ID A0A2R8Z735_PANPA Unreviewed; 1120 AA.
AC A0A2R8Z735;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=DENN domain containing 5B {ECO:0000313|Ensembl:ENSPPAP00000000628.1};
GN Name=DENND5B {ECO:0000313|Ensembl:ENSPPAP00000000628.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000000628.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000000628.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000000628.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RAB6IP1 family.
CC {ECO:0000256|ARBA:ARBA00006664}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
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DR EMBL; AJFE02043909; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02043910; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02043911; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02043912; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02043913; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02043914; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02043915; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02043916; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02043917; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02043918; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2R8Z735; -.
DR Ensembl; ENSPPAT00000002770.1; ENSPPAP00000000628.1; ENSPPAG00000002190.1.
DR GeneTree; ENSGT00940000153678; -.
DR Proteomes; UP000240080; Chromosome 12.
DR Bgee; ENSPPAG00000002190; Expressed in testis and 6 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR CDD; cd01757; PLAT_RAB6IP1; 1.
DR CDD; cd17691; RUN1_DENND5B; 1.
DR CDD; cd17693; RUN2_DENND5B; 1.
DR Gene3D; 1.20.58.900; -; 3.
DR Gene3D; 3.40.50.11500; -; 1.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR047278; DEN5A/B.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR047277; PLAT_RAB6IP1.
DR InterPro; IPR047293; RUN1_DENND5B.
DR InterPro; IPR047292; RUN2_DENND5B.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR InterPro; IPR037516; Tripartite_DENN.
DR PANTHER; PTHR46070:SF3; DENN DOMAIN-CONTAINING PROTEIN 5B; 1.
DR PANTHER; PTHR46070; PINSTRIPE, ISOFORM A; 1.
DR Pfam; PF03455; dDENN; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF01477; PLAT; 1.
DR Pfam; PF02759; RUN; 2.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00593; RUN; 2.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR SUPFAM; SSF140741; RUN domain-like; 2.
DR PROSITE; PS50211; DENN; 1.
DR PROSITE; PS50095; PLAT; 1.
DR PROSITE; PS50826; RUN; 2.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..427
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT DOMAIN 618..778
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT DOMAIN 782..890
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT DOMAIN 964..1113
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
SQ SEQUENCE 1120 AA; 127921 MW; 302FDCBFEB52EB52 CRC64;
MDSLASSLDE GDTTSLLKLQ RYNSYDISRD TLYVSKSICL ITPLPFMQAC KKFLIQLYKA
VTSQQPPPLP LESYIHNILY EVPLPPPGRS LKFYGVYEPV ICQRPGPSEL PLSDYPLREA
FELLGLENLV QVFTCVLLEM QILLYSQDYQ RLMTVAEGIT TLLFPFQWQH VYVPILPASL
LHFLDAPVPY LMGLQSKEGT DRSKLELPQE ANLCFVDVDN HFIELPEEFP QFPNKVDFIQ
ELSEVLVQFG IPPEGSVHCS ESTSKLKNMV LKDLVNDKKN GNVCTNNISM YELLKGNETI
ARLQALAKRT GVAVEKMDLS ASLGEKDKDL KLHCEEAELR DYQLNVQLRE VFANRFTQMF
ADYEAFVIQT AQDMESWLTN REQMQNFDKA SFLSDQPEPY LPFLSRFIET QMFATFIDNK
IMSQWEEKDP LLRVFDTRID KIRLYNVRAP TLRTSIYQKC STLKEAAQSI EQRLMKMDHT
AIHPHLLDMK IGQGKYEQGF FPKLQSDVLA TGPTSNNRWV SRSATAQRRK ERLRQHSEHV
GLDNDLREKY MQEARSLGKN LRQPKLSDLS PAVIAQTNCK FVEGLLKECR MKTKRMLVEK
MGHEAVELGH GEANITGLEE NTLIASLCDL LERIWSHGLQ VKQGKSALWS HLIQFQDREE
KQEHLAESPV ALGPERRKSD SGVMLPTLRV SLIQDMRHIQ NMSEIKTDVG RARAWIRLSL
EKKLLSQHLK QLLSNQPLTK KLYKRYAFLR CEEEREQFLY HLLSLNAVDY FCFTSVFTTI
MIPYRSVIIP IKKLSNAIIT SNPWICVSGE LGDTGVMQIP KNLLEMTFEC QNLGKLTTVQ
IGHDNSGLLA KWLVDCVMVR NEITGHTYRF PCGRWLGKGI DDGSLERILI GELMTSASDE
DLVKQCRTPP QQKSPTTARR LSITSLTGKN NKPNAGQIQE GIGEAVNNIV KHFHKPEKER
GSLTVLLCGE NGLVAALEQV FHHGFKSARI FHKNVFIWDF IEKVVAYFET TDQILDNEDD
VLIQKSSCKT FCHYVNAINT APRNIGKDGK FQILVCLGTR DRLLPQWIPL LAECPAITRM
YEESALLRDR MTVNSLIRIL QTIQDFTIVL EGSLIKGVDV
//
