSP00000494060.1"
SQ SEQUENCE 152 AA; 17448 MW; 5FD1A1F6F5F659D8 CRC64;
XEDLEKTKEE LKTVMSAPPP PPPPPVIPPT ENEHDEHDEN NAEASAELSN EGVMNHRSEE
ERVTETQKNE RVKKQLQALS SELAQARDET KKTQNDVLHA ENVKAGRDKY KTLRQIRQGN
TKQRIDEFEA MWGPKLYALF QMRSCQSSIK QM
//
