ID A0A2R8Z7T5_PANPA Unreviewed; 544 AA.
AC A0A2R8Z7T5;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Zinc finger protein 891 {ECO:0000313|Ensembl:ENSPPAP00000000938.1};
GN Name=ZNF891 {ECO:0000313|Ensembl:ENSPPAP00000000938.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000000938.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000000938.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000000938.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC {ECO:0000256|ARBA:ARBA00003767}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000256|ARBA:ARBA00006991}.
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DR EMBL; AJFE02047600; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_008965583.1; XM_008967335.1.
DR RefSeq; XP_008965585.1; XM_008967337.2.
DR RefSeq; XP_008965586.1; XM_008967338.2.
DR AlphaFoldDB; A0A2R8Z7T5; -.
DR Ensembl; ENSPPAT00000004287.1; ENSPPAP00000000938.1; ENSPPAG00000003965.1.
DR GeneID; 103785410; -.
DR KEGG; pps:103785410; -.
DR CTD; 101060200; -.
DR GeneTree; ENSGT00940000164587; -.
DR OMA; QHKIPEG; -.
DR OrthoDB; 458400at2759; -.
DR Proteomes; UP000240080; Chromosome 12.
DR Bgee; ENSPPAG00000003965; Expressed in cerebellum and 5 other cell types or tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 6.10.140.140; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 8.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR23226:SF317; RCG31665-RELATED; 1.
DR PANTHER; PTHR23226; ZINC FINGER AND SCAN DOMAIN-CONTAINING; 1.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 3.
DR Pfam; PF13465; zf-H2C2_2; 3.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 8.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 4.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 8.
PE 3: Inferred from homology;
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 43..113
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 320..347
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 348..375
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 376..403
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 404..431
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 432..459
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 460..487
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 488..515
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 516..543
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
SQ SEQUENCE 544 AA; 63659 MW; AA3B003B03B287AE CRC64;
MAVMDLSSPW ALTKQDSACF HLRNAEEERM IAVFLTTWLQ EPMTFKDVAV EFTQEEWMML
DSAQRSLYRD VMLENYRNLT SVEYQLYRLT VISPLDQEEI RNMKKRIPQA ICPDQKIQPK
TKESTVQKIL WEEPSNAVKM IKLTMHNWSS TLREDWECHK IRKQHKIPGG HWRQMTYAPK
KTVSQELFRD YHELEENSKL RSKLIFPQSI FTSKHCQKCY SEIGCLKHNS IINNYVKNSI
SEKLYESHEC DTTLWHLQRN QTVQKEYTYS KHGMHFTHNM FPVPNNLHMA QNACECNKDE
TLCHQSSLKK QGQTHTEKKH ECNQCGKAFK RISNLTLYKK SHMGEKQYEC KECGKVFNDS
STLRRHVRTH TGEKPYECNQ CGKAFSQKTS LKAHMRTHTG EKPYECNQCG KSFGTSSYLI
VHKRIHTGEK LYECSECGKA FNTSSHLKVH KKIHTGENLY ECSDCGKVFS GVSSLRMHIR
THTGEKPYEC KECRKAFSVS SSLRRHVRIH TGEKPYECIQ CGKAFSQSSS LIIHKRIHTE
RETL
//
